T Cell Receptor and Coreceptor CD8αα Bind Peptide-MHC Independently and with Distinct Kinetics

Phenotypic Analysis of Antigen-Specific T Lymphocytes

1996 • 3,611 citations

Kinetic proofreading in T-cell receptor signal transduction.

1995 • 931 citations

LIGAND RECOGNITION BY αβ T CELL RECEPTORS

1998 • 904 citations

HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides.

1992 • 684 citations

USE OF SURFACE PLASMON RESONANCE TO PROBE THE EQUILIBRIUM AND DYNAMIC ASPECTS OF INTERACTIONS BETWEEN BIOLOGICAL MACROMOLECULES

1997 • 620 citations

T-cell-receptor affinity and thymocyte positive selection

1996 • 620 citations

The T Cell Receptor as a Multicomponent Signalling Machine: CD4/CD8 Coreceptors and CD45 in T Cell Activation

1992 • 539 citations

CD80 (B7-1) Binds Both CD28 and CTLA-4 with a Low Affinity and Very Fast Kinetics

1997 • 525 citations

Crystal structure of the complex between human CD8αα and HLA-A2

1997 • 471 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

A TCR Binds to Antagonist Ligands with Lower Affinities and Faster Dissociation Rates Than to Agonists

1996 • 430 citations

The structure and ligand interactions of CD2: implications for T-cell function

1996 • 397 citations

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes

1996 • 326 citations

Kinetic discrimination in T-cell activation.

1996 • 286 citations

Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide.

1991 • 286 citations

Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment.

1995 • 268 citations

A kinase-independent function of Lck in potentiating antigen-specific T cell activation

1993 • 252 citations

Molecular associations between the T-lymphocyte antigen receptor complex and the surface antigens CD2, CD4, or CD8 and CD5.

1992 • 226 citations

Transient intercellular adhesion: the importance of weak protein-protein interactions

1994 • 213 citations

Human Cell-Adhesion Molecule CD2 Binds CD58 (LFA-3) with a Very Low Affinity and an Extremely Fast Dissociation Rate but Does Not Bind CD48 or CD59

1994 • 204 citations

Affinity and Kinetic Analysis of L-selectin (CD62L) Binding to Glycosylation-dependent Cell-adhesion Molecule-1

1998 • 197 citations

Direct evidence for two affinity states for lymphocyte function-associated antigen 1 on activated T cells.

1993 • 195 citations

Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8αα Ectodomain Fragment in Complex with H-2Kb

1998 • 185 citations

Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 • 176 citations

CD2 and the nature of protein interactions mediating cell‐cell recognition

1998 • 153 citations

Activated CD8 binding to class I protein mediated by the T-cell receptor results in signalling

1990 • 136 citations

Helper T-cell development in the absence of CD4-p56 Ick association

1993 • 132 citations

BirA Enzyme: Production and Application in the Study of Membrane Receptor–Ligand Interactions by Site-Specific Biotinylation

1999 • 119 citations

CD4 and CD8: modulators of T-cell receptor recognition of antigen and of immune responses?

1998 • 117 citations

Affinity and kinetic analysis of the interaction of the cell adhesion molecules rat CD2 and CD48.

1993 • 115 citations

CD4 Augments the Response of a T Cell to Agonist but Not to Antagonist Ligands

1997 • 114 citations

The CD8 coreceptor revisited: One chain good, two chains better

1994 • 99 citations

Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events

1992 • 94 citations

The p56^lck SH2 domain mediates recruitment of CD8/p56^lck to the activated T cell receptor/CD3/ζ complex

1996 • 62 citations

The role of charge and multiple faces of the CD8alpha/alpha homodimer in binding to major histocompatibility complex class Imolecules: support for a bivalent model.

1994 • 51 citations

Assembly and crystallization of the complex between the human T cell coreceptor CD8α homodimer and HLA‐A2

1998 • 25 citations

Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide

1997 • 7 citations