NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders

Glutamate receptor ion channels

2005 • 3,667 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

Pathways towards and away from Alzheimer's disease

2004 • 2,936 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

AMPA Receptor Trafficking and Synaptic Plasticity

2002 • 2,540 citations

NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory

2006 • 2,533 citations

Homeostatic plasticity in the developing nervous system

2004 • 2,371 citations

Critical period plasticity in local cortical circuits

2005 • 2,144 citations

Genetic enhancement of learning and memory in mice

1999 • 1,831 citations

Neuregulin 1 and Susceptibility to Schizophrenia

2002 • 1,654 citations

Metaplasticity: the plasticity of synaptic plasticity

1996 • 1,638 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

PDZ domain proteins of synapses

2004 • 1,525 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1994 • 1,342 citations

PSD-95 Involvement in Maturation of Excitatory Synapses

2000 • 1,238 citations

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

2003 • 1,133 citations

A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.

1989 • 1,114 citations

Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

2004 • 1,084 citations

Mice with Reduced NMDA Receptor Expression Display Behaviors Related to Schizophrenia

1999 • 1,063 citations

Receptor trafficking and synaptic plasticity

2004 • 995 citations

AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

2006 • 982 citations

Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome system

2003 • 972 citations

Activation of Synaptic NMDA Receptors Induces Membrane Insertion of New AMPA Receptors and LTP in Cultured Hippocampal Neurons

2001 • 898 citations

Specific Coupling of NMDA Receptor Activation to Nitric Oxide Neurotoxicity by PSD-95 Protein

1999 • 821 citations

Molecular motors and mechanisms of directional transport in neurons

2005 • 815 citations

The Incorporation of NMDA Receptors with a Distinct Subunit Composition at Nascent Hippocampal SynapsesIn Vitro

1999 • 780 citations

Role of Distinct NMDA Receptor Subtypes at Central Synapses

2004 • 766 citations

Activity-Dependent Decrease in NMDA Receptor Responses During Development of the Visual Cortex

1992 • 731 citations

Developmental changes in distribution of NMDA receptor channel subunit mRNAs

1992 • 718 citations

Orexin A in the VTA Is Critical for the Induction of Synaptic Plasticity and Behavioral Sensitization to Cocaine

2006 • 704 citations

Kinesin Superfamily Motor Protein KIF17 and mLin-10 in NMDA Receptor-Containing Vesicle Transport

2000 • 700 citations

Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation

1998 • 693 citations

NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII

2005 • 685 citations

Differential Roles of NR2A and NR2B-Containing NMDA Receptors in Cortical Long-Term Potentiation and Long-Term Depression

2004 • 678 citations

Regulatory mechanisms of AMPA receptors in synaptic plasticity

2007 • 677 citations

NR2A Subunit Expression Shortens NMDA Receptor Synaptic Currents in Developing Neocortex

1997 • 612 citations

Schizophrenia: Diverse Approaches to a Complex Disease

2002 • 604 citations

Rapid, experience-dependent expression of synaptic NMDA receptors in visual cortex in vivo

1999 • 579 citations

Altered neuregulin 1–erbB4 signaling contributes to NMDA> receptor hypofunction in schizophrenia

2006 • 559 citations

Internalization of ionotropic glutamate receptors in response to mGluR activation

2001 • 540 citations

Molecular determinants of NMDA receptor internalization

2001 • 529 citations

Subunit-Specific NMDA Receptor Trafficking to Synapses

2002 • 503 citations

Ca2+-permeable AMPA receptors in synaptic plasticity and neuronal death

2007 • 496 citations

Activity Regulates the Synaptic Localization of the NMDA Receptor in Hippocampal Neurons

1997 • 493 citations

Assembly of New Individual Excitatory Synapses

2000 • 490 citations

Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia

2003 • 480 citations

Alternatively spliced isoforms of the NMDARI receptor subunit

1995 • 450 citations

Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro

1993 • 447 citations

Role of ampa receptor endocytosis in synaptic plasticity

2001 • 436 citations

Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience

1995 • 428 citations

Neuroanatomy (Text and Atlas)

1990 • 419 citations

Protein kinase C modulates NMDA receptor trafficking and gating

2001 • 418 citations

An NMDA Receptor ER Retention Signal Regulated by Phosphorylation and Alternative Splicing

2001 • 414 citations

Mobile NMDA Receptors at Hippocampal Synapses

2002 • 413 citations

Visual Experience and Deprivation Bidirectionally Modify the Composition and Function of NMDA Receptors in Visual Cortex

2001 • 411 citations

Glycine binding primes NMDA receptor internalization

2003 • 408 citations

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors

2004 • 403 citations

Regulation of morphological postsynaptic silent synapses in developing hippocampal neurons

1999 • 399 citations

The role of receptor diffusion in the organization of the postsynaptic membrane

2003 • 398 citations

Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins

2006 • 378 citations

Bidirectional, experience-dependent regulation of N- methyl- <scp>d</scp> -aspartate receptor subunit composition in the rat visual cortex during postnatal development

1999 • 377 citations

G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors

1999 • 371 citations

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

1991 • 370 citations

Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane

2001 • 368 citations

The Synaptic Localization of NR2B-Containing NMDA Receptors Is Controlled by Interactions with PDZ Proteins and AP-2

2005 • 364 citations

LTP leads to rapid surface expression of NMDA but not AMPA receptors in adult rat CA1

2001 • 353 citations

Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines

2002 • 346 citations

Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses

2000 • 344 citations

PDZ Domain Suppression of an ER Retention Signal in NMDA Receptor NR1 Splice Variants

2000 • 344 citations

NMDA receptor surface mobility depends on NR2A-2B subunits

2006 • 343 citations

NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex

2003 • 323 citations

Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons

2005 • 303 citations

Lack of NMDA Receptor Subtype Selectivity for Hippocampal Long-Term Potentiation

2005 • 301 citations

Decoding NMDA Receptor Signaling: Identification of Genomic Programs Specifying Neuronal Survival and Death

2007 • 301 citations

Experience Strengthening Transmission by Driving AMPA Receptors into Synapses

2003 • 300 citations

Insulin promotes rapid delivery of N -methyl- <scp>d</scp> - aspartate receptors to the cell surface by exocytosis

2001 • 300 citations

Neuroanatomy: Text and Atlas

1989 • 295 citations

Rapid recruitment of NMDA receptor transport packets to nascent synapses

2002 • 283 citations

Calmodulin Mediates Calcium-Dependent Inactivation of N-Methyl-D-Aspartate Receptors

1998 • 280 citations

NMDA-receptor trafficking and targeting: implications for synaptic transmission and plasticity

2002 • 280 citations

Interactions of calmodulin and alpha-actinin with the NR1 subunit modulate Ca2+-dependent inactivation of NMDA receptors.

1999 • 279 citations

Synaptic and Extrasynaptic NMDA Receptor NR2 Subunits in Cultured Hippocampal Neurons

2005 • 274 citations

Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC , encoding the calcineurin gamma subunit

2003 • 248 citations

A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux

2001 • 245 citations

Activity-Dependent mRNA Splicing Controls ER Export and Synaptic Delivery of NMDA Receptors

2003 • 240 citations

Subunit-Specific Regulation of NMDA Receptor Endocytosis

2004 • 239 citations

Ontogeny of postsynaptic density proteins at glutamatergic synapses

2005 • 235 citations

Presynaptic ionotropic receptors and control of transmitter release

2004 • 231 citations

Learning Mechanisms in Addiction: Synaptic Plasticity in the Ventral Tegmental Area as a Result of Exposure to Drugs of Abuse

2004 • 230 citations

Selective Abolition of the NMDA Component of Long-Term Potentiation in Mice Lacking mGluR5

1998 • 229 citations

Interactions of Calmodulin and α-Actinin with the NR1 Subunit Modulate Ca²⁺-Dependent Inactivation of NMDA Receptors

1999 • 228 citations

Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression

2006 • 224 citations

Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

2005 • 218 citations

Dopamine D₁Activation Potentiates Striatal NMDA Receptors by Tyrosine Phosphorylation-Dependent Subunit Trafficking

2006 • 218 citations

Lateral organization of endocytic machinery in dendritic spines

2004 • 216 citations

Regulation of NMDA Receptors by Neuregulin Signaling in Prefrontal Cortex

2005 • 215 citations

KIF17 Dynamics and Regulation of NR2B Trafficking in Hippocampal Neurons

2003 • 206 citations

Experience-Dependent Plasticity in Adult Visual Cortex

2006 • 200 citations

NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1

2002 • 200 citations

Obligatory Role of NR2A for Metaplasticity in Visual Cortex

2007 • 196 citations

Evidence for Altered NMDA Receptor Function as a Basis for Metaplasticity in Visual Cortex

2003 • 194 citations

Estradiol-Induced Increase in the Magnitude of Long-Term Potentiation Is Prevented by Blocking NR2B-Containing Receptors

2006 • 189 citations

Estrogen-Induced Increase in the Magnitude of Long-Term Potentiation Occurs Only When the Ratio of NMDA Transmission to AMPA Transmission Is Increased

2005 • 186 citations

Postsynaptic Density Protein-95 Regulates NMDA Channel Gating and Surface Expression

2004 • 185 citations

C-Terminal Truncation of NR2A Subunits Impairs Synaptic But Not Extrasynaptic Localization of NMDA Receptors

2000 • 184 citations

Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors

2003 • 184 citations

Distinct triggering and expression mechanisms underlie LTD of AMPA and NMDA synaptic responses

2005 • 183 citations

Barrel Cortex Critical Period Plasticity Is Independent of Changes in NMDA Receptor Subunit Composition

2001 • 182 citations

NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses

2001 • 181 citations

Separable features of visual cortical plasticity revealed by N -methyl- <scp>d</scp> -aspartate receptor 2A signaling

2003 • 180 citations

Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice

2002 • 179 citations

Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation

1994 • 173 citations

Activation of NR2A-Containing NMDA Receptors Is Not Obligatory for NMDA Receptor-Dependent Long-Term Potentiation

2005 • 170 citations

Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly

2004 • 169 citations

Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation

2004 • 167 citations

Chronic Ethanol Induces Synaptic But Not Extrasynaptic Targeting of NMDA Receptors

2004 • 163 citations

A proportional but slower NMDA potentiation follows AMPA potentiation in LTP

2004 • 162 citations

Differential regulation of synaptic and extra-synaptic NMDA receptors

2002 • 160 citations

A Molecular Mechanism for Stabilization of Learning-Induced Synaptic Modifications

2004 • 157 citations

Assembly intracellular targeting and cell surface expression of the human N-methyl-d-aspartate receptor subunits NR1a and NR2A in transfected cells

1998 • 152 citations

Rapid Synaptic Remodeling by Protein Kinase C: Reciprocal Translocation of NMDA Receptors and Calcium/Calmodulin-Dependent Kinase II

2002 • 152 citations

NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity

2006 • 150 citations

State-Dependent Heterogeneity in Synaptic Depression between Pyramidal Cell Pairs

2002 • 149 citations

Impaired NMDA Receptor-Mediated Postsynaptic Function and Blunted NMDA Receptor-Dependent Persistent Pain in Mice Lacking Postsynaptic Density-93 Protein

2003 • 148 citations

Differential Surface Expression and Phosphorylation of the N-Methyl-D-aspartate Receptor Subunits NR1 and NR2 in Cultured Hippocampal Neurons

1997 • 142 citations

Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D₅Receptor-Dependent Redistribution of NMDA Receptors

2006 • 142 citations

cAMP-Dependent Protein Kinase Mediates Activity-Regulated Synaptic Targeting of NMDA Receptors

2001 • 140 citations

Synapse-Specific Downregulation of NMDA Receptors by Early Experience: A Critical Period for Plasticity of Sensory Input to Olfactory Cortex

2005 • 139 citations

Role of the Carboxy-Terminal Region of the GluRε2 Subunit in Synaptic Localization of the NMDA Receptor Channel

1998 • 133 citations

Independent mechanisms for long-term depression of AMPA and NMDA responses

1995 • 132 citations

mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression

2005 • 122 citations

Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals

2004 • 118 citations

Protein kinase C potentiation of N -methyl- <scp>d</scp> -aspartate receptor activity is not mediated by phosphorylation of N -methyl- <scp>d</scp> -aspartate receptor subunits

1999 • 116 citations

Activation of Metabotropic Glutamate Receptor 1 Accelerates NMDA Receptor Trafficking

2001 • 112 citations

Co-stimulation of mGluR5 and N-Methyl-D-aspartate Receptors Is Required for Potentiation of Excitatory Synaptic Transmission in Hippocampal Neurons

2003 • 111 citations

PSD-95 and PKC converge in regulating NMDA receptor trafficking and gating

2006 • 107 citations

The Relative Contribution of NMDA Receptor Channels in the Expression of Long-term Potentiation in the Hippocampal CA1 Region

1992 • 107 citations

Long-Term Depression of NMDA Receptor-Mediated Synaptic Transmission Is Dependent on Activation of Metabotropic Glutamate Receptors and Is Altered to Long-Term Potentiation by Low Intracellular Calcium Buffering

2006 • 105 citations

Regulation of NMDA receptor trafficking and function by striatal‐enriched tyrosine phosphatase (STEP)

2006 • 105 citations

Rapid acquisition of dendritic spines by visual thalamic neurons after blockade of N-methyl-D-aspartate receptors.

1995 • 101 citations

N-Methyl-D-aspartate receptors are clustered and immobilized on dendrites of living cortical neurons.

1993 • 93 citations

Export from the Endoplasmic Reticulum of Assembled N-Methyl-D-aspartic Acid Receptors Is Controlled by a Motif in the C Terminus of the NR2 Subunit

2004 • 84 citations

Ethanol Alters Trafficking and Functional N-Methyl-D-aspartate Receptor NR2 Subunit Ratio via H-Ras

2005 • 84 citations

PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat

2003 • 83 citations

Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95

2003 • 75 citations

PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat

2003 • 67 citations

Dissociation of experience-dependent and -independent changes in excitatory synaptic transmission during development of barrel cortex

2004 • 66 citations

Long‐term Potentiation of NMDA Receptor‐mediated EPSP in Guinea‐pig Hippocampal Slices

1991 • 65 citations

Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state

2005 • 59 citations

Neuroanatomy

1997 • 56 citations

Expression of LTP by AMPA and/or NMDA receptors is determined by the extent of NMDA receptors activation during the tetanus

1995 • 50 citations

A Three Amino Acid Tail Following the TM4 Region of the N-Methyl-D-aspartate Receptor (NR) 2 Subunits Is Sufficient to Overcome Endoplasmic Reticulum Retention of NR1-1a Subunit

2007 • 41 citations

Afferent high strength tetanizations favour potentiation of the NMDA vs. AMPA receptor-mediated component of field EPSP in CA1 hippocampal slices of rats

2000 • 16 citations