Metaplasticity: the plasticity of synaptic plasticity

Synaptic plasticity: LTP and LTD

1994 • 1,301 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

GABAB autoreceptors regulate the induction of LTP

1991 • 613 citations

Bidirectional long-term modification of synaptic effectiveness in the adult and immature hippocampus

1993 • 590 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

The CaM kinase II hypothesis for the storage of synaptic memory

1994 • 510 citations

Dual role of calmodulin in autophosphorylation of multifunctional cam kinase may underlie decoding of calcium signals

1994 • 508 citations

A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation

1994 • 405 citations

The Influence of Prior Synaptic Activity on the Induction of Long-Term Potentiation

1992 • 398 citations

Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus

1991 • 370 citations

Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices

1991 • 356 citations

Protein kinase C modulation of NMDA currents: an important link for LTP induction

1992 • 350 citations

Postsynaptic factors control the duration of synaptic enhancement in area CA1 of the hippocampus

1991 • 319 citations

The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus

1980 • 315 citations

Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation

1990 • 303 citations

Low-frequency stimulation erases LTP through an NMDA receptor-mediated activation of protein phosphatases.

1994 • 281 citations

Presynaptic release probability influences the locus of long-term potentiation

1992 • 278 citations

Biophysical model of a Hebbian synapse.

1990 • 242 citations

Mechanism for a sliding synaptic modification threshold

1995 • 239 citations

GABAergic and developmental influences on homosynaptic LTD and depotentiation in rat hippocampus

1995 • 236 citations

Inhibition of Long-Term Potentiation by NMDA-Mediated Nitric Oxide Release

1992 • 233 citations

An investigation of depotentiation of longterm potentiation in the CA1 region of the hippocampus

1994 • 195 citations

Spatial and temporal changes in signal transduction pathways during LTP

1994 • 184 citations

Priming of associative long-term depression in the dentate gyrus by θ frequency synaptic activity

1992 • 177 citations

Long-lasting enhancement of NMDA receptor-mediated synaptic transmission by metabotropic glutamate receptor activation

1994 • 173 citations

Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation.

1986 • 168 citations

Stimulus-induced coordinate changes in mRNA abundance in single postsynaptic hippocampal CA1 neurons

1992 • 159 citations

Concerted regulation of protein phosphorylation and dephosphorylation by calmodulin

1991 • 155 citations

Low-frequency activation of the NMDA receptor system can prevent the induction of LTP

1989 • 154 citations

Insights into associative long-term potentiation from computational models of NMDA receptor-mediated calcium influx and intracellular calcium concentration changes

1990 • 153 citations

Reversal of LTP by theta frequency stimulation

1993 • 144 citations

Isolated NMDA receptor-mediated synaptic responses express both LTP and LTD

1992 • 133 citations

Independent mechanisms for long-term depression of AMPA and NMDA responses

1995 • 132 citations

Priming of homosynaptic long-term depression in hippocampus by previous synaptic activity

1993 • 122 citations

Age-dependent long-term potentiation of inhibitory synaptic transmission in rat visual cortex

1994 • 122 citations

Anoxic LTP sheds light on the multiple facets of NMDA receptors

1994 • 121 citations

Regulation of excitatory transmission at hippocampal synapses by calbindin D28k.

1995 • 119 citations

The Relative Contribution of NMDA Receptor Channels in the Expression of Long-term Potentiation in the Hippocampal CA1 Region

1992 • 107 citations

Up regulation of calbindin-D28K mRNA in the rat hippocampus following focal stimulation of the perforant path

1991 • 104 citations

Activation of metabotropic glutamate receptors induces long-term depression of GABAergic inhibition in hippocampus

1993 • 97 citations

Synaptic disinhibition during maintenance of long-term potentiation in the CA1 hippocampal subfield.

1994 • 94 citations

Synaptic potentiation of dual‐component excitatory postsynaptic currents in the rat hippocampus.

1995 • 94 citations

NMDA‐dependent heterosynaptic long‐term depression in the dentate gyrus of anaesthetized rats

1992 • 89 citations

A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.

1994 • 89 citations

Asymptotic hippocampal long-term potentiation in rats does not preclude additional potentiation at later phases

1995 • 88 citations

Reduction of the threshold for long‐term potentiation by prior theta‐frequency synaptic activity

1995 • 83 citations

Initial synaptic efficacy influences induction and expression of long-term changes in transmission.

1991 • 78 citations

Visual experience regulates gene expression in the developing striate cortex.

1989 • 75 citations

Long‐term Depression in the Hippocampal CA1 Region is Associated with Equal Changes in AMPA and NMDA Receptor‐mediated Synaptic Potentials

1994 • 49 citations

d-2-amino-5-phosphonovaleate blocks induction of long-term depression of the NMDA receptor-mediated synaptic component in rat hippocampus

1993 • 24 citations