AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss

Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy

2012 • 10,051 citations

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

A simple method for organotypic cultures of nervous tissue

1991 • 3,075 citations

Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins

1998 • 2,538 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

1992 • 1,675 citations

Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

2004 • 1,637 citations

APP Processing and Synaptic Function

2003 • 1,575 citations

Driving AMPA Receptors into Synapses by LTP and CaMKII: Requirement for GluR1 and PDZ Domain Interaction

2000 • 1,507 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Regulation of NMDA receptor trafficking by amyloid-β

2005 • 1,484 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

Morphological Changes in Dendritic Spines Associated with Long-Term Synaptic Plasticity

2001 • 1,236 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

2005 • 1,206 citations

Structure and Function of Dendritic Spines

2002 • 1,191 citations

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

2005 • 1,164 citations

Transient and Persistent Dendritic Spines in the Neocortex In Vivo

2005 • 1,127 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Mechanisms underlying induction of homosynaptic long-term depression in area CA1 of the hippocampus

1992 • 1,088 citations

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation.

1992 • 1,080 citations

Subunit-Specific Rules Governing AMPA Receptor Trafficking to Synapses in Hippocampal Pyramidal Neurons

2001 • 1,073 citations

Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression

1994 • 1,063 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Shrinkage of Dendritic Spines Associated with Long-Term Depression of Hippocampal Synapses

2004 • 989 citations

Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation [published erratum appears in J Neurosci 1992 Aug;12(8):following table of contents]

1992 • 940 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

The metabotropic glutamate receptor (mGluRlα) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction

1993 • 905 citations

Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics

2003 • 811 citations

Cell Type and Pathway Dependence of Synaptic AMPA Receptor Number and Variability in the Hippocampus

1998 • 798 citations

Importance of AMPA Receptors for Hippocampal Synaptic Plasticity But Not for Spatial Learning

1999 • 794 citations

Ras and Rap Control AMPA Receptor Trafficking during Synaptic Plasticity

2002 • 756 citations

Postsynaptic Receptor Trafficking Underlying a Form of Associative Learning

2005 • 750 citations

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

2002 • 729 citations

Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD

2000 • 728 citations

Postsynaptic Signaling and Plasticity Mechanisms

2002 • 713 citations

Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity

1999 • 690 citations

Regulation of AMPA Receptor–Mediated Synaptic Transmission by Clathrin-Dependent Receptor Internalization

2000 • 687 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

Development of Long-Term Dendritic Spine Stability in Diverse Regions of Cerebral Cortex

2005 • 672 citations

Altered expression of synaptic proteins occurs early during progression of Alzheimer’s disease

2001 • 666 citations

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

1999 • 664 citations

Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons

2001 • 657 citations

Bidirectional Activity-Dependent Morphological Plasticity in Hippocampal Neurons

2004 • 587 citations

Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

2000 • 550 citations

Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches

2004 • 548 citations

Dendritic Spine Abnormalities in Amyloid Precursor Protein Transgenic Mice Demonstrated by Gene Transfer and Intravital Multiphoton Microscopy

2005 • 544 citations

Phosphorylation of the AMPA Receptor Subunit GluR2 Differentially Regulates Its Interaction with PDZ Domain-Containing Proteins

2000 • 542 citations

Internalization of ionotropic glutamate receptors in response to mGluR activation

2001 • 540 citations

Serum‐free B27/neurobasal medium supports differentiated growth of neurons from the striatum, substantia nigra, septum, cerebral cortex, cerebellum, and dentate gyrus

1995 • 536 citations

Regulation of AMPA receptor lateral movements

2002 • 518 citations

A persistent postsynaptic modification mediates long-term potentiation in the hippocampus

1988 • 496 citations

Postsynaptic Induction and Presynaptic Expression of Hippocampal Long-Term Depression

1994 • 481 citations

Molecular Mechanisms Underlying Emotional Learning and Memory in the Lateral Amygdala

2004 • 481 citations

Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation

2006 • 478 citations

Role of p38 and JNK Mitogen-Activated Protein Kinases in the Activation of Ternary Complex Factors

1997 • 467 citations

Rapid redistribution of glutamate receptors contributes to long-term depression in hippocampal cultures

1999 • 462 citations

Clathrin Adaptor AP2 and NSF Interact with Overlapping Sites of GluR2 and Play Distinct Roles in AMPA Receptor Trafficking and Hippocampal LTD

2002 • 437 citations

Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase 5, and p38 Mitogen-Activated Protein Kinase as well as Metabotropic Glutamate Receptor Type 5

2004 • 433 citations

Alzheimer's disease and Aβ toxicity: from top to bottom

2001 • 396 citations

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

1993 • 388 citations

Chemical Induction of mGluR5- and Protein Synthesis–Dependent Long-Term Depression in Hippocampal Area CA1

2001 • 384 citations

Cerebellar Long-Term Depression Requires PKC-Regulated Interactions between GluR2/3 and PDZ Domain–Containing Proteins

2000 • 381 citations

Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses

2005 • 374 citations

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

1997 • 367 citations

Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression

2001 • 361 citations

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

1994 • 338 citations

The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus

1997 • 330 citations

Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns

1997 • 309 citations

Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2

2003 • 302 citations

Hippocampal LTD Expression Involves a Pool of AMPARs Regulated by the NSF–GluR2 Interaction

1999 • 290 citations

Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons

2004 • 277 citations

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1999 • 273 citations

Soluble β-Amyloid_1-40Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses

2005 • 271 citations

Dendrite and dendritic spine alterations in alzheimer models

2004 • 243 citations

Removal of AMPA Receptors (AMPARs) from Synapses Is Preceded by Transient Endocytosis of Extrasynaptic AMPARs

2004 • 241 citations

Block of LTP in rat hippocampus in vivo by β-amyloid precursor protein fragments

1997 • 233 citations

Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3–CA1 synapses

2000 • 223 citations

Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells

2003 • 223 citations

Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype

2003 • 222 citations

NMDA Receptor-Dependent Activation of the Small GTPase Rab5 Drives the Removal of Synaptic AMPA Receptors during Hippocampal LTD

2005 • 220 citations

AMPA receptor downscaling at the onset of Alzheimer’s disease pathology in double knockin mice

2006 • 214 citations

Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus

1996 • 212 citations

Cortical Synaptic IntegrationIn VivoIs Disrupted by Amyloid-β Plaques

2004 • 203 citations

Rap1-induced p38 Mitogen-activated Protein Kinase Activation Facilitates AMPA Receptor Trafficking via the GDI·Rab5 Complex

2004 • 181 citations

Use-Dependent Effects of Amyloidogenic Fragments of β-Amyloid Precursor Protein on Synaptic Plasticity in Rat HippocampusIn Vivo

2001 • 177 citations

Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors

2001 • 172 citations

Behavioral phenotypes of amyloid‐based genetically modified mouse models of Alzheimer's disease

2005 • 170 citations

Blockade of Long-Term Potentiation by β-Amyloid Peptides in the CA1 Region of the Rat Hippocampus In Vivo

2001 • 148 citations

Independent mechanisms for long-term depression of AMPA and NMDA responses

1995 • 132 citations

Group I Metabotropic Glutamate Receptor (mGluR)-Dependent Long-Term Depression Mediated via p38 Mitogen-Activated Protein Kinase Is Inhibited by Previous High-Frequency Stimulation and Activation of mGluRs and Protein Kinase C in the Rat Dentate GyrusIn Vitro

2002 • 120 citations

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

1994 • 98 citations

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice

2000 • 70 citations

Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage

2004 • 68 citations

β-Amyloid Peptides Impair PKC-Dependent Functions of Metabotropic Glutamate Receptors in Prefrontal Cortical Neurons

2005 • 47 citations

Alterations in glutamate receptor 2/3 subunits and amyloid precursor protein expression during the course of Alzheimer's disease and Lewy body variant

1997 • 45 citations