Impaired mammary gland and lymphoid development caused by inducible expression of Axin in transgenic mice

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Wnt signaling and cancer

2000 • 3,215 citations

Functional interaction of β-catenin with the transcription factor LEF-1

1996 • 2,847 citations

β-catenin is a target for the ubiquitin–proteasome pathway

1997 • 2,461 citations

Transcriptional Activation by Tetracyclines in Mammalian Cells

1995 • 2,458 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

MECHANISMS OF WNT SIGNALING IN DEVELOPMENT

1998 • 2,028 citations

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

1996 • 1,827 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Wnt Signaling in Oncogenesis and Embryogenesis--a Look Outside the Nucleus

2000 • 1,253 citations

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

1998 • 1,241 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin

1998 • 1,082 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.

1994 • 969 citations

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

2000 • 943 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

1999 • 888 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

The Wnt/Ca2+ pathway

2000 • 843 citations

Target genes of β-catenin–T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas

1999 • 807 citations

Wnt genes

1992 • 799 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca2+ pathways

1999 • 699 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]

1991 • 627 citations

Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box.

1991 • 545 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

SELECTION OF THE T CELL REPERTOIRE

1999 • 507 citations

Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling

2000 • 476 citations

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

2000 • 444 citations

Casein kinase I transduces Wnt signals

1999 • 443 citations

Transformation by Wnt family proteins correlates with regulation of beta-catenin.

1997 • 412 citations

Axin and Frat1 interact with Dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1

1999 • 409 citations

WNT-1 Signaling Inhibits Apoptosis by Activating β-Catenin/T Cell Factor–Mediated Transcription

2001 • 379 citations

A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer.

1991 • 372 citations

Wnt-induced dephosphorylation of Axin releases beta -catenin from the Axin complex

1999 • 345 citations

Differential Transformation of Mammary Epithelial Cells by Wnt Genes

1994 • 305 citations

Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation

1995 • 285 citations

A mutation in the Gsk3–binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon

2001 • 267 citations

Domains of Axin Involved in Protein–Protein Interactions, Wnt Pathway Inhibition, and Intracellular Localization

1999 • 267 citations

Identification of a Domain of Axin That Binds to the Serine/Threonine Protein Phosphatase 2A and a Self-binding Domain

1999 • 260 citations

Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and β-catenin

1998 • 258 citations

Regulation of β-Catenin Signaling in the Wnt Pathway

2000 • 256 citations

Interaction of Axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription

1999 • 251 citations

The β-catenin–TCF-1 pathway ensures CD4+CD8+ thymocyte survival

2001 • 241 citations

Δn89β-Catenin Induces Precocious Development, Differentiation, and Neoplasia in Mammary Gland

2001 • 200 citations

Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis

1999 • 185 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

Interaction among Gsk-3, Gbp, Axin, and APC in Xenopus Axis Specification

2000 • 162 citations

Wnt-10b directs hypermorphic development and transformation in mammary glands of male and female mice

1997 • 145 citations

New Aspects of Stroma-Parenchyma Relations in Mammary Gland Differentiation

1991 • 140 citations

Conditional gene expression in secretory tissues and skin of transgenic mice using the MMTV‐LTR and the tetracycline responsive system

1995 • 129 citations

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling

1999 • 128 citations

Notch4 and Wnt-1 Proteins Function to Regulate Branching Morphogenesis of Mammary Epithelial Cells in an Opposing Fashion

1998 • 126 citations

Inducible gene expression in mammalian cells and transgenic mice

1997 • 121 citations

The effects of a lethal mutation responsible for duplications and twinning in mouse embryos

1949 • 112 citations

Phenotypic and molecular analysis of a transgenic insertional allele of the mouse Fused locus.

1995 • 103 citations

Wnt-1 dependent activation of the survival factor NF-?B in PC12 cells

2000 • 101 citations

Side-branching in the mammary gland: the progesterone–Wnt connection

2000 • 89 citations

Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

1999 • 82 citations

Cross-regulation of the Wnt signalling pathway: a role of MAP kinases

2000 • 78 citations

Domains of Axin and Disheveled Required for Interaction and Function in Wnt Signaling

2000 • 72 citations

Axin-Induced Apoptosis Depends on the Extent of Its JNK Activation and Its Ability to Down-Regulate β-Catenin Levels

2000 • 51 citations

Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells.

1993 • 44 citations

Knobbly, a new dominant mutation in the mouse that affects embryonic ectoderm organization

1984 • 40 citations

Convergent Regulation of NF-IL6 and Oct-1 Synthesis by Interleukin-6 and Retinoic Acid Signaling in Embryonal Carcinoma Cells

1993 • 10 citations