Activation of the cyclin D1 Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

1997 • 4,870 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

1996 • 2,873 citations

The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway

1999 • 2,206 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Histone acetylation and transcriptional regulatory mechanisms

1998 • 1,793 citations

Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

1997 • 1,568 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

Nuclear protein CBP is a coactivator for the transcription factor CREB

1994 • 1,447 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Cytometry in cell necrobiology: Analysis of apoptosis and accidental cell death (necrosis)

1997 • 1,082 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor.

1994 • 1,046 citations

Cyclin D1 provides a link between development and oncogenesis in the retina and breast

1995 • 1,017 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

1998 • 984 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

Transforming p21 Mutants and c-Ets-2 Activate the Cyclin D1 Promoter through Distinguishable Regions

1995 • 803 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Activation of cAMP and mitogen responsive genes relies on a common nuclear factor

1994 • 730 citations

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

1995 • 681 citations

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.

1993 • 677 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

1999 • 662 citations

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

1990 • 654 citations

E1A signaling to p53 involves the p19^ARFtumor suppressor

1998 • 614 citations

Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

1995 • 578 citations

Control of cell cycle progression by c-Jun is p53 dependent

1999 • 562 citations

Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

1994 • 538 citations

Function of a human cyclin gene as an oncogene.

1994 • 471 citations

Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene.

1994 • 460 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.

1994 • 432 citations

Cyclin D1 is an essential mediator of apoptotic neuronal cell death.

1996 • 383 citations

Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

1995 • 363 citations

The Cyclins and Cyclin-Dependent Kinase Inhibitors in Hormonal Regulation of Proliferation and Differentiation*

1999 • 358 citations

CBP as a transcriptional coactivator of c-Myb.

1996 • 347 citations

CBP-induced stimulation of c-Fos activity is abrogated by E1A.

1995 • 342 citations

Convergence of Mitogenic Signalling Cascades from Diverse Classes of Receptors at the Cyclin D–Cyclin-Dependent Kinase–pRb-Controlled G₁ Checkpoint

1996 • 331 citations

Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation

1998 • 330 citations

Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations.

1991 • 309 citations

Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts.

1994 • 296 citations

Ras Transformation Results in an Elevated Level of Cyclin D1 and Acceleration of G₁ Progression in NIH 3T3 cells

1995 • 276 citations

Identification of specific adenovirus E1A N-terminal residues critical to the binding of cellular proteins and to the control of cell growth

1993 • 254 citations

Repression of cyclin D1: a novel function of MYC.

1994 • 250 citations

Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter

1996 • 248 citations

Fos Family Members Induce Cell Cycle Entry by Activating Cyclin D1

1998 • 241 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo

1998 • 230 citations

pp60v- Induction of Cyclin D1 Requires Collaborative Interactions between the Extracellular Signal-regulated Kinase, p38, and Jun Kinase Pathways

1999 • 227 citations

Differential Use of CREB Binding Protein-Coactivator Complexes

1998 • 218 citations

Induction of cyclin D1 by simian virus 40 small tumor antigen

1996 • 209 citations

Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins.

1992 • 198 citations

Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

1995 • 191 citations

Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.

1991 • 161 citations

Inhibition of Cyclin D1 Kinase Activity Is Associated with E2F-Mediated Inhibition of Cyclin D1 Promoter Activity through E2F and Sp1

1998 • 160 citations

Quantification of apoptotic cells with fluorescein isothiocyanate-labeled annexin V in chinese hamster ovary cell cultures treated with cisplatin

1996 • 158 citations

Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300

1996 • 156 citations

p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis.

1995 • 155 citations

Increased expression of cyclin D1 in a murine mammary epithelial cell line induces p27kip1, inhibits growth, and enhances apoptosis.

1996 • 145 citations

Angiotensin II Activation of Cyclin D1-dependent Kinase Activity

1996 • 139 citations

Rescue of cells from ras oncogene-induced growth arrest by a second, complementing, oncogene.

1988 • 136 citations

Use of a membrane-localized green fluorescent protein allows simultaneous identification of transfected cells and cell cycle analysis by flow cytometry

1997 • 132 citations

Selective induction of p53 and chemosensitivity in RB-deficient cells by E1A mutants unable to bind the RB-related proteins

1997 • 103 citations

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.

1991 • 102 citations

A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice

1998 • 96 citations

Transforming Potential of Dbl Family Proteins Correlates with Transcription from the Cyclin D1 Promoter but Not with Activation of Jun NH2-terminal Kinase, p38/Mpk2, Serum Response Factor, or c-Jun

1998 • 88 citations

The ts13 Mutation in the TAF_II250 Subunit (CCG1) of TFIID Directly Affects Transcription of D-Type Cyclin Genes in Cells Arrested in G₁ at the Nonpermissive Temperature

1997 • 81 citations

Suppression of the p300-dependent mdm2negative-feedback loop induces the p53 apoptotic function

1998 • 74 citations

Critical aspects in the analysis of apoptosis and necrosis.

1998 • 72 citations

Cyclin D1 and p21/waf1 are both involved in p53 growth suppression.

1996 • 68 citations

E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity

1995 • 64 citations

Modulation of cyclin gene expression by adenovirus E1A in a cell line with E1A-dependent conditional proliferation

1994 • 61 citations

Biological response to phorbol ester determined by alternative G1 pathways.

1995 • 59 citations

Rapid generation and flow cytometric analysis of stable GFP-expressing cells

1996 • 52 citations

Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A

1996 • 48 citations

Inhibition of p53-Mediated Growth Arrest by Overexpression of Cyclin-Dependent Kinases

1996 • 37 citations

Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways.

1996 • 36 citations

Adenovirus E1A activates cyclin A gene transcription in the absence of growth factors through interaction with p107

1996 • 35 citations

The role of p53 in coordinated regulation of cyclin D1 and p21 gene expression by the adenovirus E1A and E1B oncogenes.

1995 • 25 citations

A potential role for cell cycle control proteins in regulation of the cyclic adenosine 5'-monophosphate-responsive glycoprotein hormone alpha subunit gene.

1996 • 9 citations