Pushing the limits of the scanning mechanism for initiation of translation

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

The alphaviruses: gene expression, replication, and evolution

1994 • 1,952 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Initiation of translation in prokaryotes and eukaryotes

1999 • 1,379 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

At least six nucleotides preceding the AUG initiator codon enhance translation in mammalian cells

1987 • 1,189 citations

The Molecular Biology of Coronaviruses

1997 • 1,157 citations

Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

2001 • 1,113 citations

A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the sam mRNA

1991 • 1,019 citations

A novel influenza A virus mitochondrial protein that induces cell death

2001 • 1,006 citations

Internal ribosome entry sites in eukaryotic mRNA molecules

2001 • 975 citations

Nonsense-mediated mRNA decayin health and disease

1999 • 974 citations

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

2001 • 900 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Interpreting cDNA sequences: Some insights from studies on translation

1996 • 785 citations

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

2002 • 751 citations

Molecular mechanisms of translation initiation in eukaryotes

2001 • 730 citations

Upstream Open Reading Frames as Regulators of mRNA Translation

2000 • 728 citations

Gene-Specific Regulation by General Translation Factors

2002 • 720 citations

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

1995 • 690 citations

Influences of mRNA secondary structure on initiation by eukaryotic ribosomes.

1986 • 684 citations

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

1989 • 618 citations

Regulation of alternative splicing by RNA editing

1999 • 614 citations

Inducibility and negative autoregulation of CREM: An alternative promoter directs the expression of ICER, an early response repressor

1993 • 592 citations

Downstream secondary structure facilitates recognition of initiator codons by eukaryotic ribosomes.

1990 • 550 citations

Effects of Intercistronic Length on the Efficiency of Reinitiation by Eucaryotic Ribosomes

1987 • 540 citations

Translational Regulation of Yeast GCN4

1997 • 533 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

Recognition of AUG and alternative initiator codons is augmented by G in position +4 but is not generally affected by the nucleotides in positions +5 and +6

1997 • 486 citations

Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

2001 • 472 citations

β-catenin–sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer

2001 • 457 citations

Structural and functional features of eukaryotic mRNA untranslated regions

2001 • 411 citations

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

2000 • 405 citations

Translational control of C/EBP alpha and C/EBP beta isoform expression

2000 • 403 citations

Translational control of C/EBPα and C/EBPβ isoform expression

2000 • 402 citations

Viral and cellular mRNA capping: Past and prospects

2000 • 387 citations

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

2001 • 373 citations

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

1995 • 372 citations

CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials.

1993 • 372 citations

Caveolin Isoforms Differ in Their N-terminal Protein Sequence and Subcellular Distribution. IDENTIFICATION AND EPITOPE MAPPING OF AN ISOFORM-SPECIFIC MONOCLONAL ANTIBODY PROBE

1995 • 362 citations

A global analysis of Caenorhabditis elegans operons

2002 • 359 citations

The Amphiregulin Gene Encodes a Novel Epidermal Growth Factor-Related Protein with Tumor-Inhibitory Activity

1990 • 359 citations

Mutations in each of the five subunits of translation initiation factor eIF2B can cause leukoencephalopathy with vanishing white matter

2001 • 357 citations

Zebrafish wnt8 Encodes Two Wnt8 Proteins on a Bicistronic Transcript and Is Required for Mesoderm and Neurectoderm Patterning

2001 • 340 citations

Block of HAC1 mRNA Translation by Long-Range Base Pairing Is Released by Cytoplasmic Splicing upon Induction of the Unfolded Protein Response

2001 • 328 citations

A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity.

1993 • 313 citations

Alternative transcription and splicing of the human porphobilinogen deaminase gene result either in tissue-specific or in housekeeping expression.

1988 • 313 citations

Producing Nature’s Gene-Chips: The Generation of Peptides for Display by MHC Class I Molecules

2002 • 309 citations

The HTS1 gene encodes both the cytoplasmic and mitochondrial histidine tRNA synthetases of S. cerevisiae

1986 • 308 citations

An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia

1998 • 307 citations

The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUG.

1991 • 303 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets

1981 • 290 citations

Constraints on reinitiation of translation in mammals

2001 • 287 citations

A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator

1987 • 278 citations

Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.

1987 • 277 citations

Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms

2000 • 276 citations

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma

1999 • 276 citations

Synthesis of brome mosaic virus subgenomic RNA in vitro by internal initiation on (−)-sense genomic RNA

1985 • 272 citations

Messenger RNA for the coat protein of tobacco mosaic virus

1976 • 266 citations

Utilization of an alternative open reading frame of a normal gene in generating a novel human cancer antigen.

1996 • 261 citations

A human aminoacyl-tRNA synthetase as a regulator of angiogenesis

2002 • 258 citations

Regulation of vascular endothelial growth factor (VEGF) expression is mediated by internal initiation of translation and alternative initiation of transcription

1998 • 256 citations

Adherence to the first-AUG rule when a second AUG codon follows closely upon the first.

1995 • 254 citations

pVHL ₁₉ is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation

1998 • 248 citations

Introducing RefSeq and LocusLink: curated human genome resources at the NCBI

2000 • 247 citations

Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.

1991 • 243 citations

The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.

1990 • 241 citations

The Vitamin D Receptor Gene Start Codon Polymorphism: A Functional Analysis of FokI Variants

1998 • 236 citations

A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation

2001 • 234 citations

A New 34-Kilodalton Isoform of Human Fibroblast Growth Factor 2 Is Cap Dependently Synthesized by Using a Non-AUG Start Codon and Behaves as a Survival Factor

1999 • 228 citations

A second major native von Hippel–Lindau gene product, initiated from an internal translation start site, functions as a tumor suppressor

1998 • 226 citations

Bunyamwera bunyavirus nonstructural protein NSs is a nonessential gene product that contributes to viral pathogenesis

2001 • 226 citations

Posttranscriptional Control of Gene Expression in Yeast

1998 • 225 citations

Initiation Factor eIF2α Phosphorylation in Stress Responses and Apoptosis

2001 • 216 citations

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

2001 • 214 citations

Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon

2002 • 214 citations

Translational pathophysiology: a novel molecular mechanism of human disease

2000 • 213 citations

A Complex Translational Program Generates Multiple Novel Proteins from the Latently Expressed Kaposin (K12) Locus of Kaposi’s Sarcoma-Associated Herpesvirus

1999 • 213 citations

Molecular Biology of Luteoviruses

1996 • 213 citations

GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation inSaccharomyces cerevisiae

1997 • 209 citations

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

1997 • 208 citations

Complete genomic sequence of the human ABCA1 gene: Analysis of the human and mouse ATP-binding cassette A promoter

2000 • 206 citations

Translational activation of the lck proto-oncogene

1988 • 203 citations

Migration of 40 S ribosomal subunits on messenger RNA in the presence of edeine.

1978 • 201 citations

Synthesis of Subgenomic RNAs by Positive-Strand RNA Viruses

2000 • 200 citations

tRNA _i ^met Functions in Directing the Scanning Ribosome to the Start Site of Translation

1988 • 199 citations

Rat Phospholipid-hydroperoxide Glutathione Peroxidase

1995 • 198 citations

New Ways of Initiating Translation in Eukaryotes?

2001 • 196 citations

The yeast VAS1 gene encodes both mitochondrial and cytoplasmic valyl-tRNA synthetases.

1988 • 196 citations

A short leader sequence impairs the fidelity of initiation by eukaryotic ribosomes.

1991 • 196 citations

Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation

1997 • 195 citations

The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain.

1996 • 193 citations

An imprinted, mammalian bicistronic transcript encodes two independent proteins

1999 • 189 citations

A Common Genetic Polymorphism (46 C to T Substitution) in the 5′-Untranslated Region of the Coagulation Factor XII Gene Is Associated With Low Translation Efficiency and Decrease in Plasma Factor XII Level

1998 • 188 citations

CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

1997 • 185 citations

RNA diversity has profound effects on the translation of neuronal nitric oxide synthase

1999 • 182 citations

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.

1991 • 182 citations

The 5′ Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Transcript Is a Potent Translational Inhibitor

1988 • 180 citations

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

1995 • 178 citations

Targeting of a Human Iron–Sulfur Cluster Assembly Enzyme, nifs, to Different Subcellular Compartments Is Regulated through Alternative AUG Utilization

1998 • 177 citations

Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs

2001 • 177 citations

Expression of NFAT-Family Proteins in Normal Human T Cells

1997 • 176 citations

Familial Essential Thrombocythemia Associated With One-Base Deletion in the 5′-Untranslated Region of theThrombopoietin Gene

1998 • 170 citations

A Plant Viral “Reinitiation” Factor Interacts with the Host Translational Machinery

2001 • 169 citations

Molecular Cloning of the Human p120ctnCatenin Gene (CTNND1): Expression of Multiple Alternatively Spliced Isoforms

1998 • 168 citations

Growth-dependent translation of IGF-II mRNA by a rapamycin-sensitive pathway

1995 • 165 citations

Genomic organization and biosynthesis of secreted and cytoplasmic forms of gelsolin

1988 • 165 citations

The secreted form of invertase in Saccharomyces cerevisiae is synthesized from mRNA encoding a signal sequence.

1983 • 164 citations

The Arabidopsis thaliana FPS1 Gene Generates a Novel mRNA That Encodes a Mitochondrial Farnesyl-diphosphate Synthase Isoform

1997 • 163 citations

Internal initiation of translation of five dendritically localized neuronal mRNAs

2001 • 160 citations

Kozak Sequence Polymorphism of the Glycoprotein (GP) Ib Gene Is a Major Determinant of the Plasma Membrane Levels of the Platelet GP Ib-IX-V Complex

1999 • 160 citations

Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region.

1990 • 154 citations

Fibroblast Growth Factor 2 Internal Ribosome Entry Site (Ires) Activity Ex Vivo and in Transgenic Mice Reveals a Stringent Tissue-Specific Regulation

2000 • 153 citations

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2.

1993 • 152 citations

ERα Gene Expression in Human Primary Osteoblasts: Evidence for the Expression of Two Receptor Proteins

2001 • 152 citations

The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame

1991 • 152 citations

Role of ATP in binding and migration of 40S ribosomal subunits

1980 • 149 citations

Presence of ATG triplets in 5′ untranslated regions of eukaryotic cDNAs correlates with a ‘weak’ context of the start codon

2001 • 149 citations

Molecular Identification and Characterization of A and B Forms of the Glucocorticoid Receptor

2001 • 148 citations

Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1

1991 • 147 citations

CHOP-Dependent Stress-Inducible Expression of a Novel Form of Carbonic Anhydrase VI

1999 • 146 citations

Transient expression of human and chicken progesterone receptors does not support alternative translational initiation from a single mRNA as the mechanism generating two receptor isoforms.

1990 • 146 citations

Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor.

1995 • 145 citations

Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization

2001 • 145 citations

Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7.

1992 • 144 citations

Physical evidence for distinct mechanisms of translational control by upstream open reading frames

2001 • 143 citations

Expression of the Open Reading Frame 74 (G-Protein-Coupled Receptor) Gene of Kaposi’s Sarcoma (KS)-Associated Herpesvirus: Implications for KS Pathogenesis

1999 • 143 citations

Inability of circular mRNA to attach to eukaryotic ribosomes

1979 • 143 citations

Mutational Analysis of the HIS4 Translational Initiator Region in Saccharomyces cerevisiae

1988 • 142 citations

Statistical Analysis of the 5′ Untranslated Region of Human mRNA Using “Oligo-Capped” cDNA Libraries

2000 • 141 citations

The human galactose-1-phosphate uridyltransferase gene

1992 • 140 citations

Position Is the Critical Determinant for Function of Iron-Responsive Elements as Translational Regulators

1992 • 138 citations

Polyamine Regulation of Ribosome Pausing at the Upstream Open Reading Frame of S-Adenosylmethionine Decarboxylase

2001 • 138 citations

mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5.

1991 • 136 citations

Identification of Downstream-Initiated c-Myc Proteins Which Are Dominant-Negative Inhibitors of Transactivation by Full-Length c-Myc Proteins

1997 • 136 citations

Human MxB Protein, an Interferon-α-inducible GTPase, Contains a Nuclear Targeting Signal and Is Localized in the Heterochromatin Region beneath the Nuclear Envelope

1996 • 135 citations

Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin gene

1999 • 134 citations

Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region.

1991 • 133 citations

Translation initiation at alternate in-frame AUG codons in the rabies virus phosphoprotein mRNA is mediated by a ribosomal leaky scanning mechanism

1995 • 129 citations

Transcriptional Regulation of the Interleukin-6 Gene of Human Herpesvirus 8 (Kaposi's Sarcoma-Associated Herpesvirus)

2002 • 128 citations

Identification of murine p120 isoforms and heterogeneous expression of p120cas isoforms in human tumor cell lines.

1996 • 127 citations

Mechanisms Governing Expression of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus

2001 • 125 citations

Effect of upstream reading frames on translation efficiency in simian virus 40 recombinants.

1986 • 125 citations

Nucleotide sequence and expression of the capsid protein gene of feline calicivirus

1991 • 124 citations

Evidence that a regulatory gene autoregulates splicing of its transcript.

1987 • 123 citations

The procaspase-8 isoform, procaspase-8L, recruited to the BAP31 complex at the endoplasmic reticulum

2002 • 123 citations

Abrogation of Upstream Open Reading Frame-mediated Translational Control of a Plant S-Adenosylmethionine Decarboxylase Results in Polyamine Disruption and Growth Perturbations

2002 • 122 citations

Mechanism of translation of monocistronic and multicistronic human immunodeficiency virus type 1 mRNAs.

1992 • 121 citations

Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.

1991 • 121 citations

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

1992 • 119 citations

Competition between nuclear localization and secretory signals determines the subcellular fate of a single CUG-initiated form of FGF3.

1994 • 119 citations

The Avian Reovirus Genome Segment S1 Is a Functionally Tricistronic Gene That Expresses One Structural and Two Nonstructural Proteins in Infected Cells

2001 • 118 citations

Two overlapping reading frames in a single exon encode interacting proteins--a novel way of gene usage

2001 • 117 citations

Calspermin Gene Transcription Is Regulated by Two Cyclic AMP Response Elements Contained in an Alternative Promoter in the Calmodulin Kinase IV Gene

1995 • 116 citations

Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation

2001 • 116 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

1994 • 115 citations

RAR-beta 4, a retinoic acid receptor isoform is generated from RAR-beta 2 by alternative splicing and usage of a CUG initiator codon.

1992 • 115 citations

A small highly basic protein is encoded in overlapping frame within the P gene of vesicular stomatitis virus

1993 • 113 citations

Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia.

1991 • 113 citations

Regulation of Gene Expression by Internal Ribosome Entry Sites or Cryptic Promoters: the eIF4G Story

2002 • 112 citations

Role of two upstream open reading frames in the translational control of oncogene mdm2

1999 • 112 citations

Internal Translation Initiation Generates Novel WT1 Protein Isoforms with Distinct Biological Properties

1999 • 112 citations

E3 Transcription Unit of Adenovirus

1995 • 111 citations

A Novel, Testis-specific mRNA Transcript Encoding an NH2-terminal Truncated Nitric-oxide Synthase

1997 • 111 citations

Structure of the 5' flanking region of the gene encoding human parathyroid-hormone-related protein (PTHrP)

1989 • 110 citations

Translational Control by an Upstream Open Reading Frame in the HER-2/neu Transcript

1999 • 110 citations

Infectious TYMV RNA from cloned cDNA: effectsin vitroandin vivoof point substitutions in the initiation codons of two extensively overlapping ORFs

1989 • 110 citations

Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex

2001 • 108 citations

C/T Polymorphism in the 5′ Untranslated Region of the Apolipoprotein(a) Gene Introduces an Upstream ATG and Reduces In Vitro Translation

1995 • 108 citations

Translational discrimination of mRNAs coding for human insulin-like growth factor II.

1990 • 108 citations

Variants of the 5′-untranslated region of the bovine growth hormone receptor mRNA: isolation, expression and effects on translational efficiency

2001 • 106 citations

An internal open reading frame triggers nonsense-mediated decay of the yeast SPT10 mRNA

1999 • 105 citations

Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site

1983 • 105 citations

A Non-AUG-Defined Alternative Open Reading Frame of the Intestinal Carboxyl Esterase mRNA Generates an Epitope Recognized by Renal Cell Carcinoma-Reactive Tumor-Infiltrating Lymphocytes In Situ

1999 • 105 citations

Transcriptional Regulation of the Interferon- γ-inducible Tryptophanyl-tRNA Synthetase Includes Alternative Splicing

1995 • 105 citations

Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP.

2002 • 105 citations

Control of start codon choice on a plant viral RNA encoding overlapping genes.

1993 • 104 citations

The Retinoblastoma Interacting Zinc Finger Gene RIZ Produces a PR Domain-lacking Product through an Internal Promoter

1997 • 103 citations

An Alternative Open Reading Frame of the Human Macrophage Colony-Stimulating Factor Gene Is Independently Translated and Codes for an Antigenic Peptide of 14 Amino Acids Recognized by Tumor-Infiltrating Cd8 T Lymphocytes

2001 • 103 citations

Interleukin-2-induced, melanoma-specific T cells recognize camel, an unexpected translation product ofLAGE-1

1999 • 103 citations

Archaeal translation initiation revisited: The initiation factor 2 and eukaryotic initiation factor 2B α-β-δ subunit families

1998 • 103 citations

Cloning, expression, and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs.

1991 • 102 citations

Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs

2001 • 101 citations

Emerging links between initiation of translation and human diseases

2002 • 101 citations

Conservation of polyamine regulation by translational frameshifting from yeast to mammals

2000 • 100 citations

Translational Control of Cell Fate: Availability of Phosphorylation Sites on Translational Repressor 4E-BP1 Governs Its Proapoptotic Potency

2002 • 100 citations

The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.

1995 • 99 citations

In Vivo Translation of the Triple Gene Block of Potato Virus X Requires Two Subgenomic mRNAs

1998 • 99 citations

A translationally regulated Tousled kinase phosphorylates histone H3 and confers radioresistance when overexpressed

2001 • 99 citations

Generation from a single gene of two mRNAs that encode the mitochondrial and peroxisomal serine:pyruvate aminotransferase of rat liver.

1990 • 99 citations

A reassessment of the translation initiation codon in vertebrates

2001 • 98 citations

Leaky Scanning Is the Predominant Mechanism for Translation of Human Papillomavirus Type 16 E7 Oncoprotein from E6/E7 Bicistronic mRNA

2000 • 98 citations

Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1

1999 • 97 citations

HCC-2, a human chemokine: Gene structure, expression pattern, and biological activity

1998 • 96 citations

Cell-to-Cell Movement of Turnip Crinkle Virus Is Controlled by Two Small Open Reading Frames That Functionin trans

1998 • 96 citations

Eukaryotic Translation Initiation Factor 5 Functions as a GTPase-activating Protein

2001 • 96 citations

The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability

1998 • 96 citations

Human Molybdopterin Synthase Gene: Identification of a Bicistronic Transcript with Overlapping Reading Frames

1999 • 95 citations

In vivo evaluation of the context sequence of the translation initiation codon in plants

2000 • 95 citations

The 5' untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor.

1988 • 94 citations

Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing.

1993 • 93 citations

Characterization of two cis-regulatory regions in the murine beta 1,4-galactosyltransferase gene. Evidence for a negative regulatory element that controls initiation at the proximal site

1993 • 92 citations

Yeast LEU4 encodes mitochondrial and nonmitochondrial forms of alpha-isopropylmalate synthase.

1988 • 92 citations

Regulatory Role of the Conserved Stem-Loop Structure at the 5′ End of Collagen α1(I) mRNA

1999 • 92 citations

c-myc Internal Ribosome Entry Site Activity Is Developmentally Controlled and Subjected to a Strong Translational Repression in Adult Transgenic Mice

2001 • 91 citations

Characterization of the gene encoding human platelet glycoprotein IX.

1993 • 91 citations

Complete testicular feminization caused by an amino-terminal truncation of the androgen receptor with downstream initiation.

1993 • 91 citations

Generation of Multiple Isoforms of Eukaryotic Translation Initiation Factor 4GI by Use of Alternate Translation Initiation Codons

2002 • 90 citations

A somatic mutation in the 5′UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency

2001 • 90 citations

Characterization of Human MAPRE Genes and Their Proteins

2001 • 89 citations

The glyoxysomal and plastid molecular chaperones (70-kDa heat shock protein) of watermelon cotyledons are encoded by a single gene

1997 • 88 citations

Cytomegalovirus assembly protein nested gene family: four 3'-coterminal transcripts encode four in-frame, overlapping proteins

1991 • 87 citations

Coupled Transcriptional and Translational Control of Cyclin-Dependent Kinase Inhibitor p18^INK4cExpression during Myogenesis

1998 • 87 citations

Pim-1 protein expression is regulated by its 5'-untranslated region and translation initiation factor elF-4E.

1997 • 87 citations

Detection of the ORF3 polypeptide of feline calicivirus in infected cells and evidence for its expression from a single, functionally bicistronic, subgenomic mRNA

1996 • 86 citations

Upstream Open Reading Frames Regulate the Translation of the Multiple mRNA Variants of the Estrogen Receptor α

2002 • 86 citations

Efficient Simultaneous Presentation of NY-ESO-1/LAGE-1 Primary and Nonprimary Open Reading Frame-Derived CTL Epitopes in Melanoma

2000 • 86 citations

Translation of the RNAs of brome mosaic virus: The monocistronic nature of RNA1 and RNA2

1976 • 86 citations

Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit

1999 • 86 citations

rlk/TXK Encodes Two Forms of a Novel Cysteine String Tyrosine Kinase Activated by Src Family Kinases

1999 • 86 citations

Tissue specific expression of the retinoic acid receptor-beta 2: regulation by short open reading frames in the 5'-noncoding region.

1994 • 85 citations

A cis-acting element in the BCL-2 gene controls expression through translational mechanisms.

1996 • 85 citations

Translation initiation start prediction in human cDNAs with high accuracy

2002 • 83 citations

Expression of the hepatitis B virus core gene in vitro and in vivo

1987 • 83 citations

Position-dependent ATT initiation during plant pararetrovirus rice tungro bacilliform virus translation

1996 • 83 citations

Splicing of cauliflower mosaic virus 35S RNA is essential for viral infectivity.

1995 • 83 citations

Regulation of Expression of the Alternative mRNAs of the Rat α-Thyroid Hormone Receptor Gene

1989 • 83 citations

The size of Rous sarcoma virus mRNAs active in cell-free translation

1977 • 83 citations

Caveolin‐1 isoforms are encoded by distinct mRNAs

2000 • 83 citations

Mutational analysis of the HIS4 translational initiator region in Saccharomyces cerevisiae.

1988 • 83 citations

Positive and Negative Regulation of Myogenic Differentiation of C2C12 Cells by Isoforms of the Multiple Homeodomain Zinc Finger Transcription Factor ATBF1

2001 • 82 citations

A Positive-Strand RNA Virus with Three Very Different Subgenomic RNA Promoters

2000 • 82 citations

Transcriptional Control of Hepadnavirus Gene Expression

1991 • 82 citations

Opposing Roles of Elk-1 and Its Brain-specific Isoform, Short Elk-1, in Nerve Growth Factor-induced PC12 Differentiation

2001 • 82 citations

Characterization of Two Novel Nuclear BTB/POZ Domain Zinc Finger Isoforms

2002 • 82 citations

Human RNA-specific adenosine deaminase (ADAR1) gene specifies transcripts that initiate from a constitutively active alternative promoter

2000 • 81 citations

Characterization of Human Mucin Gene MUC4Promoter

2001 • 80 citations

Analysis of the Two Subgenomic RNA Promoters for Turnip Crinkle Virusin Vivoandin Vitro

1997 • 80 citations

Initiation of translation directed by 42S and 26S RNAs from Semliki Forest virus in vitro.

1976 • 80 citations

Mapping of the Tobacco Mosaic Virus Movement Protein and Coat Protein Subgenomic RNA Promoters in Vivo

2000 • 79 citations

Translation of the hepatitis B virus P gene by ribosomal scanning as an alternative to internal initiation

1993 • 79 citations

The S4 Genome Segment of Baboon Reovirus Is Bicistronic and Encodes a Novel Fusion-Associated Small Transmembrane Protein

2002 • 79 citations

Specific sequences in p120ctn determine subcellular distribution of its multiple isoforms involved in cellular adhesion of normal and malignant epithelial cells

2002 • 78 citations

Splicing in a Plant Pararetrovirus

1994 • 78 citations

Identification of Two Additional Translation Products from the Matrix (M) Gene That Contribute to Vesicular Stomatitis Virus Cytopathology

2002 • 78 citations

Alternative Splicing and Promoter Usage Generates an Intracellular Stromelysin 3 Isoform Directly Translated as an Active Matrix Metalloproteinase

2002 • 77 citations

The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene

2001 • 77 citations

alpha-Thalassaemia associated with the deletion of two nucleotides at position -2 and -3 preceding the AUG codon.

1985 • 77 citations

Mechanism of Endoplasmic Reticulum Retention of Mutant Vasopressin Precursor Caused by a Signal Peptide Truncation Associated with Diabetes Insipidus

1999 • 77 citations

Position is the critical determinant for function of iron-responsive elements as translational regulators.

1992 • 77 citations

Translation of a nonpolyadenylated viral RNA is enhanced by binding of viral coat protein or polyadenylation of the RNA

2001 • 77 citations

The 5′-Untranslated Region of the N-Methyl-D-aspartate Receptor NR2A Subunit Controls Efficiency of Translation

1996 • 76 citations

DNA methylation represses the expression of the human erythropoietin gene by two different mechanisms

2000 • 76 citations

Human O-GlcNAc transferase (OGT): genomic structure, analysis of splice variants, fine mapping in Xq13.1

2002 • 76 citations

Characterization of the cis-Acting Elements Controlling Subgenomic mRNAs of Citrus tristeza virus: Production of Positive- and Negative-Stranded 3′-Terminal and Positive-Stranded 5′-Terminal RNAs

2001 • 76 citations

Significant impact of the +93 C/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: confounding effect of linkage disequilibrium

1998 • 76 citations

Molecular Characterization of Pax62Neu Through Pax610Neu: An Extension of the Pax6 Allelic Series and the Identification of Two Possible Hypomorph Alleles in the Mouse Mus musculus

2001 • 76 citations

A Single-Base Deletion in the Thrombopoietin (TPO) Gene Causes Familial Essential Thrombocythemia Through a Mechanism of More Efficient Translation of TPO mRNA

1999 • 75 citations

Sequential Partially Overlapping Gene Arrangement in the Tricistronic S1 Genome Segments of Avian Reovirus and Nelson Bay Reovirus: Implications for Translation Initiation

2002 • 75 citations

Binding of Ribosomes to Linear and Circular Forms of the 5′‐Terminal Leader Fragment of Tobacco‐Mosaic‐Virus RNA

1981 • 75 citations

Thrombopoietin Production Is Inhibited by a Translational Mechanism

1998 • 74 citations

Inefficient Reinitiation Is Responsible for Upstream Open Reading Frame–Mediated Translational Repression of the Maize R Gene

1998 • 74 citations

Attenuated APC alleles produce functional protein from internal translation initiation

2002 • 74 citations

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.

1995 • 73 citations

Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs

1994 • 73 citations

A Single-Base Deletion in the Thrombopoietin (TPO) Gene Causes Familial Essential Thrombocythemia Through a Mechanism of More Efficient Translation of TPO mRNA

1999 • 72 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control.

1994 • 72 citations

Promoter Choice Influences Alternative Splicing and Determines the Balance of Isoforms Expressed from the Mousebcl-X Gene

2001 • 72 citations

Analysis of oligonucleotide AUG start codon context in eukariotic mRNAs

2000 • 71 citations

p76MDM2 Inhibits the Ability of p90MDM2to Destabilize p53

2000 • 71 citations

Evaluation of the fidelity of initiation of translation in reticulocyte lysates from commercial sources

1990 • 71 citations

T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts

2002 • 71 citations

HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA

2000 • 70 citations

THE GENETICS OF BOVINE PAPILLOMAVIRUS TYPE 1

1988 • 69 citations

Functionality of Alternative Splice Forms of the First Enzymes Involved in Human Molybdenum Cofactor Biosynthesis

2002 • 69 citations

The Human Tryptophan Hydroxylase Gene

1995 • 69 citations

Human wig-1, a p53 target gene that encodes a growth inhibitory zinc finger protein

2001 • 68 citations

Role of mRNA Secondary Structure in Translational Repression of the Maize Transcriptional ActivatorLc ,

2001 • 68 citations

Transforming Growth Factor-β1-mediated Inhibition of the flk-1/KDR Gene Is Mediated by a 5′-Untranslated Region Palindromic GATA Site

2001 • 68 citations

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms.

1995 • 68 citations

An Alternative Promoter in the Mouse Major Histocompatibility Complex Class II I-Aβ Gene: Implications for the Origin of CpG Islands

1998 • 68 citations

Primer extension analysis of eukaryotic ribosome-mRNA complexes

1998 • 68 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Translation initiation at a downstream AUG occurs with increased efficiency when the upstream AUG is located very close to the 5' cap

1990 • 67 citations

A common polymorphism in the annexin V Kozak sequence (−1C>T) increases translation efficiency and plasma levels of annexin V, and decreases the risk of myocardial infarction in young patients

2002 • 67 citations

Expression of bacterial chitinase protein in tobacco leaves using two photosynthetic gene promoters

1988 • 66 citations

Upstream Organization of and Multiple Transcripts from the Human Folylpoly-γ-glutamate Synthetase Gene

1995 • 66 citations

Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells.

1994 • 66 citations

N-terminal RAG1 frameshift mutations in Omenn's syndrome: Internal methionine usage leads to partial V(D)J recombination activity and reveals a fundamental role in vivo for the N-terminal domains

2000 • 66 citations

Tissue-specific and Ubiquitous Promoters Direct the Expression of Alternatively Spliced Transcripts from the Calcitonin Receptor Gene

2001 • 65 citations

Picornavirus Internal Ribosome Entry Site Elements Target RNA Cleavage Events Induced by the Herpes Simplex Virus Virion Host Shutoff Protein

1999 • 64 citations

Interplay of heterogeneous transcriptional start sites and translational selection of AUGs dictate the production of mitochondrial and cytosolic/nuclear tRNA nucleotidyltransferase from the same gene in yeast.

1994 • 63 citations

Functional Organization of the Human Uncoupling Protein-2 Gene, and Juxtaposition to the Uncoupling Protein-3 Gene

1999 • 63 citations

Cell-specific translational regulation of S-adenosylmethionine decarboxylase mRNA. Influence of the structure of the 5' transcript leader on regulation by the upstream open reading frame.

1994 • 62 citations

Murine phospholipid hydroperoxide glutathione peroxidase: cDNA sequence, tissue expression, and mapping

1999 • 62 citations

N-myc translation is initiated via an internal ribosome entry segment that displays enhanced activity in neuronal cells

2001 • 62 citations

Mouse Atf5: Molecular Cloning of Two Novel mRNAs, Genomic Organization, and Odorant Sensory Neuron Localization

2002 • 61 citations

Evidence that AGAUA and CCAGA initiate translation in the same mRNA in region E3 of adenovirus

1986 • 61 citations

Characterization of two bifunctional Arabdopsis thaliana genes coding for mitochondrial and cytosolic forms of valyl‐tRNA synthetase and threonyl‐tRNA synthetase by alternative use of two in‐frame AUGs

1999 • 60 citations

Expression of the smoothelin gene is mediated by alternative promoters

2002 • 60 citations

Independent Promoters Regulate the Expression of Two Amino Terminally Distinct Forms of Latent Transforming Growth Factor-β Binding Protein-1 (LTBP-1) in a Cell Type-specific Manner

1999 • 60 citations

Mechanisms Leading to and the Consequences of Altering the Normal Distribution of ATP(CTP):tRNA Nucleotidyltransferase in Yeast

1996 • 60 citations

Analysis and mapping of a family of 3'-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99

1995 • 60 citations

Do the 5′Untranslated Domains of Human cDNAs Challenge the Rules for Initiation of Translation (or Is It Vice Versa)?

2000 • 60 citations

Translational inhibition by a human cytomegalovirus upstream open reading frame despite inefficient utilization of its AUG codon

1995 • 60 citations

Two novel beta-thalassemia mutations in the 5' and 3' noncoding regions of the beta-globin gene [see comments]

1992 • 59 citations

Translational Regulation of the JunD Messenger RNA

2002 • 59 citations

Synthesis in vitro of a seven amino acid peptide encoded in the leader RNA of Rous sarcoma virus

1986 • 58 citations

Identification of Rauscher murine leukemia virus-specific mRNAs for the synthesis of gag- and env-gene products.

1977 • 58 citations

Ribosomal Pausing and Scanning Arrest as Mechanisms of Translational Regulation from Cap-Distal Iron-Responsive Elements

1999 • 57 citations

Identification of BING-4 Cancer Antigen Translated From an Alternative Open Reading Frame of a Gene in the Extended MHC Class II Region Using Lymphocytes From a Patient With a Durable Complete Regression Following Immunotherapy

2002 • 56 citations

Polyoma virus has three late mRNA's: one for each virion protein

1978 • 56 citations

The mRNA Structure Has Potent Regulatory Effects on Type 2 Iodothyronine Deiodinase Expression

2002 • 56 citations

Translation of equine infectious anemia virus bicistronic tat-rev mRNA requires leaky ribosome scanning of the tat CTG initiation codon

1993 • 55 citations

Rice tungro bacilliform virus open reading frames II and III are translated from polycistronic pregenomic RNA by leaky scanning

1997 • 55 citations

Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames

2000 • 55 citations

Site-directed mutagenesis of adeno-associated virus type 2 structural protein initiation codons: effects on regulation of synthesis and biological activity

1994 • 54 citations

Non-AUG Initiation ofAGAMOUSmRNA Translation inArabidopsis thaliana

1999 • 54 citations

Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.

1990 • 54 citations

Expression of Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Monocistronic and Bicistronic Transcripts in Primary Effusion Lymphomas

2001 • 53 citations

Expression of Human Foamy Virus Reverse Transcriptase Involves a Spliced pol mRNA

1996 • 53 citations

Post-transcriptional Regulation of the GLI1 Oncogene by the Expression of Alternative 5′ Untranslated Regions

2001 • 52 citations

Genetic Manipulation of Arterivirus Alternative mRNA Leader-Body Junction Sites Reveals Tight Regulation of Structural Protein Expression

2000 • 52 citations

Utilization of an alternative transcription initiation site of somatic cytochrome c in the mouse produces a testis-specific cytochrome c mRNA.

1993 • 52 citations

Initiation Codon Scanthrough versus Termination Codon Readthrough Demonstrates Strong Potential for Major Histocompatibility Complex Class I–restricted Cryptic Epitope Expression

1997 • 51 citations

Genomic organization of the mouse peroxisome proliferator-activated receptor β/δ gene: alternative promoter usage and splicing yield transcripts exhibiting differential translational efficiency

2002 • 51 citations

Phenotype-Genotype Relationships in Complementation Group 3 of the Peroxisome-Biogenesis Disorders

1998 • 51 citations

In Vitro Translation of the Upstream Open Reading Frame in the Mammalian mRNA EncodingS-Adenosylmethionine Decarboxylase

2000 • 50 citations

Cloning and characterization of the gene encoding rabbit cardiac calsequestrin

1991 • 50 citations

Nucleotide sequence of the gag gene and gag-pol junction of feline leukemia virus

1984 • 50 citations

Deregulation of Translational Control of the 65-kDa Regulatory Subunit (PR65α) of Protein Phosphatase 2A Leads to Multinucleated Cells

1995 • 50 citations

The first and third uORFs in RSV leader RNA are efficiently translated: implications for translational regulation and viral RNA packaging

1995 • 49 citations

Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities

2001 • 49 citations

Mutation eliminating mitochondrial leader sequence of methylmalonyl-CoA mutase causes muto methylmalonic acidemia.

1990 • 49 citations

Complex organisation of the 5′-end of the human glycine tRNA synthetase gene

1998 • 49 citations

Analysis of Capsid Formation of Human Polyomavirus JC (Tokyo-1 Strain) by a Eukaryotic Expression System: Splicing of Late RNAs, Translation and Nuclear Transport of Major Capsid Protein VP1, and Capsid Assembly

2000 • 48 citations

Migration of 40 S ribosomal subunits on messenger RNA when initiation is perturbed by lowering magnesium or adding drugs.

1979 • 48 citations

The Two Forms of Karyogamy Transcription Factor Kar4p Are Regulated by Differential Initiation of Transcription, Translation, and Protein Turnover

1999 • 48 citations

The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation

1995 • 47 citations

A translation-attenuating intraleader open reading frame is selected on coronavirus mRNAs during persistent infection.

1993 • 47 citations

The Human Cytomegalovirus UL35 Gene Encodes Two Proteins with Different Functions

2002 • 47 citations

Bovine coronavirus I protein synthesis follows ribosomal scanning on the bicistronic N mRNA

1997 • 46 citations

Uroporphyrinogen III Synthase

2000 • 46 citations

Analysis of ribosome binding sites from the s1 message of reovirus

1982 • 46 citations

Negative and Translation Termination-Dependent Positive Control of FLI-1 Protein Synthesis by Conserved Overlapping 5′ Upstream Open Reading Frames in Fli-1 mRNA

2000 • 46 citations

Structural and Functional Genomics of the CPT1B Gene for Muscle-type Carnitine Palmitoyltransferase I in Mammals

2002 • 46 citations

Inhibition of Corticotropin Releasing Hormone Type-1 Receptor Translation by an Upstream AUG Triplet in the 5′ Untranslated Region

2001 • 46 citations

Multiple Murine Double Minute Gene 2 (MDM2) Proteins Are Induced by Ultraviolet Light

1999 • 46 citations

Identification of a Novel RNA Splicing Pattern as a Basis of Restricted Cell Tropism of Erythrovirus B19

2000 • 46 citations

Identification of a sequence in the unique 5' open reading frame of the gene encoding glycosylated Gag which influences the incubation period of neurodegenerative disease induced by a murine retrovirus

1994 • 45 citations

Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae.

1994 • 45 citations

Posttranscriptional mRNA processing as a mechanism for regulation of human A1 adenosine receptor expression.

1994 • 45 citations

Transcription of feline calicivirus RNA

1990 • 44 citations

A Common C→T Polymorphism at nt 46 in the Promoter Region of Coagulation Factor XII is Associated With Decreased Factor XII Activity

2001 • 44 citations

Specific Cleavage of Hepatitis C Virus RNA Genome by Human RNase P

2002 • 44 citations

Translation of the Second Gene of Peanut Clump Virus RNA 2 Occurs by Leaky Scanning in Vitro

1995 • 44 citations

Amino-Terminal Extension Generated from an Upstream AUG Codon Increases the Efficiency of Mitochondrial Import of Yeast N²,N²-Dimethylguanosine-Specific tRNA Methyltransferases

1989 • 43 citations

The three dominant female-sterile mutations of the Drosophila ovo gene are point mutations that create new translation-initiator AUG codons

1996 • 43 citations

Translational regulation of complement protein C2 expression by differential utilization of the 5'-untranslated region of mRNA.

1990 • 43 citations

Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease

1999 • 42 citations

Translational regulation of hepatitis B virus polymerase gene by termination-reinitiation of an upstream minicistron in a length-dependent manner.

1998 • 42 citations

Biosynthesis of Osteogenic Growth Peptide via Alternative Translational Initiation at AUG85 of Histone H4 mRNA

1999 • 42 citations

Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation.

1990 • 42 citations

Subgenomic RNAs mediate expression of cistrons located internally on the genomic RNA of tobacco necrosis virus strain A

1992 • 41 citations

A novel missense mutation in the amino-terminal domain of the human androgen receptor gene in a family with partial androgen insensitivity syndrome causes reduced efficiency of protein translation.

1996 • 41 citations

Characterization of the Murine Hyaluronidase Gene Region Reveals Complex Organization and Cotranscription ofHyal1 with Downstream Genes, Fus2 andHyal3

2002 • 41 citations

Expression and function of CCAAT/enhancer binding proteinβ (C/EBPβ) LAP and LIP isoforms in mouse mammary gland, tumors and cultured mammary epithelial cells

2001 • 41 citations

Identification of eight novel 5′-exons in cerebral capillary malformation gene-1 (CCM1) encoding KRIT1

2001 • 41 citations

Mass Spectrometric Analysis of the N Terminus of Translational Initiation Factor eIF4G-1 Reveals Novel Isoforms

2002 • 40 citations

RNA Polymerase I-Promoted HIS4 Expression Yields Uncapped, Polyadenylated mRNA That Is Unstable and Inefficiently Translated in Saccharomyces cerevisiae

1998 • 40 citations

The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes

2000 • 39 citations

Systemic movement of an RNA plant virus determined by a point substitution in a 5' leader sequence.

1990 • 39 citations

Characterization of the infections of permissive and nonpermissive cells by host range mutants of vesicular stomatitis virus defective in RNA methylation

1984 • 39 citations

Characterization of an Internal Ribosomal Entry Segment in the 5′ Leader of Murine Leukemia Virus env RNA

2000 • 39 citations

Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: Common types of shorter transcripts are true alternative splice variants

1998 • 38 citations

Generation of Stable mRNA Fragments and Translation of N-Truncated Proteins Induced by Antisense Oligodeoxynucleotides

2001 • 38 citations

The increased level of β1,4-galactosyltransferase required for lactose biosynthesis is achieved in part by translational control

1998 • 38 citations

Two distinct protein isoforms are encoded by ntk, a csk-related tyrosine protein kinase gene.

1994 • 38 citations

The Promoters for Human and Monkey Poliovirus Receptors

1997 • 37 citations

Correlation between sequence conservation of the 5′ untranslated region and codon usage bias in Mus musculus genes

2001 • 37 citations

Starved Saccharomyces cerevisiae Cells Have the Capacity to Support Internal Initiation of Translation

1999 • 37 citations

Cloning and Origin of the Two Forms of Chicken Vitamin D Receptor

1997 • 37 citations

Structure of the PCCA Gene and Distribution of Mutations Causing Propionic Acidemia

2001 • 37 citations

Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein

2000 • 36 citations

Mechanisms of Loss of Foreign Gene Expression in Recombinant Vesicular Stomatitis Viruses

2001 • 36 citations

An extended RNA/RNA duplex structure within the coding region of mRNA does not block translational elongation

1988 • 35 citations

Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms

1995 • 35 citations

Minimal truncation of the c-myb gene product in rapid-onset B-cell lymphoma

1997 • 35 citations

Production of Three Distinct mRNAs of 150 kDa Oxygen-Regulated Protein (ORP150) by Alternative Promoters: Preferential Induction of One Species under Stress Condition

2000 • 34 citations

Both Codon Context and Leader Length Contribute to Efficient Expression of Two Overlapping Open Reading Frames of a Cucumber Necrosis Virus Bifunctional Subgenomic mRNA

1996 • 34 citations

Analysis of the CC chemokine receptor 3 gene reveals a complex 5′ exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements

2000 • 34 citations

Structure of the GM2A Gene: Identification of an Exon 2 Nonsense Mutation and a Naturally Occurring Transcript with an In-Frame Deletion of Exon 2

1999 • 34 citations

A 6700 MW membrane protein is encoded by region E3 of adenovirus type 2

1990 • 33 citations

Rhmod Syndrome: A Family Study of the Translation-Initiator Mutation in the Rh50 Glycoprotein Gene

1999 • 33 citations

Mapping and Expression of Southern Bean Mosaic Virus Genomic and Subgenomic RNAs

1997 • 32 citations

Identification of the Subgenomic mRNAs That Encode 6-kDa Movement Protein and Hsp70 Homolog of Beet Yellows Virus

2002 • 32 citations

Caenorhabditis elegans mRNAs that encode a protein similar to ADARs derive from an operon containing six genes

1999 • 32 citations

Mapping of the Polycistronic RNAs of Tomato Leaf Curl Geminivirus

1993 • 31 citations

Mechanisms of synthesis of virion proteins from the functionally bigenic late mRNAs of simian virus 40

1988 • 31 citations

Identification and Functional Analysis of the Turnip Yellow Mosaic Tymovirus Subgenomic Promoter

2000 • 31 citations

A Novel Subgenomic Murine Leukemia Virus RNA Transcript Results from Alternative Splicing

2000 • 31 citations

Hepatocyte-nuclear factor 3 beta gene transcripts generate protein isoforms with different transactivation properties on the glucagon gene.

1995 • 31 citations

Identification of a New Form of AQP4 mRNA That Is Developmentally Expressed in Mouse Brain

2000 • 31 citations

Truncated Forms of the Dual Function Human ASCT2 Neutral Amino Acid Transporter/Retroviral Receptor Are Translationally Initiated at Multiple Alternative CUG and GUG Codons

2001 • 30 citations

RNA Targets of the Fragile X Protein

2001 • 30 citations

Omenn症候群におけるN末端RAG1フレームシフト突然変異 内部メチオニン使用が部分的なV(D)J組換え活性を導き,アミノ末端ドメインのin vivoにおける基本的役割が明らかになっている

2000 • 30 citations

Poliovirus Neurovirulence Correlates with the Presence of a Cryptic AUG Upstream of the Initiator Codon

1996 • 30 citations

The Position Dependence of Translational Regulation via RNA-RNA and RNA-Protein Interactions in the 5′-Untranslated Region of Eukaryotic mRNA Is a Function of the Thermodynamic Competence of 40 S Ribosomes in Translational Initiation

1997 • 30 citations

Abundant Early Expression of gpUL4 from a Human Cytomegalovirus Mutant Lacking a Repressive Upstream Open Reading Frame

2001 • 30 citations

Ataxia caused by mutations in the alpha -tocopherol transfer protein gene

2000 • 29 citations

Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene

1991 • 29 citations

The 105-kDa Polyprotein of Southern Bean Mosaic Virus Is Translated by Scanning Ribosomes

1998 • 29 citations

Translation initiation and assembly of peripherin in cultured cells.

1995 • 29 citations

Downstream Ribosomal Entry for Translation of Coronavirus TGEV Gene 3b

2000 • 29 citations

Amino-terminal extension generated from an upstream AUG codon increases the efficiency of mitochondrial import of yeast N2,N2-dimethylguanosine-specific tRNA methyltransferases.

1989 • 28 citations

A testis-specific promoter in the rat vasopressin gene.

1994 • 28 citations

Elements in the murine c-mos messenger RNA 5'-untranslated region repress translation of downstream coding sequences.

1996 • 28 citations

Ubiquitin-activating Enzyme (E1) Isoforms in Lens Epithelial Cells: Origin of Translation, E2 Specificity and Cellular Localization Determined with Novel Site-specific Antibodies

2001 • 28 citations

The two subunits of human molybdopterin synthase: Evidence for a bicistronic messenger RNA with overlapping reading frames

1999 • 27 citations

Rejection antigen peptides on BALB/c RL male 1 leukemia recognized by cytotoxic T lymphocytes: derivation from the normally untranslated 5' region of the c-akt proto-oncogene activated by long terminal repeat.

1995 • 27 citations

Spliced and Prematurely Polyadenylated Jaagsiekte Sheep Retrovirus-Specific RNAs from Infected or Transfected Cells

2002 • 27 citations

A novel deletion of the <scp>l</scp>‐ferritin iron‐responsive element responsible for severe hereditary hyperferritinaemia–cataract syndrome

2002 • 27 citations

Multiple elements in the 5' untranslated region down-regulate c-sis messenger RNA translation.

1995 • 26 citations

Novel short transcripts of hepatitis B virus X gene derived from intragenic promoter.

1994 • 26 citations

ABCD1 translation–initiator mutation demonstrates genotype–phenotype correlation for AMN

2001 • 26 citations

Tissue-specific initiation of murine complement factor B mRNA transcription.

1989 • 26 citations

Translational Control of the Xenopus laevisConnexin-41 5′-Untranslated Region by Three Upstream Open Reading Frames

2000 • 26 citations

Nucleotide sequence and expression of the small (S) RNA segment of Maguari bunyavirus

1989 • 26 citations

The Human Achaete Scute Homolog 2 Gene Contains Two Promotors, Generating Overlapping Transcripts and Encoding Two Proteins with Different Nuclear Localization

2001 • 26 citations

Alternative transcriptional initiation as a novel mechanism for regulating expression of a baculovirus trans activator

1993 • 25 citations

Genomic Organization of HumanMXI1, a Putative Tumor Suppressor Gene

1996 • 25 citations

The 5' Untranslated Regions of the Rat A_2A Adenosine Receptor Gene Function as Negative Translational Regulators

1999 • 25 citations

The hormone-sensitive lipase gene is transcribed from at least five alternative first exons in mouse adipose tissue

2000 • 25 citations

Normal developing rat brain expresses a platelet-derived growth factor B chain (c-sis) mRNA truncated at the 5′ end

1998 • 25 citations

Molecular Cloning and Characterization of the Mouse Peroxiredoxin V Gene

2000 • 25 citations

Intron-exon structure of the MET gene and cloning of an alternatively-spliced Met isoform reveals frequent exon-skipping of a single large internal exon

1998 • 25 citations

The Baculovirus Transcriptional Transactivator ie0 Produces Multiple Products by Internal Initiation of Translation

2001 • 24 citations

Translational initiation competence, ‘leaky scanning’ and translational reinitiation in areA mRNA of Aspergillus nidulans

1996 • 24 citations

An ERCC1 splicing variant involving the 5′-UTR of the mRNA may have a transcriptional modulatory function

2001 • 24 citations

Evidence for translational regulation of the imprinted Snurf-Snrpn locus in mice

2002 • 23 citations

Mutation creates an open reading frame within the 5' untranslated region of macaque erythrocyte carbonic anhydrase (CA) I mRNA that suppresses CA I expression and supports the scanning model for translation.

1992 • 23 citations

Evidence for the existence of a coat protein messenger RNA associated with the top component of each of three tymoviruses

1978 • 22 citations

Molecular Basis for the Dual Mitochondrial and Cytosolic Localization of Alanine:Glyoxylate Aminotransferase in Amphibian Liver Cells

2002 • 22 citations

A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins.

1993 • 22 citations

Preferential ribosomal scanning is involved in the differential synthesis of the hepatitis B viral surface antigens from subgenomic transcripts

1992 • 22 citations

Continuous and Discontinuous Ribosome Scanning on the Cauliflower Mosaic Virus 35 S RNA Leader Is Controlled by Short Open Reading Frames

2000 • 21 citations

Expression Patterns of the Multiple Transcripts from the Folylpolyglutamate Synthetase Gene in Human Leukemias and Normal Differentiated Tissues

2000 • 21 citations

The GlycosylatedgagProtein of MuLV Is a Determinant of Neuroinvasiveness: Analysis of Second Site Revertants of a Mutant MuLV Lacking Expression of This Protein

1996 • 20 citations

Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein ΔBRCA1(17aa)

2000 • 20 citations

Cell type-dependent and -independent control of HER-2/neu translation

1999 • 19 citations

Multiple 5′-untranslated exons in the nuclear respiratory factor 1 gene span 47 kb and contribute to transcript heterogeneity and translational efficiency

1999 • 19 citations

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene.

1994 • 19 citations

Translation of p15.5INK4B, an N-terminally extended and fully active form of p15INK4B, is initiated from an upstream GUG codon

2000 • 19 citations

Restriction of Fusion Protein mRNA as a Mechanism of Measles Virus Persistence

1994 • 19 citations

The short 5' untranslated region of the betaA3/A1-crystallin mRNA is responsible for leaky ribosomal scanning.

1999 • 18 citations

Ribosomal scanning on the highly structured insulin-like growth factor II-leader 1

2002 • 18 citations

Inefficient Reinitiation Is Responsible for Upstream Open Reading Frame-Mediated Translational Repression of the Maize R Gene

1998 • 18 citations

Identification of a Noncanonical Signal for Transcription of a Novel Subgenomic mRNA of Mouse Hepatitis Virus: Implication for the Mechanism of Coronavirus RNA Transcription

2000 • 17 citations

Identification of the Serum-Responsive Transcription Initiation Site of the Zinc Finger Gene Krox-20

1990 • 17 citations

The two proteins encoded by the cottontail rabbit papillomavirus E6 open reading frame differ with respect to localization and phosphorylation

1988 • 17 citations

Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-β1 transcripts and their effect on translational efficiency

1998 • 17 citations

Cancer‐associated alternative usage of multiple promoters of human GalCer sulfotransferase gene

2000 • 16 citations

Differential translational initiation of lbp mRNA is caused by a 5′ upstream open reading frame¹

1997 • 16 citations

Apobec-1 transcription in rat colon cancer: decreased apobec-1 protein production through alterations in polysome distribution and mRNA translation associated with upstream AUGs

2002 • 15 citations

Splicing in Adenovirus and Other Animal Viruses

1985 • 15 citations

Mouse Mammary Tumor Virus Superantigen Expression in B Cells Is Regulated by a Central Enhancer within thepolGene

1998 • 15 citations

Translational stop codons in the precore sequence of hepatitis B virus pre-C RNA allow translation reinitiation at downstream AUGs

1996 • 14 citations

Novel products of the HUD, HUC, NNP‐1 and α‐internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library

2002 • 14 citations

Unconventional mRNA processing in the expression of two calcineurin B isoforms in Dictyostelium

2001 • 14 citations

Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat

2001 • 14 citations

The 5′ UTR of Protein Kinase C ϵ Confers Translational Regulation in Vitro and in Vivo

2001 • 14 citations

The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo

1997 • 14 citations

Translational Control of Mammalian Serine Hydroxymethyltransferase Expression

1995 • 13 citations

The 5′-untranslated region of the mouse glial cell line-derived neurotrophic factor gene regulates expression at both the transcriptional and translational levels

2001 • 13 citations

Identification of a brain-specific protein kinase Cζ pseudogene (ΨPKCζ) transcript

1995 • 12 citations

Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.

1992 • 12 citations

Genomic structure of Unp, a murine gene encoding a ubiquitin-specific protease

1998 • 11 citations

Identification of the serum-responsive transcription initiation site of the zinc finger gene Krox-20.

1990 • 11 citations

Characterization of an upstream open reading frame in the 5′ untranslated region of PR-39, a cathelicidin antimicrobial peptide

2002 • 11 citations

COT Kinase Proto-oncogene Expression in T Cells

2000 • 11 citations

Lost in translation

2002 • 9 citations

An altered ribosomal protein in an edeine-resistant mutant of Saccharomyces cerevisiae

1986 • 7 citations