Expression of Murine IL-12 Is Regulated by Translational Control of the p35 Subunit

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

Rapid production of full-length cDNAs from rare transcripts: amplification using a single gene-specific oligonucleotide primer.

1988 • 4,669 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 • 1,989 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

1991 • 861 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Interleukin‐12 is produced by dendritic cells and mediates T helper 1 development as well as interferon‐γ production by T helper 1 cells

1996 • 676 citations

The interleukin 12 p40 gene promoter is primed by interferon gamma in monocytic cells.

1996 • 663 citations

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

1991 • 593 citations

Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

1995 • 495 citations

Interleukin‐12 is required for interferon‐γ production and lethality in lipopolysaccharide‐induced shock in mice

1995 • 491 citations

Cloning and expression of murine IL-12.

1992 • 474 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

Molecular Mechanisms of the Induction of IL-12 and Its Inhibition by IL-10

1998 • 397 citations

Multistage Regulation of Th1-Type Immune Responses by the Transcription Factor IRF-1

1997 • 354 citations

Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes

1995 • 341 citations

Multiple Control Elements Mediate Activation of the Murine and Human Interleukin 12 p40 Promoters: Evidence of Functional Synergy between C/EBP and Rel Proteins

1997 • 310 citations

Regulation of bioactive IL-12 production in lipopolysaccharide-stimulated human monocytes is determined by the expression of the p35 subunit.

1996 • 306 citations

Recurrent Mutations in a Single Exon Encoding the Evolutionarily Conserved Olfactomedin-Homology Domain of TIGR in Familial Open-Angle Glaucoma

1997 • 282 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

Interferon Consensus Sequence Binding Protein–deficient Mice Display Impaired Resistance to Intracellular Infection Due to a Primary Defect in Interleukin 12 p40 Induction

1997 • 220 citations

Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

1996 • 218 citations

Substance P-induced IL-12 production by murine macrophages.

1997 • 166 citations

Regulation of IL-18 (IFN-gamma-inducing factor) gene expression.

1997 • 162 citations

Identification and Characterization of a Novel Ets-2-related Nuclear Complex Implicated in the Activation of the Human Interleukin-12 p40 Gene Promoter

1997 • 143 citations

Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor

1997 • 136 citations

Lipopolysaccharide-induced IL-12 expression in the central nervous system and cultured astrocytes and microglia.

1997 • 112 citations

Molecular cloning and characterization of murine IL-12 genes.

1996 • 93 citations

Structure and chromosomal location of the mouse interleukin‐12 p35 and p40 subunit genes

1996 • 78 citations

Differential expression of mRNA encoding interleukin‐12 p35 and p40 subunits in situ

1994 • 77 citations

Long-range transcriptional regulation of cytokine gene expression

1998 • 71 citations

Intracellular Salmonella dublin induces substantial secretion of the 40-kilodalton subunit of interleukin-12 (IL-12) but minimal secretion of IL-12 as a 70-kilodalton protein in murine macrophages

1997 • 67 citations

Differential production of interleukin-12 mRNA by murine macrophages in response to viable or killed Salmonella spp

1996 • 63 citations

IL-12 increases CD80 expression and the stimulatory capacity of bone marrow-derived dendritic cells

1998 • 61 citations

Regulation of the IL-12 receptor β2 subunit by soluble antigen and IL-12in vivo

1998 • 32 citations

In vivofootprinting of the human IL-2 gene reveals a nuclear factor bound to the transcription start site in T cells

1993 • 31 citations

The Proinflammatory Cytokine Interleukin-12 Occurs as a Cell Membrane-Bound Form on Macrophages

1996 • 29 citations

Translational regulation of murine complement factor B alternative transcripts by upstream AUG codons.

1995 • 19 citations