RNA Polymerase I-Promoted HIS4 Expression Yields Uncapped, Polyadenylated mRNA That Is Unstable and Inefficiently Translated in Saccharomyces cerevisiae

Methods in yeast genetics

1979 • 7,824 citations

The scanning model for translation: an update.

1989 • 3,525 citations

A positive selection for mutants lacking orotidine-5′-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance

1984 • 2,401 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G.

1996 • 679 citations

Degradation of mRNA in eukaryotes

1995 • 648 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript.

1994 • 511 citations

A nuclear cap binding protein complex involved in pre-mRNA splicing

1994 • 506 citations

[24] Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: Thermal race

1993 • 501 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

How the messenger got its tail: addition of poly(A) in the nucleus

1990 • 390 citations

Yeast cells lacking 5'-->3' exoribonuclease 1 contain mRNA species that are poly(A) deficient and partially lack the 5' cap structure.

1993 • 378 citations

A common function for mRNA 5' and 3' ends in translation initiation in yeast.

1995 • 374 citations

A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.

1988 • 370 citations

In vivo transcriptional pausing and cap formation on three Drosophila heat shock genes.

1993 • 361 citations

Poly(A), poly(A) binding protein and the regulation of mRNA stability

1989 • 355 citations

Turnover Mechanisms of the Stable Yeast PGK1 mRNA

1995 • 341 citations

How RNA polymerase II terminates transcription in higher eukaryotes

1989 • 301 citations

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

1988 • 283 citations

Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast.

1995 • 278 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

The relationship between the "TATA" sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae.

1985 • 265 citations

The nucleotide sequence of the HIS4 region of yeast

1982 • 233 citations

Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding.

1992 • 215 citations

GTP hydrolysis controls stringent selection of the AUG start codon during translation initiation inSaccharomyces cerevisiae

1997 • 209 citations

Translation Initiation and Ribosomal Biogenesis: Involvement of a Putative rRNA Helicase and RPL46

1990 • 204 citations

Yeast Cells Lacking 5'→3' Exoribonuclease 1 Contain mRNA Species That are Poly(A) Deficient and Partially Lack the 5' Cap Structure

1993 • 190 citations

Synthesis of large rRNAs by RNA polymerase II in mutants of Saccharomyces cerevisiae defective in RNA polymerase I.

1991 • 174 citations

Possible Involvement of poly(A) in protein synthesks

1983 • 160 citations

An RNA polymerase I enhancer in Saccharomyces cerevisiae.

1986 • 151 citations

Characterization of cis-Acting Sequences and Decay Intermediates Involved in Nonsense-Mediated mRNA Turnover

1995 • 146 citations

Mutational Analysis of the HIS4 Translational Initiator Region in Saccharomyces cerevisiae

1988 • 142 citations

Human ribosomal RNA gene: nucleotide sequence of the transcription initiation region and comparison of three mammalian genes.

1982 • 139 citations

Transcription of herpes simplex virus tk sequences under the control of wild-type and mutant human RNA polymerase I promoters.

1985 • 138 citations

RNA Processing Generates the Mature 3′ End of Yeast CYC1 Messenger RNA in Vitro

1988 • 129 citations

Circular dichroism studies of an oligodeoxyribonucleotide containing a hairpin loop made of a hexaethylene glycol chain: conformation and stability

1990 • 121 citations

Genetic selection for mutations that reduce or abolish ribosomal recognition of the HIS4 translational initiator region.

1988 • 120 citations

The REB1 site is an essential component of a terminator for RNA polymerase I in Saccharomyces cerevisiae.

1993 • 109 citations

Nucleotide sequence of the initiation site for ribosomal RNA transcription in Drosophila melanogaster: comparison of genes with and without insertions.

1981 • 96 citations

Cloning and characterization of DST2, the gene for DNA strand transfer protein beta from Saccharomyces cerevisiae.

1991 • 95 citations

A Freeze-Frame View of Eukaryotic Transcription During Elongation and Capping of Nascent mRNA

1992 • 89 citations

Regulation and Intracellular Localization of Saccharomyces cerevisiae Strand Exchange Protein 1 (Sep1/Xrn1/Kem1), a Multifunctional Exonuclease

1995 • 88 citations

A mutation in the tRNA nucleotidyltransferase gene promotes stabilization of mRNAs in Saccharomyces cerevisiae.

1992 • 87 citations

Suppressor analysis of temperature-sensitive mutations of the largest subunit of RNA polymerase I in Saccharomyces cerevisiae: a suppressor gene encodes the second-largest subunit of RNA polymerase I.

1991 • 85 citations

A Polymerase Switch in the Synthesis of rRNA in Saccharomyces cerevisiae

1995 • 79 citations

The 5′ terminus of the precursor ribosomal RNA of Saccharomyces cerevisiae

1980 • 75 citations

The structure of the yeast ribosomal RNA genes. 2. The nucleotide sequence of the initiation site for ribosomal RNA transription

1980 • 74 citations

A rabbit beta-globin polyadenylation signal directs efficient termination of transcription of polyomavirus DNA.

1988 • 70 citations

Conditional mutants of the yeast mRNA capping enzyme show that the cap enhances, but is not required for, mRNA splicing.

1996 • 69 citations

Poliovirus Translation

1990 • 66 citations

Identification of pre-mRNA polyadenylation sites in Saccharomyces cerevisiae.

1992 • 64 citations

Functional mRNA Can Be Generated by RNA Polymerase III

1995 • 63 citations

An RNA Polymerase I Enhancer in Saccharomyces cerevisiae

1986 • 62 citations

Efficient transcription of a protein-coding gene from the RNA polymerase I promoter in transfected cells.

1985 • 58 citations

Transcription of Herpes Simplex Virus tk Sequences Under the Control of Wild-Type and Mutant Human RNA Polymerase I Promoters

1985 • 57 citations

Translation of c-myc mRNA is required for its post-transcriptional regulation during myogenesis.

1990 • 54 citations

Genetic Selection for Mutations That Reduce or Abolish Ribosomal Recognition of the HIS4 Translational Initiator Region

1988 • 46 citations

Antibody-nucleic acid complexes. Immunospecific retention of globin mRNA with antibodies specific for 7-methylguanosine

1982 • 42 citations

Transcription initiation by RNA polymerase II is inhibited by S-adenosylhomocysteine.

1982 • 41 citations

Suppressor Analysis of Temperature-Sensitive Mutations of the Largest Subunit of RNA Polymerase I in Saccharomyces cerevisiae: a Suppressor Gene Encodes the Second-Largest Subunit of RNA Polymerase I

1991 • 33 citations

A Mutation in the tRNA Nucleotidyltransferase Gene Promotes Stabilization of mRNAs in Saccharomyces cerevisiae

1992 • 29 citations

Cloning and Characterization of DST2, the Gene for DNA Strand Transfer Protein β from Saccharomyces cerevisiae

1991 • 24 citations

Rapid Amplification of Complementary DNA Ends for Generation of Full-Length Complementary DNAs: Thermal RACE

1995 • 23 citations

Identification of Pre-mRNA Polyadenylation Sites in Saccharomyces cerevisiae

1992 • 22 citations

<scp>III</scp>. Yeast sequencing reports. The complete sequence of a 11,953 bp fragment from C1G on chromosome III encompasses four new open reading frames

1991 • 11 citations