Cloning and Characterization of Liver-specific Isoform of Chk1 Gene from Rat

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

The DNA damage response: putting checkpoints in perspective

2000 • 3,147 citations

CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors

1997 • 2,201 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

Mitotic and G ₂ Checkpoint Control: Regulation of 14-3-3 Protein Binding by Phosphorylation of Cdc25C on Serine-216

1997 • 1,332 citations

Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

1997 • 1,285 citations

ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

2001 • 1,036 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle

1995 • 918 citations

Rapid Destruction of Human Cdc25A in Response to DNA Damage

2000 • 768 citations

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

2000 • 620 citations

Cdc25 Mitotic Inducer Targeted by Chk1 DNA Damage Checkpoint Kinase

1997 • 541 citations

Aberrant cell cycle checkpoint function and early embryonic death in Chk1^−/− mice

2000 • 466 citations

Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

1993 • 464 citations

Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation

1997 • 392 citations

The G2-phase DNA-damage checkpoint

2000 • 365 citations

Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control

1996 • 338 citations

Replication checkpoint requires phosphorylation of the phosphatase Cdc25 by Cds1 or Chk1

1998 • 338 citations

Positive Regulation of Wee1 by Chk1 and 14-3-3 Proteins

2001 • 277 citations

Two distinct factors interact with the promoter regions of several liver-specific genes.

1988 • 226 citations

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK

1999 • 221 citations

Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways

2000 • 220 citations

Regulating the onset of mitosis

1999 • 195 citations

Implications for Chk1 Regulation: The 1.7 Å Crystal Structure of Human Cell Cycle Checkpoint Kinase Chk1

2000 • 192 citations

Cell cycle-dependent and ATM-independent expression of human Chk1 kinase

1999 • 150 citations

Proteins binding to the liver-specific pyruvate kinase gene promoter

1989 • 145 citations

Evidence for a complex regulatory array in the first intron of the human adenosine deaminase gene.

1989 • 124 citations

Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine

2001 • 120 citations

Checkpoints controlling mitosis

2000 • 103 citations

Evidence for a terminal differentiation process in the rat liver

1995 • 91 citations

DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival.

1997 • 89 citations

Replication checkpoint: Preventing mitotic catastrophe

2001 • 78 citations

The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes

1991 • 68 citations

DNA damage: Chk1 and Cdc25, more than meets the eye

2001 • 61 citations

Changes in Ploidy Distributions in Human Liver Carcinogenesis

1988 • 52 citations

Hepatocyte Polyploidy and Metabolism/Life-history Traits: Hypotheses Testing

1994 • 46 citations

Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350

2000 • 23 citations

Variations of hepatic antioxidant systems and DNA ploidy in rats aged 2 to 8 months

1996 • 21 citations

Human–mouse comparative sequence analysis of the NEMO gene reveals an alternative promoter within the neighboring G6PD gene

2001 • 21 citations

“Isogaba Maware”: quality control of genome DNA by checkpoints

1998 • 14 citations

Growth-related alterations during liver carcinogenesis: effect of promoters.

1990 • 9 citations