Molecular biology of calcium channels

Multiple types of neuronal calcium channels and their selective modulation

1988 • 1,399 citations

Primary structure of the receptor for calcium channel blockers from skeletal muscle

1987 • 1,359 citations

Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells

1994 • 998 citations

Roles of N-Type and Q-Type Ca ²⁺ Channels in Supporting Hippocampal Synaptic Transmission

1994 • 964 citations

Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

1989 • 922 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

1992 • 877 citations

Primary structure and functional expression from complementary DNA of a brain calcium channel

1991 • 871 citations

Restoration of excitation—contraction coupling and slow calcium current in dysgenic muscle by dihydropyridine receptor complementary DNA

1988 • 803 citations

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

1994 • 659 citations

Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons

1993 • 635 citations

Molecular determinants of Ca2+ selectivity and ion permeation in L-type Ca2+ channels

1993 • 614 citations

Regions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction coupling

1990 • 606 citations

Sequence and Expression of mRNAs Encoding the α ₁ and α ₂ Subunits of a DHP-Sensitive Calcium Channel

1988 • 579 citations

Structure and Functional Expression of a Member of the Low Voltage-Activated Calcium Channel Family

1993 • 572 citations

The Roles of the Subunits in the Function of the Calcium Channel

1991 • 550 citations

Molecular model of the action potential sodium channel.

1986 • 525 citations

Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype

1992 • 499 citations

Structure and Functional Expression of an ω-Conotoxin-Sensitive Human N-Type Calcium Channel

1992 • 496 citations

Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits

1993 • 431 citations

Ca2+ channels in rat central and peripheral neurons: High-threshold current resistant to dihydropyridine blockers and ω-conotoxin

1991 • 423 citations

Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel.

1992 • 416 citations

Purified dihydropyridine-binding site from skeletal muscle t-tubules is a functional calcium channel

1986 • 405 citations

Primary Structure of the β Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1989 • 371 citations

Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.

1994 • 366 citations

Distinct calcium channels are generated by alternative splicing and are differentially expressed in the mammalian CNS

1991 • 366 citations

Calcium channel beta subunit heterogeneity: functional expression of cloned cDNA from heart, aorta and brain.

1992 • 339 citations

Distribution and functional significance of the P-type, voltage-dependent Ca2+ channels in the mammalian central nervous system

1992 • 335 citations

Molecular cloning of the alpha-1 subunit of an omega-conotoxin-sensitive calcium channel.

1992 • 317 citations

Primary structure of a calcium channel that is highly expressed in the rat cerebellum.

1991 • 309 citations

Induction of calcium currents by the expression of the α1-subunit of the dihydropyridine receptor from skeletal muscle

1989 • 297 citations

Subunits of purified calcium channels. Alpha 2 and delta are encoded by the same gene.

1990 • 288 citations

Normalization of current kinetics by interaction between the α1and β subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel

1991 • 286 citations

Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.

1994 • 278 citations

The stimulatory G protein of adenylyl cyclase, Gs, also stimulates dihydropyridine-sensitive Ca2+ channels. Evidence for direct regulation independent of phosphorylation by cAMP-dependent protein kinase or stimulation by a dihydropyridine agonist.

1988 • 273 citations

Primary Structure of the γ Subunit of the DHP-Sensitive Calcium Channel from Skeletal Muscle

1990 • 263 citations

Functional expression of a rapidly inactivating neuronal calcium channel

1993 • 262 citations

Structural characterization of the dihydropyridine-sensitive calcium channel alpha 2-subunit and the associated delta peptides.

1991 • 260 citations

Subunit Identification and Reconstitution of the N-Type Ca ²⁺ Channel Complex Purified from Brain

1993 • 255 citations

Ca2+ channel regulation by a conserved β subunit domain

1994 • 252 citations

Potentiation by the β Subunit of the Ratio of the Ionic Current to the Charge Movement in the Cardiac Calcium Channel

1993 • 250 citations

Primary structure and functional expression of a high voltage activated calcium channel from rabbit lung

1990 • 240 citations

Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits.

1987 • 231 citations

Primary structure and functional expression of the ω-conotoxin-sensitive N-type calcium channel from rabbit brain

1993 • 230 citations

Cloning and expression of a neuronal calcium channel beta subunit

1993 • 228 citations

cDNA cloning of a dihydropyridine-sensitive calcium channel from rat aorta. Evidence for the existence of alternatively spliced forms.

1990 • 219 citations

Heterologous regulation of the cardiac Ca2+ channel alpha 1 subunit by skeletal muscle beta and gamma subunits. Implications for the structure of cardiac L-type Ca2+ channels.

1991 • 218 citations

Molecular determinants of voltage-dependent inactivation in calcium channels

1994 • 217 citations

Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes

1990 • 217 citations

Purification of the N-type calcium channel associated with syntaxin and synaptotagmin. A complex implicated in synaptic vesicle exocytosis.

1994 • 210 citations

Cloning and expression of a third calcium channel beta subunit.

1993 • 197 citations

Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.

1992 • 195 citations

Molecular cloning of multiple subtypes of a novel rat brain isoform of the α1 subunit of the voltage-dependent calcium channel

1991 • 194 citations

The amino terminus of a calcium channel β subunitsets rates of channel inactivation independently of the subunit's effect on activation

1994 • 191 citations

Cloning and tissue‐specific expression of the brain calcium channel β‐subunit

1991 • 186 citations

Molecular localization of ion selectivity sites within the pore of a human L-type cardiac calcium channel

1993 • 173 citations

Differential phosphorylation of two size forms of the neuronal class C L-type calcium channel alpha 1 subunit.

1993 • 168 citations

Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.

1994 • 168 citations

Localization of the gene encoding the α₂/δ-subunits of the L-type voltage-dependent calcium channel to chromosome 7q and analysis of the segregation of flanking markers in malignant hyperthermia susceptible families

1994 • 164 citations

Functional properties of a neuronal class C L-type calcium channel

1993 • 163 citations

Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor.

1987 • 161 citations

Subunits of purified calcium channels: a 212-kDa form of alpha 1 and partial amino acid sequence of a phosphorylation site of an independent beta subunit.

1989 • 157 citations

Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations.

1987 • 150 citations

Structural determinants of ion selectivity in brain calcium channel

1993 • 147 citations

Characterization of the two size forms of the alpha 1 subunit of skeletal muscle L-type calcium channels.

1991 • 145 citations

Repeat I of the dihydropyridine receptor is critical in determining calcium channel activation kinetics

1991 • 145 citations

Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

1991 • 144 citations

Modulation of calcium channels of twitch skeletal muscle fibres of the frog by adrenaline and cyclic adenosine monophosphate.

1987 • 134 citations

Cloning, chromosomal localization, and functional expression of the alpha 1 subunit of the L-type voltage-dependent calcium channel from normal human heart.

1993 • 132 citations

Site‐specific phosphorylation of the purified receptor for calcium‐channel blockers by cAMP‐ and cGMP‐dependent protein kinases, protein kinase C, calmodulin‐dependent protein kinase II and casein kinase II

1988 • 131 citations

Activation of purified calcium channels by stoichiometric protein phosphorylation.

1989 • 131 citations

Subunit-dependent modulation of recombinant L-type calcium channels. Molecular basis for dihydropyridine tissue selectivity.

1993 • 128 citations

Molecular cloning and characterization of a novel calcium channel from rabbit brain

1992 • 128 citations

A β-subunit normalizes the electrophysiological properties of a cloned N-type CA2+ channel α1-subunit

1993 • 126 citations

Biochemical and ultrastructural characterization of the 1,4-dihydropyridine receptor from rabbit skeletal muscle. Evidence for a 52,000 Da subunit.

1988 • 120 citations

Calcium channels and calcium channel drugs: recent biochemical and biophysical findings.

1985 • 120 citations

A single nucleotide deletion in the skeletal muscle-specific calcium channel transcript of muscular dysgenesis (mdg) mice.

1992 • 119 citations

The 165‐KDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel

1987 • 117 citations

Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit.

1992 • 114 citations

Critical roles of the S3 segment and S3-S4 linker of repeat I in activation of L-type calcium channels.

1994 • 114 citations

Identification of the site of interaction of the dihydropyridine channel blockers nitrendipine and azidopine with the calcium-channel alpha 1 subunit.

1991 • 112 citations

Phosphorylation of the L‐type calcium channel β subunit is involved in β‐adrenergic signal transduction in canine myocardium

1993 • 111 citations

Cyclic AMP‐dependent phosphorylation and regulation of the cardiac dihydropyridine‐sensitive Ca channel

1992 • 109 citations

Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.

1992 • 108 citations

Purification of a functional receptor for calcium‐channel blockers from rabbit skeletal‐muscle microsomes

1986 • 107 citations

Dihydropyridine and phenylalkylamine receptors associated with cardiac and skeletal muscle calcium channels are structurally different.

1988 • 107 citations

Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

1992 • 106 citations

Molecular localization of regions in the L-type calcium channel critical for dihydropyridine action

1993 • 106 citations

Purified omega-conotoxin GVIA receptor of rat brain resembles a dihydropyridine-sensitive L-type calcium channel.

1991 • 105 citations

Phosphorylation of the purified receptor for calcium channel blockers by cAMP kinase and protein kinase C

1987 • 103 citations

Human neuronal voltage-dependent calcium channels: Studies on subunit structure and role in channel assembly

1993 • 99 citations

Tissue‐specific expression of high‐voltage‐activated dihydropyridine‐sensitive L‐type calcium channels

1991 • 99 citations

Short term and long term effects of beta-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle.

1985 • 98 citations

Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion

1993 • 96 citations

Regulation of the cloned L‐type cardiac calcium channel by cyclic‐AMP‐dependent protein kinase

1994 • 94 citations

Calcium channels in excitable cells: divergent genotypic and phenotypic expression of alpha 1-subunits

1994 • 93 citations

The cDNA and deduced amino acid sequence of the γ subunit of the L‐type calcium channel from rabbit skeletal muscle

1990 • 91 citations

cAMP-dependent protein kinase rapidly phosphorylates serine- 687 of the skeletal muscle receptor for calcium channel blockers.

1988 • 90 citations

Requirement of the calcium channel β subunit for functional conformation

1993 • 86 citations

Go transduces GABAB-receptor modulation of N-type calcium channels in cultured dorsal root ganglion neurons

1993 • 85 citations

Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene

1992 • 85 citations

Tissue heterogeneity of calcium channel antagonist binding sites labeled by [3H]nitrendipine.

1984 • 84 citations

Molecular characterization and nephron distribution of a family of transcripts encoding the pore-forming subunit of Ca2+ channels in the kidney.

1992 • 77 citations

The bovine cardiac receptor for calcium channel blockers is a 195‐kDa protein

1988 • 77 citations

Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle.

1991 • 73 citations

?-Subunit expression is required for cAMP-dependent increase of cloned cardiac and vascular calcium channel currents

1992 • 72 citations

Specific phosphorylation of a COOH-terminal site on the full-length form of the alpha 1 subunit of the skeletal muscle calcium channel by cAMP-dependent protein kinase.

1992 • 71 citations

Stable co‐expression of calcium channel alpha 1, beta and alpha 2/delta subunits in a somatic cell line.

1993 • 70 citations

Calcium channels from Cyprinus carpio skeletal muscle.

1991 • 70 citations

A monoclonal antibody to the beta subunit of the skeletal muscle dihydropyridine receptor immunoprecipitates the brain omega-conotoxin GVIA receptor.

1991 • 68 citations

mRNA for Cardiac Calcium Channel Is Expressed during Development of Skeletal Muscle

1993 • 66 citations

Cloning and characterization of a lambert‐eaton myasthenic syndrome antigen

1993 • 65 citations

Expression of dihydropyridine‐sensitive brain calcium channels in the rat central nervous system

1992 • 64 citations

Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart.

1993 • 64 citations

Characterization of β subunit modulation of a rabbit cardiac L‐type Ca²⁺ channel α₁ subunit as expressed in mouse L cells

1993 • 60 citations

A two-motif isoform of the major calcium channel subunit in skeletal muscle

1992 • 59 citations

Calcium channels: The β‐subunit increases the affinity of dihydropyridine and Ca²⁺ binding sites of the α₁‐subunit

1994 • 58 citations

T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits

1994 • 57 citations

Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation.

1994 • 54 citations

Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location

1993 • 52 citations

Characterization of cDNA clones encoding two putative isoforms of the α₁ subunit of the dihydropyridine-sensitive voltage-dependent calcium channel isolated from rat brain and rat aorta

1989 • 51 citations

Single-Channel Analysis of a Cloned Human Heart L-Type Ca2+ Channel α1 Subunit and the Effects of a Cardiac β Subunit

1993 • 49 citations

Cloning, chromosomal location and functional expression of the human voltage‐dependent calcium‐channel β3 subunit

1994 • 49 citations

Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell.

1992 • 47 citations

Assignment of the Human Gene for the α1 Subunit of the Skeletal Muscle DHP-Sensitive Ca2+ Channel (CACNL1A3) to Chromosome 1q31-q32

1993 • 47 citations

Molecular cloning of a murine N‐type calcium channel α1 subunit

1994 • 47 citations

Purification of putative Ca2+ channel protein from rabbit skeletal muscle. Determination of the amino-terminal sequence.

1987 • 46 citations

Quantification of two splicing events in the L‐type calcium channel α‐1 subunit of intestinal smooth muscle and other tissues

1994 • 45 citations

Molecular diversity of Ca2+ channel alpha 1 subunits from the marine ray Discopyge ommata.

1993 • 45 citations

Studies on the structural requirements for the activity of the skeletal muscle dihydropyridine receptor/slow Ca2+ channel. Allosteric regulation of dihydropyridine binding in the absence of alpha 2 and beta components of the purified protein complex.

1990 • 44 citations

Dihydropyridine-sensitive calcium channels expressed in canine colonic smooth muscle cells

1993 • 43 citations

Native‐type DHP‐sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac α₁ subunits expressed in Xenopus laevis ooeytes and are regulated by α₂‐ and β‐subunits

1992 • 43 citations

Cloning and Expression of a Novel Truncated Calcium Channel from Non-excitable Cells

1995 • 35 citations

Expression of a cDNA for a neuronal calcium channel alpha 1 subunit enhances secretion from adrenal chromaffin cells

1992 • 34 citations

Heterologous expression of calcium channels

1992 • 31 citations

A rapid procedure for the purification of cardiac 1,4-dihydropyridine receptors from porcine heart

1991 • 31 citations

A brain L-type calcium channel α1 subunit gene (CCHL1A2) maps to mouse chromosome 14 and human chromosome 3

1991 • 27 citations

Evidence for the existence of RNA of Ca2+-channel α2/δ subunit in Xenopus oocytes

1992 • 25 citations

Photoaffinity labeling of the calcium channel antagonist receptor in the heart of the cardiomyopathic hamster

1987 • 24 citations

Molecular Characterization of 1, 4-Dihydropyridine-Sensitive Calcium Channels of Chick Heart and Skeletal Muscle

1990 • 23 citations

Assignment of the Human Gene for the β Subunit of the Voltage-Dependent Calcium Channel (CACNLB1) to Chromosome 17 Using Somatic Cell Hybrids and Linkage Mapping

1993 • 22 citations

[35] Purification and reconstitution of skeletal muscle calcium channels

1992 • 21 citations

Cloning of a novel alpha 1-subunit of the voltage-dependent calcium channel from the beta-cell

1992 • 20 citations

Functional properties of the purified N-type Ca2+ channel from rabbit brain.

1994 • 20 citations

omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor

1991 • 17 citations

Purification of the cardiac 1,4-dihydropyridine receptor using immunoaffinity chromatography with a monoclonal antibody against the α2δ subunit of the skeletal muscle dihydropyridine receptor

1992 • 16 citations

Purification of L-Type Calcium Channel Drug Receptors

1991 • 16 citations

Expression and regulation of cardiac and smooth muscle calcium channels

1992 • 11 citations

Localization of the γ-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus

1993 • 11 citations

Evidence for Subtypes of the ω‐Conotoxin GVIA Receptor

1991 • 10 citations

Purification and Structure of L-Type Calcium Channels

2003 • 9 citations