Physicochemical characteristics of soluble oligomeric Aβand their pathologic role in Alzheimer's disease

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

2002 • 13,092 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo

2002 • 4,135 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Soluble pool of A? amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

1999 • 1,787 citations

Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease

1999 • 1,505 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 • 1,393 citations

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

2003 • 1,373 citations

Amyloid pores from pathogenic mutations

2002 • 1,260 citations

ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's Disease

2004 • 1,232 citations

Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models

1999 • 1,118 citations

Amyloid β-Protein Fibrillogenesis

1997 • 1,103 citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

1999 • 797 citations

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

2003 • 783 citations

Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.

1993 • 775 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

2002 • 699 citations

Cerebral Amyloid Angiopathy

1998 • 654 citations

Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology

2001 • 617 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Neuropathology and Pathogenesis of Encephalitis following Amyloid β Immunization in Alzheimer's Disease

2004 • 559 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Clearing the Brain's Amyloid Cobwebs

2001 • 538 citations

Self-Assembly of Aβ_1-42into Globular Neurotoxins

2003 • 510 citations

Amyloid-β oligomers: their production, toxicity and therapeutic inhibition

2002 • 491 citations

Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

1996 • 482 citations

Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β

2003 • 481 citations

The Oligomerization of Amyloid β-Protein Begins Intracellularly in Cells Derived from Human Brain

2000 • 479 citations

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 • 423 citations

Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease

1997 • 422 citations

In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life.

2003 • 422 citations

Drainage of Brain Extracellular Fluid into Blood and Deep Cervical Lymph and its Immunological Significance

1992 • 420 citations

Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide

1995 • 393 citations

Amyloid β-Protein Oligomerization

2001 • 380 citations

An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease

1997 • 368 citations

Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture

1995 • 365 citations

In VivoAssessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

2003 • 363 citations

Dimeric Amyloid β Protein Rapidly Accumulates in Lipid Rafts followed by Apolipoprotein E and Phosphorylated Tau Accumulation in the Tg2576 Mouse Model of Alzheimer's Disease

2004 • 343 citations

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

1996 • 328 citations

Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy

1998 • 323 citations

Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release

1998 • 313 citations

Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein

2002 • 281 citations

Circle of Willis Atherosclerosis Is a Risk Factor for Sporadic Alzheimer’s Disease

2003 • 278 citations

Pathways of Fluid Drainage from the Brain ‐ Morphological Aspects and Immunological Significance in Rat and Man

1992 • 276 citations

Specific Domains of β-Amyloid from Alzheimer Plaque Elicit Neuron Killing in Human Microglia

1996 • 268 citations

Increased Aβ Peptides and Reduced Cholesterol and Myelin Proteins Characterize White Matter Degeneration in Alzheimer's Disease

2002 • 267 citations

Cortical and Leptomeningeal Cerebrovascular Amyloid and White Matter Pathology in Alzheimer’s Disease

2003 • 266 citations

The production of amyloid beta peptide is a critical requirement for the viability of central neurons.

2003 • 263 citations

α₂‐Macroglobulin Complexes with and Mediates the Endocytosis of β‐Amyloid Peptide via Cell Surface Low‐Density Lipoprotein Receptor‐Related Protein

1997 • 259 citations

Amyloid β‐peptide interactions with neuronal and glial cell plasma membrane: binding sites and implications for Alzheimer's disease

2004 • 257 citations

Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

2004 • 254 citations

Aβ1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation

2000 • 237 citations

Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein.

1992 • 231 citations

Neurogenic Effect of -Amyloid Peptide in the Development of Neural Stem Cells

2004 • 228 citations

Pathology of Cerebrospinal Fluid and Interstitial Fluid of the CNS: Significance for Alzheimer Disease, Prion Disorders and Multiple Sclerosis

1998 • 226 citations

The CERAD Neuropathology Protocol and Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease: A Commentary

1997 • 226 citations

The channel hypothesis of Alzheimer’s disease: current status

2002 • 225 citations

The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-beta (Abeta) degradation and inhibits Abeta-induced neurodegeneration.

2003 • 222 citations

Molecular mechanism of neurodegeneration induced by Alzheimer’s β-amyloid protein: channel formation and disruption of calcium homeostasis

2000 • 221 citations

The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

2003 • 221 citations

Fresh and globular amyloid β protein (1–42) induces rapid cellular degeneration: evidence for AβP channel‐mediated cellular toxicity

2000 • 221 citations

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

2000 • 220 citations

Structural studies of soluble oligomers of the alzheimer β-amyloid peptide

2000 • 209 citations

Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form

2003 • 209 citations

Alterations in Cerebral Blood Flow and Glucose Utilization in Mice Overexpressing the Amyloid Precursor Protein

2002 • 203 citations

Soluble Amyloid Aβ-(1–40) Exists as a Stable Dimer at Low Concentrations

1997 • 202 citations

Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein

1997 • 200 citations

Aβ-peptides enhance vasoconstriction in cerebral circulation

2001 • 192 citations

The Tissue Plasminogen Activator-Plasminogen Proteolytic Cascade Accelerates Amyloid-β (Aβ) Degradation and Inhibits Aβ-Induced Neurodegeneration

2003 • 190 citations

Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red

1998 • 184 citations

Theoretical models of the ion channel structure of amyloid beta-protein

1994 • 176 citations

Transgenic mouse models of Alzheimer's disease

2001 • 175 citations

Isolation, Chemical Characterization, and Quantitation of Aβ 3-Pyroglutamyl Peptide from Neuritic Plaques and Vascular Amyloid Deposits

1997 • 174 citations

Protein unfolding by mitochondria

2000 • 165 citations

Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques

2001 • 162 citations

Residues 17–20 and 30–35 of beta‐amyloid play critical roles in aggregation

2003 • 161 citations

The HHQK Domain of β-Amyloid Provides a Structural Basis for the Immunopathology of Alzheimer's Disease

1998 • 161 citations

Neprilysin Regulates Amyloid β Peptide Levels

2004 • 154 citations

Gerstmann‐Sträussler‐Scheinker Disease and the Indiana Kindred

1995 • 147 citations

Cerebral Amyloid Angiopathy: Accumulation of Aβ in Interstitial Fluid Drainage Pathways in Alzheimer's Disease

2000 • 146 citations

Inhibition of Angiogenesis by A Peptides

2004 • 139 citations

α₂‐Macroglobulin Enhances the Clearance of Endogenous Soluble β‐Amyloid Peptide via Low‐Density Lipoprotein Receptor‐Related Protein in Cortical Neuron

1999 • 134 citations

Regional Distribution of Amyloid-Bri Deposition and Its Association with Neurofibrillary Degeneration in Familial British Dementia

2001 • 132 citations

Proteolysis of Aβ Peptide from Alzheimer Disease Brain by Gelatinase A

1994 • 129 citations

Familial Danish Dementia: A Novel Form of Cerebral Amyloidosis Associated with Deposition of Both Amyloid-Dan and Amyloid-Beta

2002 • 128 citations

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

2004 • 127 citations

Soluble Amyloid β-Protein Is a Marker of Alzheimer Amyloid in Brain But Not in Cerebrospinal Fluid

1994 • 126 citations

2-Methyl-3-Hydroxybutyryl-CoA Dehydrogenase Deficiency Is Caused by Mutations in the HADH2 Gene

2003 • 117 citations

Characteristics of thein VitroVasoactivity of β-Amyloid Peptides

1998 • 115 citations

Hippocampal Aβ42 Levels Correlate with Spatial Memory Deficit in APP and PS1 Double Transgenic Mice

2002 • 114 citations

Role of ERAB/l-3-Hydroxyacyl-coenzyme A Dehydrogenase Type II Activity in Aβ-induced Cytotoxicity

1999 • 113 citations

Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of Aβ peptides of Alzheimer's disease

1998 • 111 citations

Inducible nitric oxide synthase and argininosuccinate synthetase: co-induction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1–42 in vitro

2002 • 102 citations

Biochemical Evidence for the Long-Tail Form (Aβ1-42/43) of Amyloid β Protein as a Seed Molecule in Cerebral Deposits of Alzheimer′s Disease

1994 • 102 citations

Alternate Aggregation Pathways of the Alzheimer β-Amyloid Peptide: Aβ Association Kinetics at Endosomal pH

2002 • 101 citations

Distinct Steps in Dislocation of Luminal Endoplasmic Reticulum-associated Degradation Substrates

2004 • 97 citations

Cerebral metabolism in fatal familial insomnia: Relation to duration, neuropathology, and distribution of protease-resistent prion protein

1997 • 94 citations

A New Hypothesis for the Mechanism of Amyloid Toxicity, Based on the Calcium Channel Activity of Amyloid β Protein (AβP) in Phospholipid Bilayer Membranes

1993 • 92 citations

In vitro peroxidase oxidation induces stable dimers of β-amyloid (1-42) through dityrosine bridge formation

1999 • 88 citations

Cerebrovascular effects of amyloid-beta peptides: mechanisms and implications for Alzheimer's dementia.

2003 • 88 citations

Oligomerization and fibril assembly of the amyloid-β protein

2000 • 86 citations

Molecular modeling of the Abeta1-42 peptide from Alzheimer's disease

1998 • 82 citations

Cerebrovascular Disease Is a Major Factor in the Failure of Elimination of Aβ from the Aging Human Brain

2002 • 81 citations

Physiological levels ofβ-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production

2001 • 79 citations

Diversity of amyloid beta protein fragment [1-40]-formed channels.

2001 • 74 citations

Endoplasmic Reticulum‐Localized Amyloid β‐Peptide is Degraded in the Cytosol by Two Distinct Degradation Pathways

2003 • 72 citations

Inhibition of Alzheimer's β-Amyloid Induced Vasoactivity and Proinflammatory Response in Microglia by a cGMP-Dependent Mechanism

1999 • 71 citations

β-Amyloid Racemized at the Ser²⁶Residue in the Brains of Patients with Alzheimer Disease: Implications in the Pathogenesis of Alzheimer Disease

2003 • 66 citations

Detection of Apolipoprotein E/Dimeric Soluble Amyloid β Complexes in Alzheimer's Disease Brain Supernatants

1997 • 59 citations

Heterogeneous Amyloid-Formed Ion Channels as a Common Cytotoxic Mechanism

2002 • 58 citations

Modified Amyloid β Protein Ending at 42 or 40 with Different Solubility Accumulates in the Brain of Alzheimer′s Disease

1995 • 50 citations

Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: differentiation from amyloid plaque core protein.

1988 • 45 citations

Proteolytic Degradation of Alzheimer's Disease Amyloid β‐Peptide by a Metalloproteinase from Microglia Cells

1998 • 45 citations

Amyloid β‐protein (Aβ) associated with lipid molecules: immunoreactivity distinct from that of soluble Aβ

1997 • 44 citations

Dityrosine Cross-Linked Aβ Peptides: Fibrillar β-Structure in Aβ(1-40) Is Conducive to Formation of Dityrosine Cross-Links but a Dityrosine Cross-Link in Aβ(8-14) Does Not Induce β-Structure

2003 • 39 citations

Variant Gerstmann-Sträussler syndrome with the P105L prion gene mutation: an unusual case with nigral degeneration and widespread neurofibrillary tangles

1999 • 38 citations

Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia

2003 • 37 citations

Aβ Vasoactivity: An Inflammatory Reaction

2000 • 37 citations

Statins inhibit Aβ-neurotoxicity in vitro and Aβ-induced vasoconstriction and inflammation in rat aortae

2002 • 30 citations

Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies

1988 • 26 citations

Soluble β-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway

2000 • 24 citations

Variable Phenotype in a P102L Gerstmann-Sträussler-Scheinker Italian Family

2003 • 23 citations

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2001 • 23 citations

Creutzfeldt-Jakob disease with long duration and panencephalopathic lesions: Molecular analysis of one case

1998 • 21 citations

The Vasoactivity of Aβ Peptides

1997 • 19 citations

Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease.

2000 • 14 citations

Properties of neurotoxic peptides related to the BRI gene

2002 • 14 citations

Differences in the density and spatial distribution of florid and diffuse plaques in variant Creutzfeldt-Jakob disease (vCJD).

2003 • 11 citations

A case of sporadic Creutzfeldt‐Jakob disease with both plaque and synaptic‐type deposition of prion protein

2000 • 4 citations