Molecular mechanism of neurodegeneration induced by Alzheimer’s β-amyloid protein: channel formation and disruption of calcium homeostasis

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

1990 • 959 citations

Neurotoxicity of a prion protein fragment

1993 • 937 citations

Prion Protein Biology

1998 • 913 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Conformational disease

1997 • 794 citations

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

1995 • 691 citations

An Antimicrobial Peptide, Magainin 2, Induced Rapid Flip-Flop of Phospholipids Coupled with Pore Formation and Peptide Translocation

1996 • 688 citations

Amyloid diseases: Abnormal protein aggregation in neurodegeneration

1999 • 674 citations

Structure and Functions of Channel-Forming Peptides: Magainins, Cecropins, Melittin and Alamethicin

1997 • 590 citations

Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease

1999 • 554 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.

1999 • 483 citations

Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin

1996 • 439 citations

Cellular mechanisms of β-amyloid production and secretion

1999 • 431 citations

A detergent-insoluble membrance compartment contains Aβ in vivo

1998 • 394 citations

Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

1993 • 379 citations

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

1994 • 363 citations

Interaction of Alzheimer β-Amyloid Peptide(1−40) with Lipid Membranes

1997 • 346 citations

Amyloidogenicity of beta A4 and beta A4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation.

1992 • 344 citations

Membrane Disruption by Alzheimer β-Amyloid Peptides Mediated through Specific Binding to Either Phospholipids or Gangliosides

1996 • 323 citations

Alzheimer's β-Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line

2000 • 291 citations

Membrane Stiffness and Channel Function

1996 • 280 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

β-Amyloid protein-induced Alzheimer's disease animal model

1994 • 264 citations

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.

1996 • 259 citations

Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

1997 • 217 citations

Annexin V Staining Due to Loss of Membrane Asymmetry Can Be Reversible and Precede Commitment to Apoptotic Death

1999 • 194 citations

Aluminum Promotes the Aggregation of Alzheimer′s Amyloid β-Protein in Vitro

1994 • 193 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Theoretical models of the ion channel structure of amyloid beta-protein

1994 • 176 citations

Alzheimer .beta.-Amyloid Peptide 25-35: Electrostatic Interactions with Phospholipid Membranes

1994 • 171 citations

?-amyloid Ca2+-channel hypothesis for neuronal death in Alzheimer Disease

1994 • 165 citations

Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

1999 • 152 citations

The Formation of Amphotericin B Ion Channels in Lipid Bilayers

1997 • 146 citations

Alzheimer amyloid aβ1-42 channels: Effects of solvent, pH, and congo red

1999 • 138 citations

Channel Formation in Planar Lipid Bilayers by a Neurotoxic Fragment of the β-Amyloid Peptide

1994 • 127 citations

Tau protein I is essential for amyloid β-protein iduced neurotoxicity

1993 • 125 citations

Ionic effects of the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments

1997 • 124 citations

Neurotoxicity of Human Amylin in Rat Primary Hippocampal Cultures: Similarity to Alzheimer's Disease Amyloid‐β Neurotoxicity

1993 • 122 citations

Impairments of long-term potentiation in hippocampal slices of β-amyloid-infused rats

1999 • 119 citations

β-Amyloid neurotoxicity: A discussion of in vitro findings

1992 • 113 citations

Transmembrane phospholipid distribution in blood cells: control mechanisms and pathophysiological significance.

1998 • 112 citations

Transbilayer Distribution of Cholesterol Is Modified in Brain Synaptic Plasma Membranes of Knockout Mice Deficient in the Low‐Density Lipoprotein Receptor, Apolipoprotein E, or Both Proteins

1997 • 107 citations

Optical monitoring of excitatory synaptic activity between cultured hippocampal neurons by a multi-site Ca2+ fluorometry

1987 • 99 citations

Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity

1995 • 91 citations

Membrane Components Separate Early-Onset Alzheimer's Disease From Senile Dementia of the Alzheimer Type

1996 • 84 citations

Caffeine Stimulates Amyloid β‐Peptide Release from β‐Amyloid Precursor Protein‐Transfected HEK293 Cells

1997 • 76 citations

Apolipoprotein B immunoreactivity in senile plaque and vascular amyloids and neurofibrillary tangles in the brains of patients with Alzheimer's disease

1992 • 72 citations

Amyloid β protein-induced irreversible current in rat cortical neurones

1994 • 68 citations

Temporal Relations Among Amyloid β-Peptide-Induced Free-Radical Oxidative Stress, Neuronal Toxicity, and Neuronal Defensive Responses

1998 • 61 citations

Block of synapse formation between cerebral cortical neurons by a protein kinase inhibitor

1992 • 52 citations

Aggregation of Amyloid .BETA.-Protein and Its Neurotoxicity: Enhancement by Aluminum and Other Metals.

1994 • 48 citations

Amyloid β-peptide(25-35) changes [Ca2+] in hippocampal neurons

1998 • 47 citations

beta-Amyloid neurotoxicity.

1993 • 46 citations

L-Type Ca<sup>2+</sup> Channels Mediate Joint Modulation by Gamma-Amino-butyric Acid and Glutamate of [Ca<sup>2+</sup>]<sub>i</sub> and Neuropeptide Secretion in Immortalized Gonadodropin-Releasing Hormone Neurons

1995 • 44 citations

Cholesterol protects PC12 cells from β-amyloid induced calcium disordering and cytotoxicity

1996 • 39 citations

Senile dementia of Alzheimer type characterized by laminar neuronal loss exclusively in the hippocampus, parahippocampus and medial occipitotemporal cortex

1990 • 37 citations

Domain formation induced by lipid-ion and lipid-peptide interactions

1995 • 32 citations

Amyloid β peptide enhanced bradykinin-mediated inositol (1,4,5)trisphosphate formation and cytosolic free calcium

1998 • 19 citations