Characteristics of thein VitroVasoactivity of β-Amyloid Peptides

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1997 • 1,970 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease<subtitle>The Nun Study</subtitle>

1997 • 1,509 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

Brain Infarction and the Clinical Expression of Alzheimer Disease-Reply

1997 • 704 citations

β-Amyloid-mediated vasoactivity and vascular endothelial damage

1996 • 686 citations

The toxicity in vitro of β-amyloid protein

1995 • 427 citations

The clinical spectrum of cerebral amyloid angiopathy

1993 • 354 citations

Cerebral Infarction in Alzheimer's Disease Is Associated With Severe Amyloid Angiopathy and Hypertension

1995 • 226 citations

Amyloid β peptide induces necrosis rather than apoptosis

1994 • 221 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

Apolipoprotein E ϵ4 and the Risk of Dementia With Stroke<subtitle>A Population-Based Investigation</subtitle>

1997 • 195 citations

Degeneration of vascular muscle cells in cerebral amyloid angiopathy of Alzheimer disease

1993 • 183 citations

Ischemic stress induces deposition of amyloid ? immunoreactivity in human brain

1995 • 156 citations

Altered gene expression in cerebral ischemia.

1993 • 146 citations

The blood-brain barrier and cerebral microcirculation in Alzheimer disease.

1992 • 131 citations

Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic stimulation of pineal cAMP and cGMP by K+ and A23187.

1988 • 130 citations

Production and increased detection of amyloid β protein and amyloidogenic fragments in brain microvessels, meningeal vessels and choroid plexus in Alzheimer's disease

1996 • 117 citations

β-amyloid peptide in vitro toxicity: Lot-to-lot variability

1992 • 116 citations

Increased Amyloid Protein Precursor and Apolipoprotein E Immunoreactivity in the Selectively Vulnerable Hippocampus Following Transient Forebrain Ischemia in Gerbils

1995 • 113 citations

Glial Expression of the β-Amyloid Precursor Protein (APP) in Global Ischemia

1995 • 103 citations

Stimulation of cyclic GMP production in cultured endothelial cells of the pig by bradykinin, adenosine diphosphate, calcium ionophore A23187 and nitric oxide

1990 • 96 citations

Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity

1995 • 91 citations

Superoxide free radical and intracellular calcium mediate Aβ1–42 induced endothelial toxicity

1997 • 84 citations

The Amyloid Precursor Protein in Ischemic Brain Injury and Chronic Hypoperfusion^a

1993 • 84 citations

Astrocytes in Alzheimer's disease express immunoreactivity to the vaso-constrictor endothelin-1

1994 • 81 citations

Endothelium-dependent relaxation of rabbit aorta. II. Inhibition of relaxation stimulated by methacholine and A23187 with antagonists of arachidonic acid metabolism.

1983 • 74 citations

New developments in the understanding of cerebral vasoregulation and vasospasm: the endothelin-nitric oxide network

1995 • 72 citations

Heparan sulfate and chondroitin sulfate glycosaminoglycan attenuate β-amyloid(25–35) induced neurodegeneration in cultured hippocampal neurons

1995 • 68 citations

Neuropathology of Alzheimer's disease

1989 • 64 citations

Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients

1996 • 62 citations

Cerebrovascular endothelial dysfunction mediated by β-amyloid

1997 • 58 citations

Increased β‐Amyloid Precursor Protein Expression in Astrocytes in the Gerbil Hippocampus Following Ischaemia: Association with Proliferation of Astrocytes

1995 • 55 citations

ETA Receptors Predominate in the Human Vasculature and Mediate Constriction

1995 • 53 citations

ETA Receptors Predominate in the Human Vasculature and Mediate Constriction

1995 • 53 citations

Endothelins as Regulators of Vascular Tone in Man

1995 • 50 citations

Nitric oxide and endothelin in pathophysiological settings

1995 • 49 citations

Cerebral amyloid angiopathy presenting as transient ischemic attacks

1985 • 46 citations

Endothelin-1-like immunoreactivity in cerebral cortex of Alzheimer-type dementia

1995 • 38 citations

Loss of vessel wall viability in cerebral amyloid angiopathy

1996 • 34 citations

Endothelium-lndependent Relaxations to Acetylcholine and A23187 in the Human Umbilical Artery

1994 • 28 citations

Autocrine Regulation of the Endothelin-1 Gene in Rat Endothelial Cells

1995 • 28 citations

The Neuropathology of Alzheimer's Disease

1996 • 28 citations

Autocrine Regulation of the Endothelin-1 Gene in Rat Endothelial Cells

1995 • 27 citations

Characterization of endothelinA receptors in cerebral and peripheral arteries of the rat

1995 • 21 citations

Cerebrospinal fluid endothelin-1 in Alzheimer's disease and senile dementia of Alzheimer type

1992 • 20 citations

Effects of the potassium channel openers KRN4884 and levcromakalim on the contraction of rat aorta induced by A23187, compared with nifedipine

1996 • 14 citations

Degeneration of amyloid precursor protein containing smooth muscle cells in cerebral amyloid angiopathy

1993 • 11 citations

Potassium Channel Openers Relax A23187-Induced Nifedipine-Resistant Contraction of Rat Aorta

1994 • 9 citations

Antagonism by paraquat of the relaxing effects of acetylcholine and A23187 in rat thoracic aorta

1995 • 8 citations

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