Heterogeneous Amyloid-Formed Ion Channels as a Common Cytotoxic Mechanism

Ionic channels of excitable membranes

1985 • 7,199 citations

Brain natriuretic peptide as a novel cardiac hormone in humans. Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide.

1991 • 1,358 citations

C-Type natriuretic peptide (CNP): A new member of natriuretic peptide family identified in porcine brain

1990 • 1,099 citations

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

1993 • 901 citations

Cellular and molecular biology of voltage-gated sodium channels

1992 • 837 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Selective Activation of the B Natriuretic Peptide Receptor by C-Type Natriuretic Peptide (CNP)

1991 • 722 citations

Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.

1992 • 710 citations

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1999 • 600 citations

Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

1993 • 549 citations

Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons

1998 • 546 citations

Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-beta. Possible existence of "vascular natriuretic peptide system".

1992 • 528 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 520 citations

Pore Formation by the Cytotoxic Islet Amyloid Peptide Amylin

1996 • 439 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

C-TYPE NATRIURETIC PEPTIDE (CNP) IN RATS AND HUMANS

1991 • 299 citations

Alzheimer's β-Amyloid, Human Islet Amylin, and Prion Protein Fragment Evoke Intracellular Free Calcium Elevations by a Common Mechanism in a Hypothalamic GnRH Neuronal Cell Line

2000 • 291 citations

Copper and Zinc Binding Modulates the Aggregation and Neurotoxic Properties of the Prion Peptide PrP106−126

2001 • 261 citations

Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.

1996 • 259 citations

Potassium channel stimulation by natriuretic peptides through cGMP-dependent dephosphorylation

1993 • 258 citations

Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells--evidence for CNP as a novel autocrine/paracrine regulator from endothelial cells.

1993 • 243 citations

Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons

1997 • 217 citations

Antioxidant activity related to copper binding of native prion protein

2001 • 217 citations

Channel Formation by a Neurotoxic Prion Protein Fragment

1997 • 191 citations

Cloning and sequence analysis of a cDNA encoding a precursor for rat C‐type natriuretic peptide (CNP)

1990 • 178 citations

Theoretical models of the ion channel structure of amyloid beta-protein

1994 • 176 citations

?-amyloid Ca2+-channel hypothesis for neuronal death in Alzheimer Disease

1994 • 165 citations

Alzheimer amyloid abeta1-42 channels: effects of solvent, pH, and Congo Red.

1999 • 152 citations

Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide

1997 • 150 citations

Detection of C-Type Natriuretic Peptide in Human Circulation and Marked Increase of Plasma CNP Level in Septic Shock Patients

1994 • 141 citations

Cardiovascular and renal actions of C-type natriuretic peptide

1992 • 139 citations

Channel Formation in Planar Lipid Bilayers by a Neurotoxic Fragment of the β-Amyloid Peptide

1994 • 127 citations

Expression of Atrial and Brain Natriuretic Peptides and Their Genes in Hearts of Patients With Cardiac Amyloidosis

1998 • 115 citations

Relationship between force and Ca2+ concentration in smooth muscle as revealed by measurements on single cells.

1988 • 115 citations

Vascular Actions of C-Type Natriuretic Peptide in Isolated Porcine Coronary Arteries and Coronary Vascular Smooth Muscle Cells

1994 • 100 citations

Ion channel hypothesis for Alzheimer amyloid peptide neurotoxicity

1995 • 91 citations

Neurotoxicity of acetylcholinesterase amyloid β‐peptide aggregates is dependent on the type of Aβ peptide and the AChE concentration present in the complexes

1999 • 88 citations

Effect of pH and insulin on fibrillogenesis of islet amyloid polypeptide in vitro

1995 • 88 citations

Prion peptide fragment PrP[106-126] forms distinct cation channel types

2000 • 82 citations

Intracellular Calcium Rise through L-Type Calcium Channels, as Molecular Mechanism for Prion Protein Fragment 106-126-Induced Astroglial Proliferation

1996 • 78 citations

Amyloidogenic determinant as a substrate recognition motif of insulin‐degrading enzyme

1998 • 77 citations

Diversity of amyloid beta protein fragment [1-40]-formed channels.

2001 • 74 citations

Amyloid peptide channels: Blockade by zinc and inhibition by Congo red (amyloid channel block)

2000 • 72 citations

Mechanisms of amyloid beta protein-induced modification in ion transport systems: implications for neurodegenerative diseases.

2001 • 68 citations

N-bromoacetamide removes a calcium-dependent component of channel opening from calcium-activated potassium channels in rat skeletal muscle.

1985 • 59 citations

Influence of β-Sheet Structure on the Susceptibility of Proteins to Backbone Oxidative Damage: Preference for ^αC-Centered Radical Formation at Glycine Residues of Antiparallel β-Sheets

2000 • 56 citations

A pharmacological and biochemical investigation of the venom from the platypus (Ornithorhynchus anatinus)

1995 • 54 citations

The secreted form of the Alzheimer's β-amyloid precursor protein stimulates a membrane-associated guanylate cyclase

1995 • 52 citations

Evaluation of the swimming activity of Daphnia magna by image analysis after administration of sublethal Cadmium concentrations

1998 • 51 citations

Neurotoxicity of prion peptide 106‐126 not confirmed

1999 • 50 citations

Spontaneous Deamidation and Isomerization of Asn108 in Prion Peptide 106–126 and in Full-Length Prion Protein

1999 • 49 citations

Receptor-regulated ion channels

1997 • 45 citations

The natriuretic peptide (ovCNP-39) from platypus (Ornithorhynchus anatinus) venom relaxes the isolated rat uterus and promotes oedema and mast cell histamine release

1998 • 43 citations

C-type natriuretic peptides stimulate chloride secretion in the rectal gland of Squalus acanthias

1992 • 42 citations

Mechanisms of prion-induced modifications in membrane transport properties: Implications for signal transduction and neurotoxicity

2001 • 40 citations

Channel activity of deamidated isoforms of prion protein fragment 106–126 in planar lipid bilayers

2001 • 39 citations

Promotion of β-structure by interaction of diabetes associated polypeptide (amylin) with phosphatidylcholine

1992 • 39 citations

Intrinsic Physiological and Morphological Properties of Principal Cells of the Hippocampus and Neocortex in Hamsters Infected with Scrapie

1999 • 36 citations

A C-type natriuretic peptide from the venom of the platypus (Ornithorhynchus anatinus): Structure and pharmacology

1998 • 35 citations

Role of natriuretic peptides in ion transport mechanisms

1999 • 34 citations

Synthetic mammalian C‐type natriuretic peptide forms large cation channels

1999 • 34 citations

Characterization of a C‐type natriuretic peptide (CNP‐39)‐formed cation‐selective channel from platypus (Ornithorhynchus anatinus) venom

1999 • 30 citations

Effects of Brain Natriuretic Peptide and C-Type Natriuretic Peptide Infusion on Urine Flow and Jejunal Absorption in Anesthetized Dogs.

1992 • 28 citations

In vivo activation of CFTR-dependent chloride transport in murine airway epithelium by CNP

1997 • 26 citations

Identification of a Chameleon-like pH-Sensitive Segment within the Colicin E1 Channel Domain That May Serve as the pH-Activated Trigger for Membrane Bilayer Association

1997 • 21 citations

Regulation of amiloride-sensitive sodium absorption in murine airway epithelium by C-type natriuretic peptide

1998 • 20 citations

Ultrastructural evidence for the formation of amyloid fibrils within cardiomyocytes in isolated atrial amyloid

1998 • 17 citations

Properties and modulation of alpha human atrial natriuretic peptide (α-hANP)-formed ion channels

2001 • 15 citations

Fractionation, primary structural characterisation and biological activities of polypeptides from the venom of the platypus (Ornithorhynchus anatinus)

1998 • 13 citations

Calcium dependence of C-type natriuretic peptide-formed fast K⁺channel

1999 • 12 citations

Calcium-Dependent Potassium Channels

1993 • 10 citations

Theoretical Analysis of the Implication of PrP in Neuronal Death during Transmissible Subacute Spongiform Encephalopathies: Hypothesis of a PrP Oligomeric Channel

2000 • 9 citations