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Catabolic response to stress and potential benefits of nutrition support

Data up to Jan 2025

Published2002
Citations114
References130

Total Citations Per Year

Abstract

References (130)

Intensive Insulin Therapy in Critically Ill Patients

2001 • 9,943 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Arginine metabolism: nitric oxide and beyond

1998 • 2,697 citations

The Biology of heat shock proteins and molecular chaperones.

1994 • 1,226 citations

The biology of heat shock proteins and molecular chaperones

1994 • 1,203 citations

Enteral Versus Parenteral Feeding Effects on Septic Morbidity After Blunt and Penetrating Abdominal Trauma

1992 • 1,163 citations

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

2000 • 971 citations

INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS

1999 • 894 citations

TEN versus TPN following Major Abdominal Trauma—Reduced Septic Morbidity

1989 • 829 citations

Multiple Organ Failure

1999 • 820 citations

Leucine. A possible regulator of protein turnover in muscle.

1975 • 746 citations

Benefits of Immediate Jejunostomy Feeding after Major Abdominal Trauma???A Prospective, Randomized Study

1986 • 717 citations

Compared with parenteral nutrition, enteral feeding attenuates the acute phase response and improves disease severity in acute pancreatitis

1998 • 692 citations

Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma

1998 • 633 citations

Regulation of gene expression by insulin

1996 • 543 citations

Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition

1997 • 534 citations

Immunonutrition in the critically ill: A systematic review of clinical outcome

1999 • 500 citations

Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo-controlled randomized trial.

1995 • 467 citations

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin–proteasome degradation

2001 • 431 citations

What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

2001 • 412 citations

Mechanism of Prevention of Postburn Hypermetabolism and Catabolism by Early Enteral Feeding

1984 • 409 citations

Effects of Recombinant Human Growth Hormone on Donor-site Healing in Severely Burned Children

1990 • 396 citations

Addition of Glutamine to Total Parenteral Nutrition After Elective Abdominal Surgery Spares Free Glutamine in Muscle, Counteracts the Fall in Muscle Protein Synthesis, and Improves Nitrogen Balance

1989 • 389 citations

A Randomized Trial of Isonitrogenous Enteral Diets After Severe Trauma

1996 • 387 citations

Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

1996 • 347 citations

1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones

1994 • 342 citations

Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle

1982 • 332 citations

Glucocorticoids and muscle catabolism

1999 • 290 citations

A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle

1987 • 285 citations

Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation

2001 • 285 citations

Cortisol-Induced Suppression of Plasma Testosterone in Normal Adult Males

1976 • 277 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

The effect of route of nutrient administration on the nutritional state, catabolic hormone secretion, and gut mucosal integrity after burn injury

1987 • 263 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Early Enteral Nutrition Support in Patients Undergoing Liver Transplantation

1995 • 237 citations

Stimulation of Muscle Protein Synthesis by Long-Term Insulin Infusion in Severely Burned Patients

1995 • 234 citations

Glutamine dipeptide-supplemented parenteral nutrition maintains intestinal function in the critically III

1994 • 217 citations

Polymeric enteral diets as primary treatment of active Crohn's disease: a prospective steroid controlled trial.

1993 • 215 citations

Grains or Veins: Is Enteral Nutrition Really Better Than Parenteral Nutrition? A Look at the Evidence

1998 • 211 citations

Enteral versus parenteral feeding

2012 • 209 citations

Insulin and IGF-I induce pronounced hypertrophy of skeletal myofibers in tissue culture

1991 • 204 citations

Metabolic response to injury and sepsis: changes in protein metabolism

1997 • 201 citations

Enteral versus parenteral nutrition as adjunct therapy in acute ulcerative colitis.

1993 • 200 citations

Role of Arginine in Trauma, Sepsis, and Immunity

1990 • 199 citations

Metabolic and Immune Effects of Dietary Arginine Supplementation After Burn

1987 • 198 citations

Muscle Protein Catabolism After Severe Burn: Effects of IGF-1/IGFBP-3 Treatment

1999 • 192 citations

Sepsis stimulates release of myofilaments in skeletal muscle by a calcium‐dependent mechanism

1999 • 191 citations

Loss of Upper Respiratory Tract Immunity with Parenteral Feeding

1996 • 189 citations

Arginine-Supplemented Diets Improve Survival in Gut-Derived Sepsis and Peritonitis by Modulating Bacterial Clearance The Role of Nitric Oxide

1993 • 170 citations

Physiological hypercortisolemia increases proteolysis, glutamine, and alanine production

1988 • 165 citations

ENTERAL VERSUS PARENTERAL NUTRITION AFTER SEVERE CLOSED HEAD INJURY

1994 • 163 citations

Cortisol and Corticotrophin in Burned Patients

1982 • 156 citations

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

1998 • 155 citations

Metabolic Response to Injury and Sepsis: Changes in Protein Metabolism

1997 • 150 citations

Urinary excretion of 3-methylhistidine: An assessment of muscle protein catabolism in adult normal subjects and during malnutrition, sepsis, and skeletal trauma

1981 • 148 citations

Molecular Regulation of Muscle Cachexia: It May Be More Than the Proteasome

2002 • 147 citations

Total and myofibrillar protein breakdown in different types of rat skeletal muscle: Effects of sepsis and regulation by insulin

1989 • 147 citations

Inhibition of protein breakdown by glutamine in perfused rat skeletal muscle

1988 • 147 citations

Tripeptidyl peptidases: enzymes that count

1999 • 145 citations

The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle

1998 • 140 citations

Insulin-Like Growth Factor-1 Lowers Protein Oxidation in Patients with Thermal Injury

1994 • 135 citations

Inactivity Amplifies the Catabolic Response of Skeletal Muscle to Cortisol*

1999 • 134 citations

Evidence That Tumor Necrosis Factor Participates in the Regulation of Muscle Proteolysis During Sepsis

1992 • 133 citations

Insulinlike Growth Factor 1 (IGF-1) Reduces Gut Atrophy and Bacterial Translocation After Severe Burn Injury

1993 • 122 citations

Growth Hormone Treatment In Pediatric Burns

1998 • 115 citations

Nutritional Support and Neurotrauma: A Critical Review of Early Nutrition in Forty-Five Acute Head Injury Patients

1986 • 115 citations

Effect of enteral and parenteral feeding in malnourished rats with E. coli-Hemoglobin adjuvant peritonitis

1981 • 108 citations

The COP/DET/FUS proteins—regulators of eukaryotic growth and development

2000 • 108 citations

Increased Survival after Major Thermal Injury

1995 • 107 citations

DEXAMETHASONE STIMULATES PROTEASOME- AND CALCIUM-DEPENDENT PROTEOLYSIS IN CULTURED L6 MYOTUBES

1998 • 103 citations

The Transcription Factors NF-κB and AP-1 Are Differentially Regulated in Skeletal Muscle during Sepsis

2001 • 100 citations

Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.

1995 • 99 citations

Effects of Glutamine Supplementation on Circulating Lymphocytes After Bone Marrow Transplantation: A Pilot Study

1998 • 99 citations

Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis

1999 • 97 citations

Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures

1995 • 88 citations

Effects of insulin on muscle tissue

2000 • 88 citations

The effect of insulin-like growth factor I on postburn hypermetabolism.

1990 • 87 citations

C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle

2002 • 85 citations

Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors

1998 • 84 citations

Growth Hormone and Cortisol Secretion in Patients With Burn Injury

1992 • 81 citations

Post injury hypermetabolic response and magnitude of translocation: prevention by early enteral nutrition.

1994 • 75 citations

Increased survival after major thermal injury

1987 • 74 citations

Effect of growth hormone therapy in burn patients on conservative treatment

1998 • 68 citations

Secretion of C-reactive protein becomes more efficient during the course of the acute phase response.

1985 • 66 citations

The Critical Role of the Ubiquitin-Proteasome Pathway in Muscle Wasting in Comparison to Lysosomal and Ca2+-Dependent Systems

1998 • 65 citations

Inactivity Amplifies the Catabolic Response of Skeletal Muscle to Cortisol

1999 • 64 citations

DANTROLENE REDUCES SERUM TNFα AND CORTICOSTERONE LEVELS AND MUSCLE CALCIUM, CALPAIN GENE EXPRESSION, AND PROTEIN BREAKDOWN IN SEPTIC RATS

2001 • 63 citations

Respiratory muscle injury in animal models and humans.

1998 • 59 citations

Dantrolene ameliorates the metabolic hallmarks of sepsis in rats and improves survival in a mouse model of endotoxemia.

1994 • 57 citations

Sepsis-Induced Muscle Proteolysis Is Prevented by a Proteasome Inhibitor in Vivo

2000 • 55 citations

The Gene Expression of Ubiquitin Ligase E3α Is Upregulated in Skeletal Muscle during Sepsis in Rats—Potential Role of Glucocorticoids

2000 • 55 citations

Enteral feeding in sepsis: a prospective, randomized, double-blind trial.

1985 • 54 citations

Insulin Resistance in Burns and Trauma

2009 • 53 citations

Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats

1998 • 53 citations

Glutamine: establishing clinical indications

1999 • 51 citations

Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle

1998 • 51 citations

Glutamine-containing dipeptides as infusion substrates in the septic state.

1989 • 50 citations

Reduced muscle protein breakdown in septic rats following treatment with interleukin-1 receptor antagonist

1994 • 47 citations

Insulin-Like Growth Factor I Reduces Ubiquitin and Ubiquitin-Conjugating Enzyme Gene Expression but Does Not Inhibit Muscle Proteolysis in Septic Rats*

2000 • 45 citations

Effect of starvation or treatment with corticosterone on the amount of easily releasable myofilaments in rat skeletal muscles

1986 • 45 citations

Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle

2000 • 44 citations

Systemic and splanchnic metabolic response to exogenous human growth hormone

1998 • 44 citations

Sepsis in mice stimulates muscle proteolysis in the absence of IL-6

1998 • 42 citations

Tumour necrosis factor (TNF) and interleukin‐1 (IL‐1) induce muscle proteolysis through different mechanisms

1992 • 41 citations

Growth hormone modulates amino acid oxidation in the surgical patient: Leucine kinetics during the fasted and fed state using moderate nitrogenous and caloric diet and recombinant human growth hormone

1997 • 40 citations

Sepsis is associated with increased ubiquitinconjugating enzyme E214k mRNA in skeletal muscle

1999 • 38 citations

Immunonutrition in the critically ill

1999 • 38 citations

Anabolic and cardiovascular effects of recombinant human growth hormone in surgical patients with sepsis

1996 • 37 citations

Anabolic and cardiovascular effects of recombinant human growth hormone in surgical patients with sepsis

1996 • 35 citations

Dantrolene Downregulates the Gene Expression and Activity of the Ubiquitin–Proteasome Proteolytic Pathway in Septic Skeletal Muscle

2002 • 35 citations

IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats

1998 • 34 citations

The effects of rate and route of nutrient intake on protein metabolism

1986 • 32 citations

NUTRITIONAL IMMUNOMODULATION ENHANCES CARDIAC ALLOGRAFT SURVIVAL IN RATS TREATED WITH DONOR-SPECIFIC TRANSFUSION AND CYCLOSPORINE

1995 • 32 citations

Growth hormone together with glutamine-containing total parenteral nutrition maintains muscle glutamine levels and results in a less negative nitrogen balance after surgical trauma

2001 • 31 citations

Increased intestinal protein synthesis during sepsis and following the administration of tumour necrosis factor α or interleukin-1 α

1992 • 30 citations

Heat shock protects L6 myotubes from catabolic effects of dexamethasone and prevents downregulation of NF-κB

2001 • 27 citations

Perioperative growth hormone treatment increases nitrogen and fluid balance and results in short-term and long-term conservation of lean tissue mass.

1998 • 26 citations

Protein Synthesis and Degradation in Skeletal Muscle From Septic Rats

1988 • 26 citations

Effects of Enteral and Parenteral Feeding of Malnourished Rats on Body Composition

1982 • 26 citations

Effects of branched-chain-enriched amino acids and insulin on forearm leucine kinetics

1999 • 25 citations

Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats

1998 • 22 citations

Burn injury upregulates the activity and gene expression of the 20 S proteasome in rat skeletal muscle

2000 • 22 citations

Insulin-Like Growth Factor I Reduces Ubiquitin and Ubiquitin-Conjugating Enzyme Gene Expression but Does Not Inhibit Muscle Proteolysis in Septic Rats

2000 • 21 citations

Management of catabolism in metabolically stressed patients: a literature survey about growth hormone application

2001 • 18 citations

Regulation by insulin of muscle protein metabolism during sepsis and other catabolic conditions.

1992 • 17 citations

Is Muscle Protein Turnover Regulated by Intracellular Glutamine During Sepsis?

1995 • 15 citations

Metabolic Effects of Adjuvant Recombinant Human Growth Hormone in Patients With Continuing Sepsis Receiving Parenteral Nutrition

1998 • 14 citations

Effects of branched-chain-enriched amino acids and insulin on forearm leucine kinetics

1999 • 9 citations

Enteral feeding in sepsis

1986 • 2 citations

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