Protein Synthesis and Degradation in Skeletal Muscle From Septic Rats

Sepsis and septic shock—A review of laboratory models and a proposal

1980 • 1,441 citations

A fluorometric method for the estimation of tyrosine in plasma and tissues.

1957 • 973 citations

Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

1975 • 916 citations

Leucine. A possible regulator of protein turnover in muscle.

1975 • 746 citations

Muscle Proteolysis Induced by a Circulating Peptide in Patients with Sepsis or Trauma

1983 • 469 citations

Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle?

1982 • 445 citations

OBSERVATIONS ON THE DISTURBANCE OF METABOLISM PRODUCED BY INJURY TO THE LIMBS

1932 • 337 citations

Effect of sepsis on tissue adenine nucleotide levels.

1979 • 329 citations

Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles

1976 • 284 citations

Influence of amino acid availability on protein turnover in perfused skeletal muscle

1978 • 277 citations

" CATABOLIC " LOSS OF BODY NITROGEN IN RESPONSE TO SURGERY

1974 • 271 citations

Leupeptin, a Protease Inhibitor, Decreases Protein Degradation in Normal and Diseased Muscles

1978 • 267 citations

Amino Acid Derangements in Patients With Sepsis

1978 • 225 citations

Branched chains support postoperative protein synthesis.

1982 • 152 citations

Failure of leucine to stimulate protein synthesis in vivo

1982 • 151 citations

Proteolysis associated with a deficit of peripheral energy fuel substrates in septic man.

1976 • 142 citations

Effect of Starvation on the Turnover and Metabolic Response to Leucine

1978 • 138 citations

Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.

1981 • 123 citations

Branched chain amino acid administration and metabolism during starvation, injury, and infection.

1979 • 118 citations

[10] In vitro preparations of the diaphragm and other skeletal muscles

1975 • 118 citations

Protein Metabolism in Different Types of Skeletal Muscle During Early and Late Sepsis in Rats

1986 • 114 citations

Branched Chain Amino Acid-Enriched Solutions in the Septic Patient

1986 • 110 citations

Specificity of the effects of leucine and its metabolites on protein degradation in skeletal muscle

1984 • 107 citations

Urinary excretion and efflux from the leg of 3-methylhistidine before and after major surgical operation

1984 • 97 citations

Studies concerning the specificity of the effect of leucine on the turnover of proteins in muscles of control and diabetic rats

1977 • 96 citations

Effects of Leucine on in Vitro Protein Synthesis and Degradation in Rat Skeletal Muscles

1984 • 90 citations

Changes of Protein Metabolism in Liver and Skeletal Muscle following Trauma Complicated by Sepsis

1984 • 90 citations

Systemic response to thermal injury in rats. Accelerated protein degradation and altered glucose utilization in muscle.

1984 • 88 citations

The measurement of protein synthesis in biological systems

1982 • 78 citations

EFFECTS OF α-KETOISOCAPROATE AND OF LEUCINE ON NITROGEN METABOLISM IN POSTOPERATIVE PATIENTS

1983 • 74 citations

Comparison of protein synthesis and degradation in incubated and perfused muscle

1983 • 69 citations

Inhibited Muscle Amino Acid Uptake in Sepsis

1986 • 67 citations

High‐Branched Chain Amino Acid Solutions: Relationship of Composition to Efficacy

1984 • 60 citations

Effect of insulin and leucine on protein turnover in rat soleus muscle after burn injury.

1982 • 55 citations

The effect of branched chain amino acids and hypertonic glucose infusions on postinjury catabolism in the rat.

1980 • 41 citations

Effects of temperature on protein turnover in isolated rat skeletal muscle

1984 • 33 citations

Use of a branched chain amino acid enriched solution in patients under metabolic stress

1985 • 31 citations

The Optimal Branched‐Chain to Total Amino Acid Ratio in the Injury‐Adapted Amino Acid Formulation

1985 • 18 citations

Amino acid pools in cultured muscle cells

1984 • 14 citations