Proteasome blockers inhibit protein breakdown in skeletal muscle after burn injury in rats

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin

1995 • 1,601 citations

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

1996 • 440 citations

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

1994 • 394 citations

Mechanistic Studies on the Inactivation of the Proteasome by Lactacystin

1996 • 370 citations

The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences.

1985 • 355 citations

Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

1996 • 347 citations

Proteasomes: protein degradation machines of the cell

1994 • 320 citations

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

1997 • 315 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma

1995 • 263 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle

1986 • 221 citations

Inhibitory Effect of di- and Tripeptidyl Aldehydes on Calpains and Cathepsins

1990 • 204 citations

Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy.

1991 • 122 citations

[10] In vitro preparations of the diaphragm and other skeletal muscles

1975 • 118 citations

Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.

1995 • 99 citations

Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors

1998 • 84 citations

Prosomes discriminate between mRNA of adenovirus‐infected and uninfected HeLa cells

1989 • 41 citations

Identification and Initial Characterization of a Specific Proteasome (Prosome) Associated RNase Activity

1995 • 40 citations

Branched-chain-amino-acid-preferring peptidase activity of the lobster multicatalytic proteinase (proteasome) and the degradation of myofibrillar proteins

1995 • 38 citations

Protein dynamics in skeletal muscle after trauma: local and systemic effects.

1986 • 35 citations

Metabolic Response to Burn Injury: Nutritional Implications.

1993 • 32 citations

The Metabolism of the Albino Rat During Prolonged Fasting at Two Different Environmental Temperatures

1930 • 31 citations