The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

1996 • 1,149 citations

Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

1983 • 1,105 citations

The N-end rule: functions, mysteries, uses.

1996 • 859 citations

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

1995 • 745 citations

THE UBIQUITIN-CONJUGATION SYSTEM

1992 • 561 citations

The multicatalytic and 26 S proteases.

1993 • 476 citations

Universality and Structure of the N-end Rule

1989 • 472 citations

The mechanism and functions of ATP‐dependent proteases in bacterial and animal cells

1992 • 450 citations

Ubiquitination

1991 • 430 citations

Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts

1996 • 429 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

1997 • 315 citations

"Covalent affinity" purification of ubiquitin-activating enzyme.

1982 • 310 citations

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

1995 • 294 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

1997 • 220 citations

Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.

1994 • 210 citations

Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity.

1993 • 208 citations

Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes.

1987 • 189 citations

Degradation of the Proto-Oncogene Product c-Fos by the Ubiquitin Proteolytic System In Vivo and In Vitro: Identification and Characterization of the Conjugating Enzymes

1995 • 167 citations

Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105

1995 • 150 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

Role of arginine-tRNA in protein degradation by the ubiquitin pathway

1987 • 142 citations

E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.

1996 • 141 citations

Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system

1987 • 132 citations

Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins

1992 • 131 citations

Transfer RNA is required for conjugation of ubiquitin to selective substrates of the ubiquitin- and ATP-dependent proteolytic system.

1986 • 77 citations

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway.

1988 • 75 citations

Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme.

1990 • 73 citations

Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-“N-end rule” protein substrates

1994 • 66 citations

Enzymes Catalyzing Ubiquitination and Proteolytic Processing of the p105 Precursor of Nuclear Factor κB1

1998 • 65 citations

Stable ester conjugate between the Saccharomyces cerevisiae RAD6 protein and ubiquitin has no biological activity

1991 • 58 citations

Uncoupling ubiquitin-protein conjugation from ubiquitin-dependent proteolysis by use of .beta.,.gamma.-nonhydrolyzable ATP analogs

1991 • 43 citations

Post-translational addition of an arginine moiety to acidic NH2 termini of proteins is required for their recognition by ubiquitin-protein ligase.

1990 • 40 citations

A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6.

1992 • 40 citations

Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system

1994 • 39 citations

Myology; Basic and Clinical

1989 • 39 citations

Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3

1996 • 38 citations

Regulation of the ubiquitin‐mediated proteolytic pathway: Role of the substrate α‐NH₂ group and of transfer RNA

1987 • 19 citations