What do we really know about the ubiquitin-proteasome pathway in muscle atrophy?

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

1994 • 2,480 citations

In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue

1986 • 1,942 citations

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

1998 • 1,483 citations

Proteasome inhibitors: valuable new tools for cell biologists

1998 • 1,453 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

SCF and Cullin/RING H2-Based Ubiquitin Ligases

1999 • 1,249 citations

The N-end rule: functions, mysteries, uses.

1996 • 859 citations

Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

1999 • 734 citations

A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes.

1977 • 553 citations

The Ubiquitin-Proteasome Pathway and Pathogenesis of Human Diseases

1999 • 459 citations

Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome

1997 • 451 citations

Ubiquitin in chains

2000 • 445 citations

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

1996 • 440 citations

Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts

1996 • 429 citations

Inactivation of the HR6B Ubiquitin-Conjugating DNA Repair Enzyme in Mice Causes Male Sterility Associated with Chromatin Modification

1996 • 402 citations

Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes.

1994 • 394 citations

The recognition component of the N-end rule pathway.

1990 • 388 citations

Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

1996 • 347 citations

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

1997 • 315 citations

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition.

1996 • 298 citations

Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy

1995 • 294 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Coordinate activation of lysosomal, Ca2+-activated and ATP-ubiquitin-dependent proteinases in the unweighted rat soleus muscle

1996 • 278 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Evaluation of signals activating ubiquitin-proteasome proteolysis in a model of muscle wasting

1999 • 240 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Muscle wasting in a rat model of long-lasting sepsis results from the activation of lysosomal, Ca2+ -activated, and ubiquitin-proteasome proteolytic pathways.

1996 • 222 citations

Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

1996 • 222 citations

Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle

1986 • 221 citations

Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.

1994 • 210 citations

A Predictive Scale for Evaluating Cyclin-dependent Kinase Substrates

1996 • 201 citations

Peptides accelerate their uptake by activating a ubiquitin-dependent proteolytic pathway

2000 • 198 citations

The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer

1999 • 192 citations

Sepsis stimulates release of myofilaments in skeletal muscle by a calcium‐dependent mechanism

1999 • 191 citations

Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats

1999 • 184 citations

The mouse and human genes encoding the recognition component of the N-end rule pathway

1998 • 175 citations

Activation of the ubiquitin pathway in rat skeletal muscle by catabolic doses of glucocorticoids

1997 • 157 citations

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

1998 • 155 citations

Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites.

1988 • 144 citations

The N-end Rule Pathway Catalyzes a Major Fraction of the Protein Degradation in Skeletal Muscle

1998 • 140 citations

Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

1994 • 135 citations

The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism

1986 • 122 citations

Adenosine transport in cultured human umbilical vein endothelial cells is reduced in diabetes

1994 • 108 citations

Muscle wasting associated with cancer cachexia is linked to an important activation of the atp‐dependent ubiquitin‐mediated proteolysis

1995 • 104 citations

Cell Cycle–regulated Proteolysis of Mitotic Target Proteins

1999 • 94 citations

Inhibition of the N-end rule pathway in living cells.

1991 • 90 citations

A Mouse Amidase Specific for N-terminal Asparagine

1996 • 81 citations

Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway.

1988 • 75 citations

Regulation of Components of the Ubiquitin System by Insulin-Like Growth Factor I and Growth Hormone in Skeletal Muscle of Rats Made Catabolic with Dexamethasone

1999 • 73 citations

The Gene Expression of Ubiquitin Ligase E3α Is Upregulated in Skeletal Muscle during Sepsis in Rats—Potential Role of Glucocorticoids

2000 • 55 citations

Isolation, Characterization, and Partial Purification of a Novel Ubiquitin-Protein Ligase, E3

1996 • 38 citations

Insulin Suppresses the Increased Activities of Lysosomal Cathepsins and Ubiquitin Conjugation System in Burn-Injured Rats

2000 • 26 citations

Regulation of Components of the Ubiquitin System by Insulin-Like Growth Factor I and Growth Hormone in Skeletal Muscle of Rats Made Catabolic with Dexamethasone

1999 • 17 citations