Intensive Insulin Therapy in Critically Ill Patients

Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)

1998 • 19,638 citations

Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation

1998 • 14,996 citations

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

APACHE II

1985 • 12,347 citations

Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis

2001 • 5,900 citations

Stress hyperglycaemia and increased risk of death after myocardial infarction in patients with and without diabetes: a systematic overview

2000 • 2,166 citations

Discrete sequential boundaries for clinical trials

1983 • 1,710 citations

Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study): Effects on mortality at 1 year

1995 • 1,586 citations

Discrete Sequential Boundaries for Clinical Trials

1983 • 1,584 citations

Acute Renal Failure

1996 • 1,377 citations

Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus

1997 • 1,297 citations

Therapeutic intervention scoring system

1974 • 1,203 citations

The Clinical Significance of Positive Blood Cultures in the 1990s: A Prospective Comprehensive Evaluation of the Microbiology, Epidemiology, and Outcome of Bacteremia and Fungemia in Adults

1997 • 1,159 citations

Stress-Induced Hyperglycemia

2001 • 1,138 citations

Immune dysfunction in patients with diabetes mellitus (DM)

1999 • 1,128 citations

Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial

2000 • 982 citations

INCREASED MORTALITY ASSOCIATED WITH GROWTH HORMONE TREATMENT IN CRITICALLY ILL ADULTS

1999 • 894 citations

Glycometabolic State at Admission: Important Risk Marker of Mortality in Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Infarction

1999 • 873 citations

Simplified Therapeutic Intervention Scoring System

1996 • 655 citations

Infection and diabetes: The case for glucose control

1982 • 640 citations

CRITICAL ILLNESS POLYNEUROPATHY

1987 • 533 citations

Alterations in carbohydrate metabolism during stress: A review of the literature

1995 • 509 citations

Lack of Renoprotective Effects of Dopamine and Furosemide during Cardiac Surgery

2000 • 477 citations

Effect of Severe Burn Injury on Substrate Cycling by Glucose and Fatty Acids

1987 • 455 citations

Glucose metabolism in man: Responses to intravenous glucose infusion

1979 • 375 citations

Sepsis and the systemic inflammatory response syndrome

1996 • 274 citations

Glucose Potassium Insulin Infusions in the Treatment of Acute Stroke Patients With Mild to Moderate Hyperglycemia

1999 • 271 citations

Insulin Infusion Improves Neutrophil Function in Diabetic Cardiac Surgery Patients

1999 • 250 citations

Atrial natriuretic factor in oliguric acute renal failure

2000 • 242 citations

Nutritional Support

1997 • 238 citations

A Submaximal Dose of Insulin Promotes Net Skeletal Muscle Protein Synthesis in Patients With Severe Burns

1999 • 232 citations

Reactivation of Pituitary Hormone Release and Metabolic Improvement by Infusion of Growth Hormone-Releasing Peptide and Thyrotropin-Releasing Hormone in Patients with Protracted Critical Illness1

1999 • 227 citations

Stress hormone and blood glucose response following acute stroke in the elderly.

1991 • 213 citations

Differentiation between septic and postburn insulin resistance

1989 • 187 citations

Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys.

1997 • 182 citations

Severe Early-Onset Polyneuropathy in Insulin-Dependent Diabetes Mellitus

1992 • 130 citations

Complications of coronary artery surgery in diabetic patients.

1991 • 129 citations

Reactivation of Pituitary Hormone Release and Metabolic Improvement by Infusion of Growth Hormone-Releasing Peptide and Thyrotropin-Releasing Hormone in Patients with Protracted Critical Illness

1999 • 92 citations

The Axonopathy of Diabetic Neuropathy

1982 • 85 citations

Critical illness polyneuropathy a review of the literature, definition and pathophysiology

1994 • 80 citations

Clinical Importance of Identifying Coagulase-Negative Staphylococci Isolated from Blood Cultures: Evaluation of MicroScan Rapid and Dried Overnight Gram-Positive Panels versus a Conventional Reference Method

1998 • 75 citations

HOSPITAL MANAGEMENT OF DIABETES

2000 • 74 citations

Glucose modulates hemodynamic, metabolic, and inflammatory responses to lipopolysaccharide in rabbits

1997 • 73 citations

A Paradoxical Gender Dissociation within the Growth Hormone/Insulin-Like Growth Factor I Axis during Protracted Critical Illness

2000 • 50 citations

Diabetes-Induced cholestasis in the rat: Possible role of hyperglycemia and hypoinsulinemia

1988 • 39 citations

Outcome of pregnancy in diabetic women in northeast England and in Norway, 1994-7

2000 • 38 citations

Insulin's effect on bile flow and lipid excretion during euglycemia and hypoglycemia

1984 • 18 citations

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