IGF-I stimulates protein synthesis but does not inhibit protein breakdown in muscle from septic rats

Effect of sepsis on tissue adenine nucleotide levels.

1979 • 329 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscles

1986 • 189 citations

Impaired actions of insulin-like growth factor 1 on protein Synthesis and degradation in skeletal muscle of rats with chronic renal failure. Evidence for a postreceptor defect.

1996 • 173 citations

Sepsis-induced changes in protein synthesis: differential effects on fast- and slow-twitch muscles

1992 • 157 citations

Total and myofibrillar protein breakdown in different types of rat skeletal muscle: Effects of sepsis and regulation by insulin

1989 • 147 citations

Insulin-Like Growth Factor-1 Lowers Protein Oxidation in Patients with Thermal Injury

1994 • 135 citations

Phosphatidylinositol 3-kinase and p70 s6 kinase participate in the regulation of protein turnover in skeletal muscle by insulin and insulin-like growth factor I.

1996 • 119 citations

[10] In vitro preparations of the diaphragm and other skeletal muscles

1975 • 118 citations

Insulin-like growth factor-1 and insulin resistance in skeletal muscles of adult and old rats

1994 • 111 citations

Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.

1995 • 99 citations

Impaired metabolic response to recombinant insulin-like growth factor-1 in dialysis patients

1995 • 79 citations

Insulin-like growth factor I accelerates protein synthesis in skeletal muscle during sepsis

1995 • 74 citations

Effect of Insulin on Amino Acid Uptake and Protein Turnover in Skeletal Muscle From Septic Rats

1987 • 58 citations

Insulin-like growth factor I stimulates degradation of an mRNA transcript encoding the 14 kDa ubiquitin-conjugating enzyme

1996 • 57 citations

Insulin‐Like Growth Factor 1 Stimulates Protein Synthesis and Inhibits Protein Breakdown in Muscle From Burned Rats

1997 • 54 citations

Repeated Administration of Recombinant Human Insulin-Like Growth Factor-I in Patients After Gastric Surgery

1995 • 52 citations

Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats.

1989 • 52 citations

Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length

1990 • 48 citations

Regulation of Protein Turnover by Recombinant Human Insulin-Like Growth Factor-I in L6 Myotube Cultures

1988 • 46 citations

Clinical review 59: Uses of human insulin-like growth factor-I in clinical conditions.

1994 • 44 citations

Effects of serum and insulin-like growth factor I on protein degradation and protease gene expression in rat L8 myotubes

1994 • 44 citations

The effect of recombinant human IGF‐I on protein metabolism in post‐operative patients without nutrition compared to effects in experimental animals

1995 • 42 citations

Influence of sepsis in rats on muscle protein turnover in vivo and in tissue incubated under different in vitro conditions

1991 • 34 citations

Effect of postoperative insulin-like growth factor I supplementation on protein metabolism in humans

1995 • 25 citations

Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats

1992 • 25 citations