A family of human cdc2-related protein kinases.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing

1984 • 4,231 citations

Specific Enzymatic Amplification of DNA In Vitro: The Polymerase Chain Reaction

1986 • 3,400 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Cyclin is degraded by the ubiquitin pathway

1991 • 2,355 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Cyclin A is required at two points in the human cell cycle.

1992 • 1,380 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Tyrosine phosphorylation of the fission yeast cdc2+ protein kinase regulates entry into mitosis

1989 • 1,237 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Dominoes and Clocks: the Union of Two Views of the Cell Cycle

1989 • 750 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Human D-type cyclin

1991 • 712 citations

An Insulin-Stimulated Protein Kinase Similar to Yeast Kinases Involved in Cell Cycle Control

1990 • 701 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

1990 • 660 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

1988 • 563 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins

1991 • 509 citations

Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates.

1991 • 502 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae

1991 • 463 citations

Role of phosphorylation in p34cdc2 activation: identification of an activating kinase.

1992 • 459 citations

Phosphorylation at Thr167 is required for Schizosaccharomyces pombe p34cdc2 function.

1991 • 459 citations

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

1988 • 445 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Differential phosphorylation of vertebrate p34cdc2 kinase at the G1/S and G2/M transitions of the cell cycle: identification of major phosphorylation sites.

1991 • 439 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

THE SELECTION OF S. CEREVISIAE MUTANTS DEFECTIVE IN THE START EVENT OF CELL DIVISION

1980 • 391 citations

Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation

1990 • 364 citations

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

1987 • 341 citations

cdc2 phosphorylation is required for its interaction with cyclin.

1991 • 338 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Mutations of p34cdc2 phosphorylation sites induce premature mitotic events in HeLa cells: evidence for a double block to p34cdc2 kinase activation in vertebrates.

1991 • 318 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

1992 • 290 citations

Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiae

1973 • 278 citations

Phosphorylation of RNA polymerase by the murine homologue of the cell-cycle control protein cdc2

1989 • 270 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

Maturation promoting factor, cyclin and the control of M-phase

1989 • 260 citations

Parallel activation of the NIMA and p34cdc2 cell cycle-regulated protein kinases is required to initiate mitosis in A. nidulans

1991 • 243 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

A bifunctional gene product involved in two phases of the yeast cell cycle

1982 • 225 citations

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

1991 • 225 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

Isolation and characterization of cDNA clones encoding a functional p34cdc2 homologue from Zea mays.

1991 • 201 citations

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

1991 • 201 citations

p34cdc2: the S and M kinase?

1990 • 192 citations

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

1987 • 191 citations

Complementation of a yeast cell cycle mutant by an alfalfa cDNA encoding a protein kinase homologous to p34cdc2.

1991 • 187 citations

Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.

1990 • 181 citations

Drosophila cdc2 homologs: a functional homolog is coexpressed with a cognate variant.

1990 • 178 citations

CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae.

1991 • 170 citations

Identification of two cell-cycle-controlling cdc2 gene homologs in Arabidopsis thaliana

1991 • 150 citations

Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.

1990 • 149 citations

Complementation of fission yeast cdc2ts and cdc25ts mutants identifies two cell cycle genes from Drosophila: a cdc2 homologue and string.

1990 • 139 citations

DAF1, a Mutant Gene Affecting Size Control, Pheromone Arrest, and Cell Cycle Kinetics of Saccharomyces cerevisiae

1988 • 130 citations

A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis.

1990 • 121 citations

Molecular cloning of the human casein kinase II .alpha. subunit

1989 • 108 citations

Structure and developmental expression of the chicken CDC2 kinase.

1989 • 103 citations

p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

1990 • 99 citations

KIN28, a yeast split gene coding for a putative protein kinase homologous to CDC28.

1986 • 96 citations

Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.

1992 • 84 citations

SGV1 encodes a CDC28/cdc2-related kinase required for a Gα subunit-mediated adaptive response to pheromone in S. cerevisiae

1991 • 79 citations

Negative regulators of the PHO system inSaccharomyces cerevisiae: isolation and structural characterization ofPHO85

1987 • 74 citations

Isolation of a cDNA Clone Coding for the γ-Subunit of Mouse Nerve Growth Factor Using a High-Stringency Selection Procedure

1984 • 51 citations

Cloning of the peacdc2 homologue by efficient immunological screening of PCR products

1991 • 46 citations

A Novel Mammalian Protein Kinase Gene (mak) Is Highly Expressed in Testicular Germ Cells at and after Meiosis

1990 • 30 citations