Identification of G₁ Kinase Activity for cdk6, a Novel Cyclin D Partner

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Universal control mechanism regulating onset of M-phase

1990 • 2,882 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

1993 • 1,605 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

A novel cyclin encoded by a bcl1-linked candidate oncogene

1991 • 1,286 citations

Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4

1993 • 1,258 citations

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

1991 • 1,190 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

Overexpression of mouse D-type cyclins accelerates G1 phase in rodent fibroblasts.

1993 • 1,057 citations

Functional interactions of the retinoblastoma protein with mammalian D-type cyclins

1993 • 1,047 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

Regulation of retinoblastoma protein functions by ectopic expression of human cyclins

1992 • 1,031 citations

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

1992 • 1,023 citations

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

1989 • 990 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

A family of human cdc2-related protein kinases.

1992 • 928 citations

Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins

1992 • 906 citations

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

1991 • 846 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Physical interaction of the retinoblastoma protein with human D cyclins

1993 • 780 citations

Human D-type cyclin

1991 • 712 citations

Cyclin activation of p34cdc2

1990 • 690 citations

Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family

1991 • 656 citations

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F

1992 • 652 citations

TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest

1993 • 544 citations

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1991 • 541 citations

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

1993 • 514 citations

SV40 large T antigen binds preferentially to an underphosphorylated member of the retinoblastoma susceptibility gene product family

1989 • 508 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase

1991 • 475 citations

Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product

1989 • 457 citations

Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system

1993 • 453 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

1993 • 362 citations

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.

1991 • 343 citations

Human cyclin-dependent kinase 2 is activated during the S and G2 phases of the cell cycle and associates with cyclin A.

1992 • 331 citations

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

1993 • 325 citations

D-Type Cyclin-Dependent Kinase Activity in Mammalian Cells

1994 • 322 citations

Retinoblastoma cancer suppressor gene product is a substrate of the cell cycle regulator cdc2 kinase.

1991 • 304 citations

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

1992 • 277 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.

1991 • 265 citations

Independent regulation of human D-type cyclin gene expression during G1 phase in primary human T lymphocytes.

1993 • 247 citations

The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression.

1992 • 239 citations

Association of cdk2 Kinase with the Transcription Factor E2F During S Phase

1992 • 239 citations

Inhibition of granulocyte differentiation by G1 cyclins D2 and D3 but not D1.

1993 • 233 citations

Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2.

1992 • 230 citations

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

1991 • 225 citations

The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product

1990 • 222 citations

cdc2 Gene Expression at the G ₁ to S Transition in Human T Lymphocytes

1990 • 220 citations

Phosphorylation of the retinoblastoma protein by cdk2.

1992 • 217 citations

Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation.

1991 • 201 citations

Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family.

1987 • 191 citations

Regulation of G1/S transition by cyclins D2 and D3 in hematopoietic cells.

1993 • 179 citations

Cloning and characterization of human cyclin D3, a cDNA closely related in sequence to the PRAD1/cyclin D1 proto-oncogene.

1992 • 150 citations

Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle.

1990 • 149 citations

p40MO15, a cdc2-related protein kinase involved in negative regulation of meiotic maturation of Xenopus oocytes.

1990 • 99 citations

In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase

1989 • 98 citations

Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis.

1992 • 84 citations

Cloning of a D-type cyclin from murine erythroleukemia cells.

1992 • 64 citations

The Cyclin-dependent Kinase Family

1991 • 28 citations