Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

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1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

NMR with Proteins and Nucleic Acids

1986 • 7,896 citations

NMR of Proteins and Nucleic Acids

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AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm

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Pure absorption gradient enhanced heteronuclear single quantum correlation spectroscopy with improved sensitivity

1992 • 2,231 citations

Engineering green fluorescent protein for improved brightness, longer wavelengths and fluorescence resonance energy transfer

1996 • 1,462 citations

Rho GTPases Control Polarity, Protrusion, and Adhesion during Cell Movement

1999 • 1,452 citations

Coupling of folding and binding for unstructured proteins

2002 • 1,307 citations

Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ

2001 • 1,004 citations

On the treatment of negative intensity observations

1978 • 964 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Fluorescence resonance energy transfer

1995 • 878 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

Autoinhibition and activation mechanisms of the Wiskott–Aldrich syndrome protein

2000 • 739 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

Structure of PAK1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch

2000 • 515 citations

[13] Fluorescence resonance energy transfer

1995 • 513 citations

Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

2001 • 426 citations

Intercellular junctions and cellular polarity: the PAR–aPKC complex, a conserved core cassette playing fundamental roles in cell polarity

2001 • 421 citations

DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila

2000 • 405 citations

Structure of Cdc42 in complex with the GTPase-binding domain of the ‘Wiskott–Aldrich syndrome’ protein

1999 • 319 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

PAR‐6 regulates aPKC activity in a novel way and mediates cell‐cell contact‐induced formation of the epithelial junctional complex

2001 • 300 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

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Miscellaneous Algorithms for Density Modification

1998 • 286 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

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par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 • 222 citations

Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

1998 • 198 citations

Assembly of Epithelial Tight Junctions Is Negatively Regulated by Par6

2002 • 188 citations

Structure of Cdc42 bound to the GTPase binding domain of PAK.

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C-terminal binding domain of Rho GDP-dissociation inhibitor directs N-terminal inhibitory peptide to GTPases

1997 • 169 citations

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

1999 • 162 citations

PDZ domain proteins: Scaffolds for signaling complexes

1997 • 161 citations

CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

2001 • 154 citations

Conformational Switch and Role of Phosphorylation in PAK Activation

2001 • 104 citations

Bazooka and PAR-6 are required with PAR-1 for the maintenance of oocyte fate in Drosophila

2001 • 87 citations

Residues in Cdc42 That Specify Binding to Individual CRIB Effector Proteins

2000 • 68 citations

Density modification: theory and practice

2001 • 7 citations