A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Role of Phosphoinositide 3-OH Kinase in Cell Transformation and Control of the Actin Cytoskeleton by Ras

1997 • 1,064 citations

Origins of Cell Polarity

1996 • 1,024 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Small GTP-Binding Proteins and the Regulation of the Actin Cytoskeleton

1994 • 822 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Activation of Rac1, RhoA, and Mitogen-Activated Protein Kinases Is Required for Ras Transformation

1995 • 683 citations

Regulation of protein kinase C ζ by PI 3-kinase and PDK-1

1998 • 612 citations

Determination of the Specific Substrate Sequence Motifs of Protein Kinase C Isozymes

1997 • 557 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts

1999 • 450 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts

1999 • 375 citations

Activation of IκB Kinase β by Protein Kinase C Isoforms

1999 • 366 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

1998 • 356 citations

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

1998 • 352 citations

Structural and Functional Regulation of Tight Junctions by RhoA and Rac1 Small GTPases

1998 • 349 citations

Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells

1999 • 340 citations

Cdc42 Regulates Anchorage-Independent Growth and Is Necessary for Ras Transformation

1997 • 312 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

1995 • 271 citations

Regulation of Cadherin Function by Rho and Rac: Modulation by Junction Maturation and Cellular Context

1999 • 257 citations

Cell proliferation and apoptosis

1999 • 235 citations

Control of spindle orientation in Drosophila by the Par-3-related PDZ-domain protein Bazooka

1998 • 233 citations

A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation

1993 • 223 citations

Intracellular signalling: PDK1 – a kinase at the hub of things

1999 • 221 citations

A novel Cdc42Hs mutant induces cellular transformation

1997 • 213 citations

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

1998 • 187 citations

The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction with the PDZ domain of cellular proteins

1998 • 184 citations

Suppression of Ras-Induced Apoptosis by the Rac GTPase

1999 • 177 citations

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo

1996 • 149 citations

Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts

1999 • 143 citations

Evidence That Atypical Protein Kinase C-λ and Atypical Protein Kinase C-ζ Participate in Ras-mediated Reorganization of the F-actin Cytoskeleton

1999 • 138 citations

The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression

1999 • 116 citations

A Role for Rho-like GTPases in the Polarisation of Mouse Eight-Cell Blastomeres

1999 • 102 citations

Rac and Cdc42 Are Potent Stimulators of E2F-dependent Transcription Capable of Promoting Retinoblastoma Susceptibility Gene Product Hyperphosphorylation

1998 • 78 citations

Genetics: A touch of elegance with RNAi

1999 • 75 citations

Protein kinase C: Ports of anchor in the cell

1996 • 67 citations

Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-κB dependent pathway

1999 • 64 citations

Selective Alterations in Biosynthetic and Endocytic Protein Traffic in Madin-Darby Canine Kidney Epithelial Cells Expressing Mutants of the Small GTPase Rac1

2000 • 63 citations

CDC42 and FGD1 Cause Distinct Signaling and Transforming Activities

1998 • 61 citations

Transformation Activity of Cdc42 Requires a Region Unique to Rho-related Proteins

1998 • 46 citations

Rac regulates the stability of the adherens junction and its components, thus affecting epithelial cell differentiation and transformation

1999 • 40 citations

Dual role of Ras and Rho proteins: At the cutting edge of life and death

1998 • 39 citations

Overexpression of Mammalian Protein Kinase C-ζ Does Not Affect the Growth Characteristics of NIH 3T3 Cells

1995 • 24 citations

Cell polarity: Par for the polar course

1997 • 20 citations

Rac and Cdc42 Effectors

1999 • 17 citations

Identification and developmental expression of par-6 gene in Xenopus laevis

2000 • 17 citations