CDC-42 regulates PAR protein localization and function to control cellular and embryonic polarity in C. elegans

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

1998 • 14,674 citations

THE GENETICS OF CAENORHABDITIS ELEGANS

1974 • 14,589 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

C. Elegans II

1998 • 1,072 citations

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

2000 • 913 citations

Identification of genes required for cytoplasmic localization in early C. elegans embryos

1988 • 841 citations

A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity

2000 • 740 citations

Regulation of Cell–Cell Adhesion by Rac and Rho Small G Proteins in MDCK Cells

1997 • 555 citations

Cdc42: An Essential Rho-Type GTPase Controlling Eukaryotic Cell Polarity

1999 • 546 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryos

1995 • 407 citations

Cyk-4

2000 • 386 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish

2000 • 301 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

A human homolog of the C. elegans polarity determinant Par-6 links Rac and Cdc42 to PKCζ signaling and cell transformation

2000 • 276 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos

1996 • 254 citations

CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 • 222 citations

Polarization of the anterior–posterior axis of C. elegans is a microtubule-directed process

2000 • 177 citations

EARLY PATTERNING OF THE C. ELEGANS EMBRYO

1998 • 173 citations

Fluorescence visualization of the distribution of microfilaments in gonads and early embryos of the nematode Caenorhabditis elegans.

1986 • 167 citations

Chapter 13 Blastomere Culture and Analysis

1995 • 151 citations

The coronin-like protein POD-1 is required for anterior-posterior axis formation and cellular architecture in the nematode Caenorhabditis elegans

1999 • 140 citations

Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.

1995 • 134 citations

An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotes

1988 • 131 citations

Functional Analysis of Cdc42 in Actin Filament Assembly, Epithelial Morphogenesis, and Cell Signaling during Drosophila Development

2000 • 117 citations

Genetic Requirements for PIE-1 Localization and Inhibition of Gene Expression in the Embryonic Germ Lineage ofCaenorhabditis elegans

1998 • 102 citations

3 Maternal Control of Pattern Formation in Early Caenorhabditis elegans Embryos

1998 • 102 citations

Brief cytochalasin-induced disruption of microfilaments during a critical interval in 1-cell C. elegans embryos alters the partitioning of developmental instructions to the 2-cell embryo

1990 • 100 citations

Fertilization and Establishment of Polarity in the Embryo

1997 • 98 citations

par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifs.

1994 • 87 citations

The let-99 gene is required for proper spindle orientation during cleavage of the C. elegans embryo

1998 • 70 citations

The Caenorhabditis elegans p21-activated Kinase (CePAK) Colocalizes with CeRac1 and CDC42Ce at Hypodermal Cell Boundaries during Embryo Elongation

1996 • 61 citations

The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation

1993 • 61 citations

Caenorhabditis Elegans

2014 • 3 citations