Atypical Protein Kinase C Is Involved in the Evolutionarily Conserved Par Protein Complex and Plays a Critical Role in Establishing Epithelia-Specific Junctional Structures

Improved method for high efficiency transformation of intact yeast cells

1992 • 3,258 citations

Occludin: a novel integral membrane protein localizing at tight junctions.

1993 • 2,466 citations

Signalling through the lipid products of phosphoinositide-3-OH kinase

1997 • 1,314 citations

Protein kinase C isoenzymes: divergence in signal transduction?

1993 • 1,237 citations

Origins of Cell Polarity

1996 • 1,024 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

1996 • 849 citations

Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full-length virus genome.

1996 • 804 citations

CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice

1999 • 678 citations

A Conserved Binding Motif Defines Numerous Candidate Target Proteins for Both Cdc42 and Rac GTPases

1995 • 625 citations

A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 • 510 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

Drosophila Atypical Protein Kinase C Associates with Bazooka and Controls Polarity of Epithelia and Neuroblasts

2000 • 467 citations

The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

1986 • 446 citations

Novel function of the cell adhesion molecule uvomorulin as an inducer of cell surface polarity

1990 • 444 citations

Claudin-11/OSP-based Tight Junctions of Myelin Sheaths in Brain and Sertoli Cells in Testis

1999 • 434 citations

Protein kinase C ζ isoform is critical for mitogenic signal transduction

1993 • 383 citations

Assembly of the tight junction: the role of diacylglycerol.

1993 • 381 citations

Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis elegans

1998 • 377 citations

The Product of par-4, a Gene Induced during Apoptosis, Interacts Selectively with the Atypical Isoforms of Protein Kinase C

1996 • 367 citations

Requirement of Atypical Protein Kinase Cλ for Insulin Stimulation of Glucose Uptake but Not for Akt Activation in 3T3-L1 Adipocytes

1998 • 365 citations

PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos

1999 • 293 citations

Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells

1992 • 280 citations

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3

1996 • 271 citations

EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase.

1996 • 270 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.

1994 • 236 citations

Localization of Atypical Protein Kinase C Isoforms into Lysosome-Targeted Endosomes through Interaction with p62

1998 • 230 citations

The polarized distribution of an apical cell surface glycoprotein is maintained by interactions with the cytoskeleton of Madin-Darby canine kidney cells.

1988 • 209 citations

Mammalian alpha 1- and beta 1-syntrophin bind to the alternative splice-prone region of the dystrophin COOH terminus.

1995 • 164 citations

Mutations in the par genes of Caenorhabditis elegans affect cytoplasmic reorganization during the first cell cycle

1990 • 158 citations

Molecular genetics of asymmetric cleavage in the early Caenorhabditis elegans embryo

1996 • 149 citations

Evidence That Atypical Protein Kinase C-λ and Atypical Protein Kinase C-ζ Participate in Ras-mediated Reorganization of the F-actin Cytoskeleton

1999 • 138 citations

Involvement of a Heterotrimeric G Protein α Subunit in Tight Junction Biogenesis

1996 • 136 citations

Critical role for intracellular calcium in tight junction biogenesis

1994 • 127 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

Ras-dependent signal transduction is indispensable but not sufficient for the activation of AP1/Jun by PKC delta.

1994 • 111 citations

Structure and properties of a ubiquitously expressed protein kinase C, nPKCδ

1991 • 105 citations

Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss

2000 • 85 citations

UCN‐01, an anti‐tumor drug, is a selective inhibitor of the conventional PKC subfamily

1995 • 78 citations

[18] Expression, separation, and assay of protein kinase C subspecies

1991 • 25 citations