4‐1BB stimulation inhibits allergen‐specific immunoglobulin E production and airway hyper‐reactivity but partially suppresses bronchial eosinophilic inflammation in a mouse asthma model

ICOS co-stimulatory receptor is essential for T-cell activation and function

2001 • 902 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Cutting Edge: 4-1BB Is a Bona Fide CD8 T Cell Survival Signal

1999 • 379 citations

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma

1997 • 373 citations

Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.

1997 • 275 citations

ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

2001 • 273 citations

Temporal Segregation of 4-1BB Versus CD28-Mediated Costimulation: 4-1BB Ligand Influences T Cell Numbers Late in the Primary Response and Regulates the Size of the T Cell Memory Response Following Influenza Infection

2002 • 270 citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.

1997 • 269 citations

Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness

1997 • 251 citations

OX40 (CD134) Controls Memory T Helper 2 Cells that Drive Lung Inflammation

2003 • 244 citations

T Cell Death and Transplantation Tolerance

2001 • 218 citations

Development of Allergic Inflammation in a Murine Model of Asthma Is Dependent on the Costimulatory Receptor Ox40

2001 • 204 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

2002 • 178 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 174 citations

Gene therapy for cancer using single-chain Fv fragments specific for 4-1BB

2002 • 162 citations

CD137 costimulatory T cell receptor engagement reverses acute disease in lupus-prone NZB × NZW F1 mice

2003 • 152 citations

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

1997 • 133 citations

Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease

2001 • 127 citations

CD80 Costimulation Is Essential for the Induction of Airway Eosinophilia

1997 • 120 citations

4-1BB (CD137) controls the clonal expansion and survival of CD8 T cellsin vivo but does not contribute to the development of cytotoxicity

2002 • 117 citations

Costimulatory molecule OX40L is critical for both Th1 and Th2 responses in allergic inflammation

2002 • 108 citations

Murine CTLA4-IgG Treatment Inhibits Airway Eosinophilia and Hyperresponsiveness and Attenuates IgE Upregulation in a Murine Model of Allergic Asthma

1997 • 92 citations

Disruption of antigen-induced inflammatory responses in CD40 ligand knockout mice.

1998 • 78 citations

Cigarette Smoke-induced Airway Hyperresponsiveness Is Not Dependent on Elevated Immunoglobulin and Eosinophilic Inflammation in a Mouse Model of Allergic Airway Disease

2002 • 67 citations

Blocking 4-1BB/4-1BB Ligand Interactions Prevents Herpetic Stromal Keratitis

2003 • 60 citations

IL-12-Dependent Vascular Cell Adhesion Molecule-1 Expression Contributes to Airway Eosinophilic Inflammation in a Mouse Model of Asthma-Like Reaction

2001 • 52 citations

Expression of tumour necrosis factor (TNF) ligand superfamily co‐stimulatory molecules CD30L, CD27L, OX40L, and 4‐1BBL in murine hearts with acute myocarditis caused by Coxsackievirus B3

2001 • 50 citations

CD40L, but Not CD40, Is Required for Allergen-Induced Bronchial Hyperresponsiveness in Mice

2000 • 49 citations

Ovalbumin aerosols induce airway hyperreactivity in naïve DO11.10 T cell receptor transgenic mice without pulmonary eosinophilia or OVA-specific antibody

2001 • 39 citations

Intrinsic AHR in IL-5 transgenic mice is dependent on CD4⁺cells and CD49d-mediated signaling

2001 • 16 citations