T Cell Death and Transplantation Tolerance

Immunobiology of Dendritic Cells

2000 • 6,653 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Induction of tolerance by IL-10-treated dendritic cells.

1997 • 1,263 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

"Infectious" Transplantation Tolerance

1993 • 890 citations

Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts

1984 • 767 citations

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1999 • 762 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Biochemical Mechanisms of IL-2–Regulated Fas-Mediated T Cell Apoptosis

1998 • 644 citations

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance

1999 • 621 citations

Fundamental Immunology

1990 • 607 citations

CD28-B7 blockade after alloantigenic challenge in vivo inhibits Th1 cytokines but spares Th2.

1995 • 532 citations

Quantifying the Frequency of Alloreactive T Cells In Vivo: New Answers to an Old Question

2001 • 519 citations

Identification of a previously unknown antigen-specific regulatory T cell and its mechanism of suppression

2000 • 448 citations

Immunologic ‘ignorance’ of vascularized organ transplants in the absence of secondary lymphoid tissue

2000 • 446 citations

The Interleukin-2 Receptor γ Chain: Its Role in the Multiple Cytokine Receptor Complexes and T Cell Development in XSCID

1996 • 411 citations

CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance

1996 • 394 citations

Anergic T Cells as Suppressor Cells in Vitro

1994 • 389 citations

Extrathymic T Cell Deletion and Allogeneic Stem Cell Engraftment Induced with Costimulatory Blockade Is Followed by Central T Cell Tolerance

1998 • 352 citations

IL-15 and IL-2: a matter of life and death for T cells in vivo

2001 • 316 citations

IFN-gamma is critical for long-term allograft survival induced by blocking the CD28 and CD40 ligand T cell costimulation pathways.

1998 • 275 citations

Regulatory T cells and inflammatory bowel disease

1999 • 270 citations

Normal clonal expansion but impaired Fasmediated cell death and anergy induction in interleukin‐2‐deficient mice

1995 • 234 citations

HOW DO MONOCLONAL ANTIBODIES INDUCE TOLERANCE? A Role for Infectious Tolerance?

1998 • 223 citations

Antiinflammatory Effects of CD95 Ligand (FasL)-induced Apoptosis

1998 • 220 citations

IFN-γ Is Critical for Long-Term Allograft Survival Induced by Blocking the CD28 and CD40 Ligand T Cell Costimulation Pathways

1998 • 211 citations

Impaired Alloantigen-Mediated T Cell Apoptosis and Failure To Induce Long-Term Allograft Survival in IL-2-Deficient Mice

1998 • 178 citations

CD8+TCR+ and CD8+TCR− Cells in Whole Bone Marrow Facilitate the Engraftment of Hematopoietic Stem Cells across Allogeneic Barriers

1999 • 177 citations

Linked suppression of skin graft rejection can operate through indirect recognition.

1998 • 175 citations

Anergic T Cells Inhibit the Antigen-Presenting Function of Dendritic Cells

2000 • 173 citations

ARE Th2 HELPER T LYMPHOCYTES BENEFICIAL, DELETERIOUS, OR IRRELEVANT IN PROMOTING ALLOGRAFT SURVIVAL?1

1997 • 170 citations

The Common Cytokine Receptor γ Chain Plays an Essential Role in Regulating Lymphoid Homeostasis

1997 • 168 citations

Mechanisms in CD4 antibody‐mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells

1994 • 167 citations

T cell regulation in adult transplantation tolerance.

1996 • 144 citations

Cutting Edge: Linked Suppression of Skin Graft Rejection Can Operate Through Indirect Recognition

1998 • 138 citations

On Histocompatibility Barriers, Th1 to Th2 Immune Deviation, and the Nature of the Allograft Responses

1998 • 122 citations

Immunity or tolerance: Opposite outcomes of microchimerism from skin grafts

2001 • 119 citations

Peripheral Deletion After Bone Marrow Transplantation with Costimulatory Blockade Has Features of Both Activation-Induced Cell Death and Passive Cell Death

2001 • 117 citations

An essential role for Fas ligand in transplantation tolerance induced by donor bone marrow

1998 • 108 citations

Anti-Third Party CD8+ CTLs as Potent Veto Cells

2000 • 100 citations

Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment.

1997 • 98 citations

The role of the common cytokine receptor gamma-chain in regulating IL-2-dependent, activation-induced CD8+ T cell death.

1999 • 87 citations

Evidence for Immune Regulation in the Induction of Transplantation Tolerance: A Conditional but Limited Role for IL-4

1999 • 86 citations

Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse

1999 • 84 citations

The Role of the Common Cytokine Receptor γ-Chain in Regulating IL-2-Dependent, Activation-Induced CD8+ T Cell Death

1999 • 67 citations

CD4-positive suppressor cells block allotransplant rejection.

1995 • 53 citations

Peripheral Immune Tolerance Blocks Clonal Expansion but Fails to Prevent the Differentiation of Th1 Cells

1998 • 49 citations

IL-4 expression by grafts from transgenic mice fails to prevent allograft rejection.

1997 • 42 citations

DEVELOPMENT OF SUPPRESSOR LYMPHOCYTES DURING ACUTE REJECTION OF RAT CARDIAC ALLOGRAFTS AND PRESERVATION OF SUPPRESSION BY ANTI-IL-2-RECEPTOR MONOCLONAL ANTIBODY

1986 • 26 citations

The role of clonal anergy in the avoidance of autoimmunity: inactivation of autocrine growth without loss of effector function

1998 • 23 citations

Interleukin‐2 Receptor‐Directed Immunosuppressive Therapies: Antibody‐ or Cytokine‐Based Targeting Molecules

1992 • 20 citations

The role of apoptosis in the induction and maintenance of tolerance

2001 • 6 citations

Interleukin-2 Receptor Directed Immunosuppressive Therapy

1987 • 5 citations