Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

1991 • 1,185 citations

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

1997 • 886 citations

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

1997 • 777 citations

Treatment of Murine Lupus with CTLA4Ig

1994 • 683 citations

Etiopathogenesis of Murine SLE¹

1981 • 517 citations

Aberrant transcription caused by the insertion of an early transposable element in an intron of the Fas antigen gene of lpr mice.

1993 • 506 citations

Reactive Oxygen Species Regulate Activation-Induced T Cell Apoptosis

1999 • 485 citations

Inducible T cell antigen 4-1BB. Analysis of expression and function.

1993 • 416 citations

Interaction between CD40 and its ligand gp39 in the development of murine lupus nephritis.

1995 • 371 citations

NK1.1 Cells Express 4-1BB (CDw137) Costimulatory Molecule and Are Required for Tumor Immunity Elicited by Anti-4-1BB Monoclonal Antibodies

1998 • 361 citations

Interferon-gamma is required for lupus-like disease and lymphoaccumulation in MRL-lpr mice.

1998 • 354 citations

Molecular cloning of a ligand for the inducible T cell gene 4‐1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor

1993 • 328 citations

Role of 4-1BB in immune responses

1998 • 312 citations

Roles of interferon-gamma and interleukin-4 in murine lupus.

1997 • 301 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 265 citations

IFN-gamma is essential for the development of autoimmune glomerulonephritis in MRL/Ipr mice.

1997 • 254 citations

IFN-gamma receptor signaling is essential for the initiation, acceleration, and destruction of autoimmune kidney disease in MRL-Fas(lpr) mice.

1998 • 247 citations

Moslecular and biological characterization of human 4‐1BB and its ligands

1994 • 242 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 225 citations

4‐1BB T‐cell antigen binds to mature B cells and macrophages, and costimulates anti‐μ‐primed splenic B cells

1994 • 223 citations

Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors

2002 • 215 citations

The regulation of T cell homeostasis and autoimmunity by T cell–derived LIGHT

2001 • 213 citations

Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function

1998 • 202 citations

IFN-γ Receptor Signaling Is Essential for the Initiation, Acceleration, and Destruction of Autoimmune Kidney Disease in MRL-FaslprMice

1998 • 202 citations

In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses

2002 • 195 citations

Administration of Agonistic Anti-4-1BB Monoclonal Antibody Leads to the Amelioration of Experimental Autoimmune Encephalomyelitis

2002 • 193 citations

Anti–4-1bb Monoclonal Antibodies Abrogate T Cell–Dependent Humoral Immune Responses in Vivo through the Induction of Helper T Cell Anergy

1999 • 184 citations

Treatment of murine lupus with cDNA encoding IFN-γR/Fc

2000 • 162 citations

Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis.

1988 • 154 citations

Antigen-Specific Therapy of Murine Lupus Nephritis Using Nucleosomal Peptides: Tolerance Spreading Impairs Pathogenic Function of Autoimmune T and B Cells

1999 • 150 citations

Ligation of 4-1BB (CDw137) Regulates Graft-Versus-Host Disease, Graft-Versus-Leukemia, and Graft Rejection in Allogeneic Bone Marrow Transplant Recipients

2001 • 147 citations

The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.

1984 • 128 citations

Tumour necrosis factor and other cytokines in murine lupus

1999 • 87 citations

Nitric Oxide Synthase Plays a Signaling Role in TCR-Triggered Apoptotic Death

1998 • 84 citations

Cytokines in the pathogenesis of systemic lupus erythematosus.

1999 • 82 citations

Nitric Oxide and Apoptosis

1997 • 73 citations

4-1BB: Still in the Midst of Darkness

2000 • 68 citations

Why do defects in the Fas-Fas ligand system cause autoimmunity?

1997 • 56 citations

Dichotomic effects of IFN-γ on the development of systemic lupus erythematosus-like syndrome in MRL-lpr / lpr mice

2000 • 50 citations

Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lprLupus

2000 • 45 citations

T cells in the pathogenesis of systemic lupus erythematosus

2001 • 37 citations

Treatment of murine lupus with anti-CD4 monoclonal antibodies.

1993 • 26 citations

Unique site of IgG2a and rheumatoid factor production in MRL/lpr mice

1997 • 22 citations

T cells in the pathogenesis of systemic lupus erythematosus

2001 • 16 citations

Treatment of murine lupus with cDNA encoding IFN-?R/Fc

2000 • 11 citations