Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

1991 • 1,783 citations

Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens

1989 • 1,689 citations

New Concepts about the Mast Cell

1993 • 1,009 citations

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Relation between Airway Responsiveness and Serum IgE in Children with Asthma and in Apparently Normal Children

1991 • 806 citations

The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation

1988 • 764 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Cytokine production by mast cells and basophils

1991 • 344 citations

Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells.

1993 • 313 citations

Central role of immunoglobulin (Ig) E in the induction of lung eosinophil infiltration and T helper 2 cell cytokine production: inhibition by a non-anaphylactogenic anti-IgE antibody.

1996 • 304 citations

T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes.

1987 • 286 citations

Successful T cell priming in B cell-deficient mice.

1995 • 284 citations

Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.

1997 • 269 citations

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse

1992 • 262 citations

Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice.

1996 • 251 citations

The B cell is the initiating antigen-presenting cell in peripheral lymph nodes.

1987 • 240 citations

Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing.

1989 • 233 citations

B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes.

1993 • 210 citations

Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.

1995 • 195 citations

Requirement for CD8+ T cells in the development of airway hyperresponsiveness in a marine model of airway sensitization.

1996 • 191 citations

The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice.

1994 • 164 citations

CD8 T cell memory in B cell-deficient mice.

1996 • 158 citations

Inhibition of IgE production and normalization of airways responsiveness by sensitized CD8 T cells in a mouse model of allergen-induced sensitization.

1994 • 156 citations

Nebulized but not parenteral IFN-gamma decreases IgE production and normalizes airways function in a murine model of allergen sensitization.

1994 • 144 citations

Allergen-specific IgG1 and IgG3 through Fc gamma RII induce eosinophil degranulation.

1995 • 120 citations

Inhibition of an in Vivo Antigen-Specific IgE Response by Antibodies to CD23

1993 • 115 citations

Allergen-specific IgE and IL-5 are essential for the development of airway hyperresponsiveness.

1997 • 106 citations

CD4+ T cell activation and tolerance induction in B cell knockout mice.

1996 • 103 citations

Long-lasting CD8 T cell memory in the absence of CD4 T cells or B cells.

1996 • 101 citations

Airway response to electrical field stimulation in sensitized inbred mice. Passive transfer of increased responsiveness with peribronchial lymph nodes.

1992 • 101 citations

IgE‐binding molecules (Mac‐2/ϵBP) expressed by human eosinophils. Implication in IgE‐dependent eosinophil cytotoxicity

1993 • 95 citations

Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen.

1993 • 85 citations

Aerosolized Recombinant Interferon-gamma Prevents Antigen-induced Eosinophil Recruitment in Mouse Trachea

1993 • 84 citations

T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.

1993 • 76 citations

Inhibition of Allergen-Induced IgE and IgG1 Production by Soluble IL-4 Receptor

1995 • 75 citations

B cells are not essential for peripheral T-cell tolerance.

1996 • 65 citations

Strong priming of T cells adoptively transferred into scid mice.

1991 • 42 citations

Apolipoprotein E genotyping in Turkish myocardial infarction survivors and healthy controls

1995 • 14 citations

The IgE receptor of eosinophils

1990 • 6 citations