Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization.

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Mucosal Inflammation in Asthma

1990 • 1,318 citations

Recombinant human interleukin 5 is a selective activator of human eosinophil function.

1988 • 976 citations

Interleukin-5, eosinophils, and disease

1992 • 874 citations

Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity.

1996 • 734 citations

Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor.

1988 • 619 citations

The eosinophil and the pathophysiology of asthma

1986 • 609 citations

T cells and eosinophils in the pathogenesis of asthma

1992 • 585 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Purified interleukin 5 supports the terminal differentiation and proliferation of murine eosinophilic precursors.

1988 • 528 citations

IDENTIFICATION BY IMMUNOFLUORESCENCE OF EOSINOPHIL GRANULE MAJOR BASIC PROTEIN IN LUNG TISSUES OF PATIENTS WITH BRONCHIAL ASTHMA

1982 • 522 citations

Effects of an antibody to interleukin-5 in a monkey model of asthma.

1995 • 335 citations

Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptor.

1993 • 332 citations

Detection of eosinophils using an eosinophil peroxidase assay. Its use as an assay for eosinophil differentiation factors

1985 • 303 citations

Aerosolized antigen exposure without adjuvant causes increased IgE production and increased airway responsiveness in the mouse

1992 • 262 citations

The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human IL-5 enzyme-linked immunosorbent.

1988 • 261 citations

Inhibitory Effect of the TRFK-5 Anti-IL-5 Antibody in a Guinea Pig Model of Asthma

1993 • 226 citations

Eosinophil recruitment into the respiratory epithelium following antigenic challenge in hyper-IgE mice is accompanied by interleukin 5-dependent bronchial hyperresponsiveness.

1995 • 195 citations

The regulation of human eosinophil function by cytokines

1987 • 142 citations

Capsaicin Inhibits Airway Hyperresponsiveness but Not Lipoxygenase Activity or Eosinophilia After Repeated Aerosolized Antigen in Guinea Pigs

1991 • 106 citations

Airway response to electrical field stimulation in sensitized inbred mice. Passive transfer of increased responsiveness with peribronchial lymph nodes.

1992 • 101 citations

Pretreatment with an antibody to interleukin-5 prevents loss of pulmonary M2 muscarinic receptor function in antigen-challenged guinea pigs.

1995 • 98 citations

Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice

1993 • 98 citations

Development and transfer of immediate cutaneous hypersensitivity in mice exposed to aerosolized antigen.

1993 • 85 citations

Isolation and Partial Characterization of Subpopulations of Alveolar Macrophages, Granulocytes, and Highly Enriched Interstitial Macrophages from Rat Lung

1993 • 80 citations

T cells expressing specific V beta elements regulate immunoglobulin E production and airways responsiveness in vivo.

1993 • 76 citations

Mechanisms of allergic pulmonary eosinophilia in the mouse

1994 • 70 citations

Increased acetylcholine release in tracheas from allergen-exposed IgE-immune mice

1994 • 63 citations

Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse.

1994 • 55 citations

Inhibition of antigen-induced airway hyperresponsiveness, but not acute hypoxia nor airway eosinophilia, by an antagonist of platelet-activating factor.

1990 • 52 citations

Antigen-mediated pulmonary eosinophilia in immunoglobulin G1-sensitized guinea pigs: eosinophil peroxidase as a simple specific marker for detecting eosinophils in bronchoalveolar lavage fluid.

1993 • 22 citations