IL-12-Dependent Vascular Cell Adhesion Molecule-1 Expression Contributes to Airway Eosinophilic Inflammation in a Mouse Model of Asthma-Like Reaction

Immunobiology of Dendritic Cells

2000 • 6,653 citations

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Eosinophilic Inflammation in Asthma

1990 • 2,535 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

The Th1/Th2 paradigm

1997 • 1,102 citations

IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

1996 • 991 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Identification of Activated T Lymphocytes and Eosinophils in Bronchial Biopsies in Stable Atopic Asthma

1990 • 890 citations

The Eosinophilic Leukocyte: Structure and Function

1986 • 828 citations

Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation.

1994 • 822 citations

The α(1,3)Fucosyltransferase Fuc-TVII Controls Leukocyte Trafficking through an Essential Role in L-, E-, and P-selectin Ligand Biosynthesis

1996 • 723 citations

Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.

1996 • 719 citations

Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules.

1991 • 675 citations

CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

1998 • 667 citations

CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells

1999 • 638 citations

Antibody to Interleukin-5 Inhibits Helminth-Induced Eosinophilia in Mice

1989 • 635 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia

1997 • 537 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

Induction of Airway Mucus Production By T Helper 2 (Th2) Cells: A Critical Role For Interleukin 4 In Cell Recruitment But Not Mucus Production

1997 • 464 citations

Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation.

1997 • 419 citations

DNA Vaccination: Transfection and Activation of Dendritic Cells as Key Events for Immunity

1999 • 367 citations

Differential Regulation of Murine T Lymphocyte Subsets

1993 • 343 citations

A monoclonal antibody that detects a novel antigen on endothelial cells that is induced by tumor necrosis factor, IL-1, or lipopolysaccharide.

1990 • 339 citations

Increases in Activated T Lymphocytes, Eosinophils, and Cytokine mRNA Expression for Interleukin-5 and Granulocyte/Macrophage Colony-stimulating Factor in Bronchial Biopsies after Allergen Inhalation Challenge in Atopic Asthmatics

1993 • 336 citations

Role of vascular cell adhesion molecule 1/very late activation antigen 4 and intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 interactions in antigen-induced eosinophil and T cell recruitment into the tissue.

1994 • 312 citations

IL-4 regulates endothelial cell activation by IL-1, tumor necrosis factor, or IFN-gamma.

1990 • 311 citations

Human eosinophil, but not neutrophil, adherence to IL-1-stimulated human umbilical vascular endothelial cells is alpha 4 beta 1 (very late antigen-4) dependent.

1991 • 295 citations

Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway

1991 • 279 citations

Mechanisms of eosinophil adherence to cultured vascular endothelial cells. Eosinophils bind to the cytokine-induced ligand vascular cell adhesion molecule-1 via the very late activation antigen-4 integrin receptor.

1991 • 268 citations

Mouse Eotaxin Expression Parallels Eosinophil Accumulation during Lung Allergic Inflammation but It Is Not Restricted to a Th2-Type Response

1996 • 260 citations

Kinetics of Eotaxin Generation and Its Relationship to Eosinophil Accumulation in Allergic Airways Disease: Analysis in a Guinea Pig Model In Vivo

1997 • 255 citations

Regulation of vascular cell adhesion molecule-1 expression by IL-4 and TNF-alpha in cultured endothelial cells.

1995 • 235 citations

Human eosinophil adherence to vascular endothelium mediated by binding to vascular cell adhesion molecule 1 and endothelial leukocyte adhesion molecule 1.

1991 • 233 citations

Effects of tumor necrosis factor, lipopolysaccharide, and IL-4 on the expression of vascular cell adhesion molecule-1 in vivo. Correlation with CD3+ T cell infiltration.

1992 • 227 citations

Coordinated events during bacteria-induced DC maturation

1999 • 219 citations

Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels.

1998 • 191 citations

Chemokine-induced eosinophil recruitment. Evidence of a role for endogenous eotaxin in an in vivo allergy model in mouse skin.

1997 • 173 citations

Prevention of Th2-Like Cell Responses by Coadministration of IL-12 and IL-18 Is Associated with Inhibition of Antigen-Induced Airway Hyperresponsiveness, Eosinophilia, and Serum IgE Levels

1998 • 170 citations

Endogenous IL-12 is required for control of Th2 cytokine responses capable of exacerbating leishmaniasis in normally resistant mice.

1995 • 162 citations

Immunomodulatory effects of IL-12 on allergic lung inflammation depend on timing of doses.

1996 • 143 citations

Variations of Blood Eosinophils and Eosinophil Cationic Protein in Serum in Patients with Bronchial Asthma

1978 • 133 citations

Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity

1998 • 117 citations

Alloantigen-Reactive Th1 Development in IL-12-Deficient Mice

1998 • 110 citations

Interleukin-5 is a human basophilopoietin: induction of histamine content and basophilic differentiation of HL-60 cells and of peripheral blood basophil-eosinophil progenitors

1991 • 108 citations

Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1

1997 • 99 citations

Chemically modified antigen preferentially elicits induction of Th1-like cytokine synthesis patterns in vivo.

1993 • 98 citations

Astrocyte-Targeted Expression of IL-12 Induces Active Cellular Immune Responses in the Central Nervous System and Modulates Experimental Allergic Encephalomyelitis

2000 • 96 citations

In vivo neutralization of eosinophil-derived major basic protein inhibits antigen-induced bronchial hyperreactivity in sensitized guinea pigs.

1996 • 85 citations

IL-10 deficiency prevents IL-5 overproduction and eosinophilic inflammation in a murine model of asthma-like reaction

2000 • 84 citations

Gene expression and secretion of cytokines and cytokine receptors from highly purified CD56⁺ natural killer cells stimulated with interleukin‐2, interleukin‐7 and interleukin‐12

1993 • 77 citations

IL-12 exacerbates helminth-mediated corneal pathology by augmenting inflammatory cell recruitment and chemokine expression.

1997 • 62 citations

A critical role for a peritumoral stromal reaction in the induction of T-cell migration responsible for interleukin-12-induced tumor regression.

1999 • 51 citations

Regulation of Allergic Mucosal Sensitization by Interleukin-12 Gene Transfer to the Airway

1999 • 50 citations

Vascular Cell Adhesion Molecule-1 and Eosinophil Adhesion to Cultured Human Umbilical Vein Endothelial Cells In Vitro

1991 • 44 citations

Interleukin-12-induced adhesion molecule expression in murine liver.

1998 • 43 citations

Systemic mycobacterial infection inhibits antigen‐specific immunoglobulin E production, bronchial mucus production and eosinophilic inflammation induced by allergen

1999 • 39 citations

Allergen-dependent induction of interleukin-4 synthesis in vivo.

1993 • 32 citations

Degranulation of eosinophils mediated by intercellular adhesion molecule-1 and its ligands is involved in adhesion molecule expression on endothelial cells–selective induction of VCAM-1

1999 • 21 citations

Regulation of human eosinophil production and function by interleukin-5.

1992 • 18 citations

Endogenous IL-12 synthesis is not required to prevent hyperexpression of type 2 cytokine and antibody responses

2000 • 16 citations