Reaction of hematin with allylic fatty acid hydroperoxides: identification of products and implications for pathways of hydroperoxide-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1983 • 2,839 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1974 • 1,144 citations

Deuterium-isotope Effects in the Autoxidation of Aralkyl Hydrocarbons. Mechanism of the Interaction of PEroxy Radicals¹

1957 • 1,082 citations

On the function and mechanism of action of peroxidases

1976 • 1,017 citations

Oxygen Activation by Cytochrome P-4501

1980 • 1,013 citations

Oxy-Radicals and Related Species: Their Formation, Lifetimes, and Reactions

1986 • 958 citations

Mechanisms and Consequences of Lipid Peroxidation in Biological Systems

1985 • 520 citations

The reaction of singlet oxygen with olefins: the question of mechanism

1979 • 485 citations

Chemical mechanisms of catalysis by cytochromes P-450: a unified view

1984 • 481 citations

The mechanism of NADPH-dependent lipid peroxidation. The propagation of lipid peroxidation.

1979 • 390 citations

Metabolic conversion of benzo[a]pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid

1973 • 315 citations

Enzymatic conversion of benzo(a)pyrene leading predominantly to the diol-epoxide r-7,t-8-dihydroxy-t-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene through a single enantiomer of r-7, t-8-dihydroxy-7,8-dihydrobenzo(a)pyrene.

1976 • 270 citations

Peroxyl free radicals: potential mediators of tumor initiation and promotion

1987 • 269 citations

Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides.

1976 • 206 citations

Organotin hydrides and organic free radicals

1968 • 199 citations

Free radicals in tumor promotion

1986 • 198 citations

Conversion of linoleic acid hydroperoxide to hydroxy, keto, epoxyhydroxy, and trihydroxy fatty acids by hematin.

1985 • 197 citations

Peresters. V.¹ Di-t-butylperoxyoxalate

1960 • 189 citations

Epoxidation of styrene by hemoglobin and myoglobin. Transfer of oxidizing equivalents to the protein surface.

1985 • 175 citations

Metabolism of Polycyclic Aromatic Hydrocarbon Derivatives to Ultimate Carcinogens During Lipid Peroxidation

1983 • 162 citations

Homolytic decomposition of linoleic acid hydroperoxide: Identification of fatty acid products

1974 • 156 citations

Decomposition of unsaturated fatty acid hydroperoxides by hemoglobin: Structures of major products of 13L‐hydroperoxy‐9,11‐octadecadienoic acid

1975 • 154 citations

Simple synthesis of a 4a-hydroperoxy adduct of a 1,5-dihydroflavine: preliminary studies of a model for bacterial luciferase.

1976 • 143 citations

Alkane hydroxylation catalyzed by metalloporhyrins : evidence for different active oxygen species with alkylhydroperoxides and iodosobenzene as oxidants.

1982 • 130 citations

Evidence for a homolytic mechanism of peroxide oxygen–oxygen bond cleavage during substrate hydroxylation by cytochrome P-450.

1980 • 124 citations

The mechanism of the rearrangement of linoleate hydroperoxides

1979 • 116 citations

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

1974 • 113 citations

Some aspects of the chemistry of alkoxy radicals

1967 • 107 citations

Polycyclic aromatic hydrocarbon oxidation during prostaglandin biosynthesis

1981 • 104 citations

Radical-induced ring opening of epoxides. A convenient alternative to the wharton rearrangement

1981 • 99 citations

The hepatic microsomal biotransformation of delta 5-steroids to 5 alpha, 6 beta-glycols via alpha- and beta-epoxides.

1981 • 98 citations

The enzymic oxidative breakdown of linoleic acid in mushrooms (Psalliota bispora)

1982 • 96 citations

The formation of cyclic peroxides from unsaturated hydroperoxides: models for prostaglandin biosynthesis

1976 • 96 citations

Degradation of linoleic acid hydroperoxides by a cysteine FeCl3 catalyst as a model for similar biochemical reactions

1981 • 93 citations

Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides.

1985 • 90 citations

Origin of the oxygen in the products of the enzymatic cleavage reaction of linoleic acid to 1-octen-3-ol and 10-oxo-trans-8-decenoic acid in mushrooms (Psalliota bispora)

1984 • 85 citations

Homolytic and heterolytic oxygen-oxygen bond scissions accompanying oxygen transfer to iron(III) porphyrins by percarboxylic acids and hydroperoxides. A mechanistic criterion for peroxidase and cytochrome P-450

1985 • 81 citations

Free radical epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by hematin and polyunsaturated fatty acid hydroperoxides

1981 • 80 citations

Allylic hydroperoxide rearrangement. .beta.-Scission or concerted pathway?

1987 • 76 citations

In the presence of imidazole, iron-and manganese-porphyrins catalyse the epoxidation of alkenes by alkyl hydroperoxides

1984 • 74 citations

Arachidonic acid‐dependent metabolism of 7,8‐dihydroxy‐7,8‐dihydrobenzo[a]pyrene by ram seminal vesicles

1979 • 69 citations

A biomimetic model for catalase: the mechanisms of reaction of hydrogen peroxide and hydroperoxides with iron(III) porphyrins

1987 • 64 citations

Enzymic oxidation of linolenic acid to 1,Z‐5‐octadien‐3‐ol, Z‐2,Z‐5‐octadien‐1‐ol and 10‐oxo‐E‐8‐decenoic acid by a protein fraction from mushrooms (Psalliota bispora)

1986 • 58 citations

Phenylbutazone-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene. A new mechanism for prostaglandin H synthase-catalyzed oxidations.

1984 • 56 citations

A short-chain aldehyde is a major lipoxygenase product in arachidonic acid-stimulated porcine leukocytes.

1986 • 55 citations

Arachidonic acid‐dependent metabolism of (±) trans‐7,8‐dihydroxy‐7,8‐ dihydro‐benzo[a]pyrene (BP‐7,8 diol) to 7,10/8,9 tetrols

1979 • 55 citations

Hematin-catalyzed rearrangement of hydroperoxylinoleic acid to epoxy alcohols via an oxygen rebound

1983 • 54 citations

Cooxidation of styrene by horseradish peroxidase and phenols: a biochemical model for protein-mediated cooxidation

1987 • 53 citations

10-Hydroperoxy-8,12-octadecadienoic acid. A diagnostic probe of alkoxyl radical generation in metal-hydroperoxide reactions

1987 • 53 citations

The chromatographic analysis of organic peroxides

1957 • 53 citations

Hydroperoxide-dependent oxygenation of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by ram seminal vesicle microsomes. Source of the oxygen

1980 • 45 citations

Hydrocarbon formation in the reductive cleavage of hydroperoxides by cytochrome P-450.

1987 • 44 citations

Model compound studies related to peroxidases-II

1984 • 43 citations

Isolation and characterization of peroxy-Y base from phenylalanine transfer ribonucleic acid of the plant, Lupinus luteus

1974 • 43 citations

Oxene transfer, electron abstraction, and cooxidation in the epoxidation of stilbene and 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by hemoglobin

1987 • 38 citations

Conversion of arachidonic acid into 12-oxo derivatives in human platelets. A pathway possibly involving the heme-catalysed transformation of 12-hydroperoxy-eicosatetraenoic acid

1987 • 36 citations

Stereoselectivity of the epoxidation of 7,8-dihydrobenzo[a]pyrene by prostaglandin H synthase and cytochrome P-450 determined by the identification of polyguanylic acid adducts.

1983 • 31 citations

Epoxidation of cholesterol by hepatic microsomal lipid hydroperoxides

1982 • 26 citations

Über En‐synthesen mit Singulett‐Sauerstoff [1] II. Die Farbstoff‐sensibilisierte Photooxygenierung von (—)‐Thujopsen und die Stereochemie der dargestellten Thujopsanole

1970 • 26 citations

Effect of strain on singlet oxygen (1O2) reactions. 2. Photooxidation of methylenecyclopropanes

1979 • 24 citations

The reaction of Singlet Oxygen with 1-Methoxycyclohexene

1978 • 21 citations

[43] Detection of the metabolism of polycyclic aromatic hydrocarbon derivatives to ultimate carcinogens during lipid peroxidation

1984 • 17 citations

Reaction of dihydrohexamethyl(Dewar benzene) with singlet oxygen

1977 • 15 citations

Further studies on the oxy-functionalization of cholesteryl acetate with tert-butyl hydroperoxide and tris(acetylacetonato)iron(III).

1981 • 4 citations