Platelet activation by oxidatively modified low density lipoproteins

Practical Methods for Plasma Lipoprotein Analysis1 1Work supported in part by the U.S. Atomic Energy Commission and by grants (HE06222 and FR00102) from the U.S. Public Health Service.

1968 • 1,255 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit.

1987 • 1,051 citations

Platelet Function in Hyperlipoproteinemia

1974 • 682 citations

Lipid Peroxides in Biology and Medicine

1982 • 640 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Lipoprotein oxidation and lipoprotein-induced cytotoxicity.

1983 • 545 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

ASSAY FOR SERUM LIPID PEROXIDE LEVEL AND ITS CLINICAL SIGNIFICANCE

1982 • 302 citations

Platelet activation.

1985 • 172 citations

Platelet interaction with high and low density lipoproteins

1983 • 145 citations

Abnormalities of cholesterol-phospholipid composition in platelets and low-density lipoproteins of human hyperbetalipoproteinemia.

1977 • 138 citations

Platelet protein phosphorylation, elevation of cytosolic calcium, and inositol phospholipid breakdown in platelet activation induced by plasmin.

1986 • 124 citations

The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin

1983 • 118 citations

Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism.

1988 • 116 citations

Increased platelet sensitivity and thromboxane B₂ formation in type‐II hyperlipoproteinaemic patients

1984 • 106 citations

Platelet function and platelet lipid composition in the dyslipoproteinemias

1980 • 103 citations

Intracellular mechanisms in the activation of human platelets by low-density lipoproteins

1987 • 101 citations

The role of altered lipoproteins in the pathogenesis of atherosclerosis

1987 • 94 citations

PLATELET FUNCTION AND PLATELET PHOSPHOLIPIDS IN PATIENTS WITH HYPERBETALIPOPROTEINEMIA

1971 • 88 citations

Increased in vivo and in vitro platelet function in type II- and type IV-hyperlipoproteinemia

1979 • 82 citations

Influence of plasma lipoproteins on platelet aggregation in a normal male population.

1983 • 74 citations

Platelet Sensitivity to Prostacyclin and Thromboxane Production in Hyperlipidemic Patients

1982 • 67 citations

Characterization of the Effect of Plasma Lipoproteins on Platelet Function in vitro

1983 • 66 citations

Membrane microenvironmental changes during activation of human blood platelets by thrombin. A study with a fluorescent probe.

1979 • 63 citations

Platelet formation of 12-hydroxyeicosatetraenoic acid and thromboxane B2 is increased in type IIA hypercholesterolemic subjects

1986 • 46 citations

Platelet Function and Lipoprotein Levels after Plasma-Exchange in Patients with Familial Hypercholesterolaemia

1983 • 44 citations

Thrombin binding and response in platelets from patients with dyslipoproteinemias: increased stimulus-response coupling in type II hyperlipoproteinemia

1986 • 37 citations

The facilitating effects of adrenaline on platelet aggregation

1982 • 37 citations

Plasma lipoproteins affect platelet malondialdehyde and thromboxane B2 production

1985 • 37 citations

Abnormal plasma lipoprotein composition in hypercholesterolaemic patients induces platelet activation

1984 • 37 citations

The effect of blood constituents on platelet function: role of blood cells and plasma lipoproteins.

1983 • 36 citations

Prostacyclin-lipoprotein interactions

1985 • 29 citations

Endogenous lipoproteins modify the thromboxane formation capacity of platelets

1986 • 23 citations

Thromboxane A2 (TXA2) formation by washed human platelets under the influence of low and high density lipoproteins from healthy donors

1986 • 22 citations

Platelet function in familial hypercholesterolaemia in south africa and the effects of probucol

1982 • 17 citations

Platelet function in hyperlipoproteinaemia.

1985 • 15 citations

Platelets and Coagulation in Patients with Familial Hypercholesterolemia (Type Ha)

1983 • 14 citations

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