The anatomical basis of intestinal immunity

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Interleukin-10-deficient mice develop chronic enterocolitis

1993 • 4,225 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1993 • 1,762 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

1995 • 1,338 citations

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

Experimental models of inflammatory bowel disease

1995 • 1,215 citations

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the αEβ7 integrin

1994 • 1,131 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses.

1996 • 1,128 citations

The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats.

1994 • 1,128 citations

Phenotypically distinct subsets of CD4⁺ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice

1993 • 1,064 citations

Tolerance exists towards resident intestinal flora but is broken in active inflammatory bowel disease (IBD)

1995 • 965 citations

The mucosal immune system: from fundamental concepts to vaccine development

1992 • 912 citations

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells.

1996 • 909 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches.

1994 • 859 citations

Peripheral deletion of antigen-reactive T cells in oral tolerance

1995 • 775 citations

Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers.

1989 • 761 citations

Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering.

1992 • 734 citations

Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues.

1979 • 732 citations

Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice

1993 • 732 citations

Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain.

1992 • 726 citations

Altered Peptide Ligand–Induced Partial T Cell Activation: Molecular Mechanisms and Role in T Cell Biology

1996 • 698 citations

Inflammatory Bowel Disease and Adenomas in Mice Expressing a Dominant Negative N-Cadherin

1995 • 672 citations

Modulation of Epithelial Cell Growth by Intraepithelial γδ T Cells

1994 • 644 citations

Induction of anergy or active suppression following oral tolerance is determined by antigen dosage.

1994 • 643 citations

Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis

1993 • 634 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo.

1994 • 625 citations

Cytokines in intestinal inflammation: Pathophysiological and clinical considerations

1994 • 607 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis

1993 • 592 citations

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

1994 • 578 citations

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

1996 • 558 citations

Evidence for function of Ia molecules on gut epithelial cells in man.

1987 • 521 citations

Distinct roles of L-selectin and integrins α4β7 and LFA-1 in lymphocyte homing to Peyer's patch-HEV in situ: The multistep model confirmed and refined

1995 • 520 citations

The regulation of immune responses to dietary protein antigens

1987 • 489 citations

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.

1993 • 471 citations

Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.

1993 • 457 citations

Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.

1996 • 444 citations

Antigen-driven bystander suppression after oral administration of antigens.

1991 • 438 citations

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness.

1995 • 436 citations

Evidence that activated mucosal T cells play a role in the pathogenesis of enteropathy in human small intestine.

1988 • 404 citations

Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments.

1988 • 404 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR)

1995 • 400 citations

T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.

1996 • 399 citations

Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs.

1996 • 392 citations

Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4.

1995 • 392 citations

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

1995 • 376 citations

Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch.

1996 • 360 citations

T cells in inflammatory bowel disease: protective and pathogenic roles

1995 • 359 citations

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin‐10 or antibodies to interleukin‐12

1996 • 358 citations

Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen.

1986 • 357 citations

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells.

1995 • 357 citations

Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma.

1995 • 346 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa.

1993 • 324 citations

Intraepithelial T Cells of the TcRγ/δ⁺CD8⁻ and Vδ1/Jδ1⁺ Phenotypes are Increased in Coeliac Disease

1989 • 311 citations

M Cells in Peyer's Patches of the Intestine

1996 • 310 citations

Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen.

1990 • 288 citations

Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo.

1993 • 284 citations

Localization of gamma/delta T cells to the intestinal epithelium is independent of normal microbial colonization.

1990 • 281 citations

Involvement of M cells in the bacterial invasion of Peyer's patches: a common mechanism shared by Yersinia enterocolitica and other enteroinvasive bacteria.

1990 • 276 citations

Cellular Aspects of Immunoglobulin A

1976 • 275 citations

The distribution, ontogeny and origin in the rat of Ia‐positive cells with dendritic morphology and of Ia antigen in epithelia, with special reference to the intestine

1983 • 274 citations

Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells.

1991 • 268 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Expansion of alpha beta T-cell receptor-bearing intestinal intraepithelial lymphocytes after microbial colonization in germ-free mice and its independence from thymus.

1993 • 266 citations

Immunologic suppression after oral administration of antigen. I. Specific suppressor cells formed in rat Peyer's patches after oral administration of sheep erythrocytes and their systemic migration.

1978 • 263 citations

Extrathymic origin of intestinal intraepithelial lymphocytes bearing T-cell antigen receptor gamma delta.

1991 • 262 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella.

1996 • 256 citations

Antigen presentation by epithelial cells of the rat small intestine. II. Selective induction of suppressor T cells.

1986 • 252 citations

Expression of disulfide‐linked and non‐disulfide‐linked forms of the T cell receptor γ/δ heterodimer in human intestinal intraepithelial lymphocytes

1989 • 248 citations

Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.

1996 • 243 citations

Oligoclonal Expansion and CD1 Recognition by Human Intestinal Intraepithelial Lymphocytes

1991 • 243 citations

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium.

1996 • 242 citations

Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide.

1994 • 236 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

Avian T cells expressing gamma delta receptors localize in the splenic sinusoids and the intestinal epithelium.

1988 • 234 citations

Direct evidence for anergy in T lymphocytes tolerized by oral administration of ovalbumin

1993 • 233 citations

Gamma delta T lymphocytes regulate the induction and maintenance of oral tolerance.

1997 • 227 citations

A family of beta 7 integrins on human mucosal lymphocytes.

1992 • 227 citations

Impaired mucosal immune responses in interleukin 4-targeted mice.

1995 • 227 citations

Endotoxin-mediated dendritic cell release from the intestine. Characterization of released dendritic cells and TNF dependence.

1995 • 226 citations

Analysis of Th1 and Th2 cells in murine gut-associated tissues. Frequencies of CD4+ and CD8+ T cells that secrete IFN-gamma and IL-5.

1990 • 226 citations

Cytokine imbalance and autoantibody production in T cell receptor-alpha mutant mice with inflammatory bowel disease.

1996 • 224 citations

Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression.

1995 • 222 citations

Expression and regulation of β₇(βp) integrins on mouse lymphocytes: Relevance to the mucosal immune system

1991 • 222 citations

Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells.

1989 • 219 citations

Vascular addressins are induced on islet vessels during insulitis in nonobese diabetic mice and are involved in lymphoid cell binding to islet endothelium.

1993 • 218 citations

Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice.

1994 • 208 citations

Murine enterocytes can present soluble antigen to specific class II‐restricted CD4⁺ T cells

1989 • 203 citations

Multiple immune abnormalities in tumor necrosis factor and lymphotoxin-α double-deficient mice

1996 • 201 citations

Expanding the role of Peyer's patches in B-cell ontogeny

1996 • 197 citations

A large proportion of bovine T cells express the γδ T cell receptor and show a distinct tissue distribution and surface phenotype

1989 • 195 citations

Chronic intestinal inflammation: An unexpected outcome in cytokine or T cell receptor mutant mice

1993 • 193 citations

Expression of the mucosal vascular addressin, MAdCAM-1, on sinus-lining cells in the spleen.

1995 • 188 citations

Severe colitis in mice with aberrant thymic selection

1995 • 186 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Cytotoxic differentiation of mouse gut thymodependent and independent intraepithelial T lymphocytes is induced locally. Correlation between functional assays, presence of perforin and granzyme transcripts, and cytoplasmic granules.

1991 • 183 citations

Definition of a lamina propria T cell responsive state. Enhanced cytokine responsiveness of T cells stimulated through the CD2 pathway.

1995 • 182 citations

Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor.

1996 • 181 citations

Gut intraepithelial T lymphocytes

1993 • 181 citations

IL-4 directly modulates function of a model human intestinal epithelium.

1994 • 181 citations

gamma/delta T cell-deficient mice have impaired mucosal immunoglobulin A responses.

1996 • 181 citations

Antibodies to IFN-gamma prevent immunologically mediated intestinal damage in murine graft-versus-host reaction.

1989 • 178 citations

Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats.

1986 • 176 citations

Frontiers of the immune system

1988 • 174 citations

Human intestinal intraepithelial lymphocytes are derived from a limited number of T cell clones that utilize multiple V beta T cell receptor genes.

1993 • 174 citations

Regulation of intestinal epithelial barrier function by TGF-beta 1. Evidence for its role in abrogating the effect of a T cell cytokine.

1994 • 172 citations

Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

1994 • 167 citations

Gamma delta T cells down-regulate primary IgE responses in rats to inhaled soluble protein antigens.

1995 • 167 citations

T cell differentiation antigens on lymphocytes in the human intestinal lamina propria.

1992 • 165 citations

Expression of the thymus leukemia antigen in mouse intestinal epithelium.

1990 • 161 citations

Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

1995 • 160 citations

Localization of transforming growth factor β isoforms in the normal murine small intestine and colon

1993 • 157 citations

Novel Delivery Systems for Oral Vaccines

1994 • 155 citations

β ₂ -Microglobulin-Independent MHC Class Ib Molecule Expressed by Human Intestinal Epithelium

1994 • 154 citations

CD4⁺ but not CD8⁺T cells are required for the induction of oral tolerance

1995 • 153 citations

Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine.

1996 • 151 citations

Extrathymic intestinal T-cell development: virtual reality?

1995 • 149 citations

Oral type II collagen treatment in early rheumatoid arthritis. A double‐blind, placebo‐controlled, randomized trial

1996 • 147 citations

Isolation and characterization of antigen-presenting dendritic cells from the mouse intestinal lamina propria.

1990 • 145 citations

Grains of truth: evolutionary changes in small intestinal mucosa in response to environmental antigen challenge.

1990 • 144 citations

Evidence that CD4⁺, but not CD8⁺ T cells are responsible for murine interleukin‐2‐deficient colitis

1995 • 144 citations

Differentiation and functional maturation of bone marrow-derived intestinal epithelial T cells expressing membrane T cell receptor in athymic radiation chimeras.

1990 • 144 citations

CD1d is involved in T cell-intestinal epithelial cell interactions.

1993 • 143 citations

Intraepithelial lymphocytes in human gut have lytic potential and a cytokine profile that suggest T helper 1 and cytotoxic functions.

1996 • 143 citations

Proliferative responses of human intraepithelial lymphocytes to various T-cell stimuli

1989 • 138 citations

Oral Tolerance in Experimental Autoimmune Encephalomyelitis

1996 • 136 citations

Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats

1996 • 136 citations

Migration and homing of lymphoid cells

1988 • 136 citations

Phenotypic analysis of lamina propria lymphocytes. Predominance of helper-inducer and cytolytic T-cell phenotypes and deficiency of suppressor-inducer phenotypes in Crohn's disease and control patients.

1986 • 135 citations

Interleukin-4 and Interleukin-13 Differentially Regulate Epithelial Chloride Secretion

1996 • 133 citations

Inhibition of specific immune responses by feeding protein antigens. IV. Evidence for tolerance and specific active suppression of cell-mediated immune responses to ovalbumin.

1979 • 131 citations

Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells.

1994 • 130 citations

Intestinal γ/δ Receptor-Bearing T Lymphocytes in Celiac Disease and Inflammatory Bowel Diseases in Children. Constant Increase in Celiac Disease

1990 • 130 citations

Regulation of Immune Responses of the Intestinal Mucosa

1996 • 130 citations

Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.

1994 • 123 citations

Cholera toxin adjuvant greatly promotes antigen priming of T cells

1993 • 121 citations

Expression of homing and adhesion molecules in infiltrated islets of Langerhans and salivary glands of nonobese diabetic mice.

1994 • 121 citations

Complexity of the mouse gut T cell immune system: Identification of two distinct natural killer T cell intraepithelial lineages

1996 • 120 citations

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.

1994 • 120 citations

Structure and Function of the CD1 Family of MHC‐like Cell Surface Proteins

1995 • 119 citations

Anti-γδ T cell antibody blocks the induction and maintenance of oral tolerance to ovalbumin in mice

1995 • 118 citations

Direct measurement of anergy of antigen-specific T cells following oral tolerance induction.

1996 • 118 citations

Phenotypic analysis of lamina propria lymphocytes

1986 • 117 citations

Intestinal intraepithelial lymphocytes are activated and cytolytic but do not proliferate as well as other T cells in response to mitogenic signals.

1993 • 117 citations

Phenotype of intraepithelial lymphocytes in euthymic and athymic mice: Implications for differentiation of cells bearing a CD3‐associated γδ T cell receptor

1990 • 116 citations

Phenotypic and functional characterization of CD11c⁺ dendritic cell population in mouse Peyer's patches

1996 • 110 citations

Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells

1995 • 110 citations

Expression of intercellular adhesion molecule 1 (ICAM-1, CD54) in colonic epithelial cells.

1993 • 108 citations

Different expression of the recombination activity gene RAG‐1 in various populations of thymocytes, peripheral T cells and gut thymus‐independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement

1992 • 107 citations

Structure and Function of Intestinal Mucosal Epithelium

1994 • 105 citations

Tumour Necrosis factor-α induces morphological and functional alterations of intestinal HT29 cl.19A cell monolayers

1995 • 104 citations

Proliferative recruitment of intestinal intraepithelial lymphocytes after microbial colonization of germ‐free mice

1996 • 103 citations

Nitric oxide mediates intestinal pathology in graft-vs.-host disease

1992 • 103 citations

Molecular cloning of the human mucosal lymphocyte integrin alpha E subunit. Unusual structure and restricted RNA distribution.

1994 • 101 citations

Oral antigen inhibits priming of CD8+ CTL, CD4+ T cells, and antibody responses while activating CD8+ suppressor T cells.

1996 • 101 citations

The human intraepithelial lymphocyte marker HML‐1 is an integrin consisting of a β7 subunit associated with a distinctive α chain

1992 • 101 citations

Human Intestinal B‐Cell Blasts and Plasma Cells Express the Mucosal Homing Receptor Integrin α4β7

1995 • 99 citations

Differential responsiveness to CD3‐Ti vs. CD2‐dependent activation of human intestinal T lymphocytes

1990 • 97 citations

Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine.

1992 • 97 citations

Mechanisms of Oral Tolerance

1997 • 96 citations

Developmental expression of the α_IELβ₇ integrin on T cell receptor γδ and T cell receptor αβ T cells

1994 • 94 citations

Inhibition of Specific Immune Responses by Feeding Protein Antigens

1979 • 93 citations

Distribution of β₇ integrins in human intestinal mucosa and organized gut‐associated lymphoid tissue

1996 • 93 citations

Listeria monocytogenes-induced gamma interferon secretion by intestinal intraepithelial gamma/delta T lymphocytes

1993 • 91 citations

The ?7 integrins in mucosal homing and retention

1995 • 87 citations

Oral Tolerance and Regulation of Immunity to Dietary Antigens

1994 • 86 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

Gamma/delta T cells in the gut epithelium.

1990 • 84 citations

Differential regulation of B7 mRNA in enterocytes and lymphoid cells.

1993 • 84 citations

Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.

1993 • 80 citations

Peripheral tolerance of T_h2 lymphocytes induced by continuous feeding of ovalbumin

1996 • 80 citations

Structure and Function of Intestinal M Cells

1991 • 80 citations

Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness

1993 • 80 citations

Cytotoxic α/β⁺ and γ/δ⁺ T cells in murine intestinal epithelium

1990 • 79 citations

Gi2? protein deficiency: A model for inflammatory bowel disease

1995 • 78 citations

CD3⁻CD8⁺ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL

1994 • 78 citations

Effect of in Vivo Depletion of CD4+ and CD8+ Cells on the Induction and Maintenance of Oral Tolerance

1995 • 74 citations

Human intestinal epithelial cell-induced CD8+ T cell activation is mediated through CD8 and the activation of CD8-associated p56lck.

1995 • 73 citations

T-cell receptor expression in intestinal intra-epithelial lymphocyte subpopulations of normal and athymic mice.

1989 • 73 citations

Common Mucosal Immune System and Strategies for the Development of Vaccines Effective at the Mucosal Surfaces

1994 • 73 citations

Orally induced, peptide‐specific γ/δ TCR⁺ cells suppress experimental autoimmune uveitis

1996 • 72 citations

Developmental relationship between cytotoxic α/β T cell receptor‐positive intraepithelial lymphocytes and Peyer's patch lymphocytes

1993 • 72 citations

Synthesis and regulation of accessory/proinflammatory cytokines by intestinal epithelial cells

1995 • 72 citations

Entry of microbes into the host: using M cells to break the mucosal barrier

1995 • 71 citations

Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation.

1994 • 71 citations

The expansion and selection of T cell receptor αβ intestinal intraepithelial T cell clones

1996 • 67 citations

Phenotypic heterogeneity of intraepithelial T lymphocytes from mouse small intestine.

1991 • 67 citations

Rat intestinal dendritic cells: immunostimulatory potency and phenotypic characterization.

1995 • 67 citations

Graft-versus-host disease

1997 • 66 citations

Expression of T cell receptors TcR1 (gamma/delta) and TcR2 (alpha/beta) in the human intestinal mucosa

1990 • 64 citations

The role of small intestinal antigen‐presenting cells in the induction of T‐cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance

1996 • 64 citations

Expression of the mucosal T cell integrin αM290β7 by a major subpopulation of dendritic cells in mice

1993 • 63 citations

Ontogeny of non-lymphoid and lymphoid cells in the rat gut with special reference to large mononuclear Ia-positive dendritic cells.

1983 • 63 citations

High frequency of CD8αα homodimer‐bearing T cells in human fetal intestine

1994 • 63 citations

Antigen presentation by macrophage-enriched cells from the mouse Peyer's patch

1981 • 63 citations

A synergistic relationship between TNF-alpha, IL-1 beta, and TGF-beta 1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line.

1995 • 63 citations

Distinct structural and functional epitopes of the α^Eβ₇ integrin

1994 • 62 citations

Regulation of Sucrase-Isomaltase Gene Expression in Human Intestinal Epithelial Cells by Inflammatory Cytokines

1996 • 62 citations

Adhesion molecules intercellular adhesion molecule-1 (ICAM-1), ICAM-3 and B7 are not expressed by epithelium in normal or inflamed colon

1995 • 62 citations

Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

1996 • 62 citations

Intestinal intraepithelial lymphocytes: the plot thickens.

1994 • 62 citations

Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCRαβ or TCRτδ are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex

1991 • 61 citations

Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: predominance of T cell receptor α/β⁺/CD2⁻ cells and high expression of the RT6 alloantigen

1991 • 58 citations

Epithelial and Hepatobiliary Transport of Polymeric Immunoglobulins

1994 • 58 citations

Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation.

1996 • 57 citations

Oral tolerance to haptens: intestinal epithelial cells from 2,4-dinitrochlorobenzene-fed mice inhibit hapten-specific T cell activationin vitro

1995 • 55 citations

Intraepithelial lymphocytes of the intestinal mucosa: curiouser and curiouser.

1991 • 54 citations

Intraocular Inflammatory Disease (Uveitis) and the Use of Oral Tolerance.

1996 • 54 citations

Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice

1994 • 53 citations

Progenies of fetal thymocytes are the major source of CD4⁻CD8⁺ αα intestinal intraepithelial lymphocytes early in ontogeny

1994 • 52 citations

Development and cytolytic function of intestinal intraepithelial T lymphocytes in antigen‐minimized mice

1996 • 51 citations

Basic Aspects of Intraepithelial Lymphocyte Immunobiology

1994 • 51 citations

Exquisite peptide specificity of oral tolerance in experimental autoimmune encephalomyelitis.

1995 • 50 citations

Activation of mucosal Vβ3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B

1993 • 48 citations

Involvement of α1 and α4 integrins in gut mucosal injury of graft-versus-host disease

1995 • 47 citations

CD2 expression on murine intestinal intraepithelial lymphocytes is bimodal and defines proliferative capacity

1993 • 47 citations

Expression of Endothelial Cell Adhesion Molecules in Joints and Heart duringBorrelia burgdorferiInfection of Mice

1994 • 45 citations

Differential contribution of the FcRγ chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcRγ‐deficient mice

1995 • 44 citations

Cytotoxic reactivity of gut lamina propria CD4⁺ αβ T cells in SCID mice with colitis

1996 • 43 citations

Heterogeneity and biased T cell receptor alpha/beta repertoire of mucosal CD8+ cells from murine large intestine: implications for functional state.

1994 • 42 citations

Production of cytokines by lymphocytes from spleen, mesenteric lymph node and intestinal lamina propria of pigs.

1994 • 41 citations

Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli.

1986 • 39 citations

Regional variation in the proliferative rate and lifespan of alpha beta TCR+ and gamma delta TCR+ intraepithelial lymphocytes in the murine small intestine.

1995 • 39 citations

Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice

1993 • 39 citations

Intraepithelial TcR alpha/beta+ lymphocytes express CD45RO more often than the TcR gamma/delta+ counterparts in coeliac disease.

1990 • 39 citations

Occurrence of Lymphocytes within the Gut Epithelium of Normal and Neonatally Thymectomized Mice

1968 • 38 citations

Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease

1990 • 37 citations

Human Gastrointestinal Mucosal T Cells

1994 • 37 citations

Tolerance of T cell receptor gamma/delta cells in the intestine.

1993 • 36 citations

Hormonal Regulation of Extrathymic Gut T Cell Development: Involvement of Thyroid Stimulating Hormone

1995 • 35 citations

Human intraepithelial lymphocytes

1990 • 35 citations

Immune deviation of 2C transgenic intraepithelial lymphocytes in antigen-bearing hosts.

1996 • 35 citations

Bystander suppression of the immune response to human serum albumin in rats fed ovalbumin.

1995 • 34 citations

Suppression of Murine Experimental Autoimmune Thyroiditis by Oral Administration of Porcine Thyroglobulin

1995 • 32 citations

Mucosal Adjuvants

1994 • 32 citations

Activated alpha beta-CD8+, but not alpha alpha-CD8+, TCR-alpha beta+ murine intestinal intraepithelial lymphocytes can mediate perforin-based cytotoxicity, whereas both subsets are active in Fas-based cytotoxicity.

1996 • 31 citations

Host intestinal intraepithelial γδ T lymphocytes present during acute graft‐versus‐host disease in mice may contribute to the development of enteropathy

1995 • 30 citations

The early appearance of specific cytotoxic T cells in murine gut mucosa.

1980 • 30 citations

Antigen processing in the mucosal immune system.

1992 • 30 citations

CD8 T-Cells Are Not Essential for the Induction of “Low-Dose” Oral Tolerance

1996 • 29 citations

Intraepithelial Lymphocytes and Their Recognition of Non-Classical MHC Molecules

1994 • 28 citations

Antigen‐presenting Function of the TL Antigen and Mouse CD1 Molecules

1995 • 26 citations

Immunohistochemical analysis of mucosal gamma-interferon production in coeliac disease.

1992 • 25 citations

Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine.

1992 • 24 citations

IL-1α Is Constitutively Expressed in the Rat Intestinal Epithelial Cell Line IEC-6

1995 • 21 citations

Diversity and Function of Antigen-Presenting Cells in Mucosal Tissues

1994 • 20 citations

A role for interleukin-1 alpha in immunologically mediated intestinal pathology.

1993 • 20 citations

Characteristics of fetal thymus‐derived T cell receptor γδ intestinal intraepithelial lymphocytes

1994 • 19 citations

IL-4 enhances IEC-6 intestinal epithelial cell proliferation yet has no effect on IL-6 secretion

1996 • 17 citations

A role for IL-4 in immunologically mediated enteropathy

1995 • 16 citations

Requirement for extrathymic class I histocompatibility antigens for positive selection of thymus-derived T lymphocytes.

1995 • 15 citations

Evidence against T‐cell development in the adult human intestinal mucosa based upon lack of terminal deoxynucleotidyltransferase expression

1996 • 14 citations

Regulatory Activity of Endogenous and Exogenous Transforming Growth Factor β in Experimental Intestinal Immunopathology

1996 • 14 citations

EVIDENCE THAT Ia+ BONE-MARROW-DERIVED CELLS ARE THE STIMULUS FOR THE INTESTINAL PHASE OF THE MURINE GRAFT-VERSUS-HOST REACTION

1986 • 13 citations

Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of FcεRlγ chain

1995 • 10 citations

Peyer's Patch Dendritic Cells: Isolation and Functional Comparison with Murine Spleen Dendritic Cells

1984 • 8 citations

Development of CD8α/β⁺ TCRαβ intestinal intraepithelial lymphocytes in athymic nu/nu mice and participation in regional immune responses

1996 • 8 citations

Stimulation Through CD50 Preferentially Induces Apoptosis of TCR1+ Human Peripheral Blood Lymphocytes

1998 • 8 citations

T-cell responses to enteric antigens.

1996 • 6 citations