A synergistic relationship between TNF-alpha, IL-1 beta, and TGF-beta 1 on IL-6 secretion by the IEC-6 intestinal epithelial cell line.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Interleukin-6 in Biology and Medicine

1993 • 1,398 citations

Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)

1990 • 1,307 citations

A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.

1995 • 1,205 citations

Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas.

1986 • 701 citations

Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis.

1991 • 546 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

The Role of Interleukin-6 in Mucosal IgA Antibody Responses in Vivo

1994 • 460 citations

Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β

1993 • 446 citations

Interleukins and IgA synthesis. Human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells.

1989 • 444 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Regulation of intestinal epithelial cell growth by transforming growth factor type beta.

1989 • 341 citations

Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

1992 • 325 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Effects of growth factors on an intestinal epithelial cell line: Transforming growth factor β inhibits proliferation and stimulates differentiation

1987 • 305 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

Inflammatory mediators of experimental colitis in rats

1989 • 264 citations

Evidence for an acute phase response in human intestinal epithelial cells

1993 • 245 citations

IL-1 and tumor necrosis factor synergistically stimulate fibroblast IL-6 production and stabilize IL-6 messenger RNA.

1990 • 242 citations

Transforming growth factor alpha and beta expression in human colon cancer lines: implications for an autocrine model.

1987 • 222 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

Cytokine regulation of interleukin 6 production by human endothelial cells

1989 • 176 citations

Interleukin-6 and its receptor are expressed in human intestinal epithelial cells

1989 • 150 citations

Human appendix B cells naturally express receptors for and respond to interleukin 6 with selective IgA1 and IgA2 synthesis.

1991 • 124 citations

Transforming growth factor-beta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6.

1993 • 110 citations

Colonic Mucosal Interleukin-6 in Inflammatory Bowel Disease

1991 • 104 citations

Interleukin 1β is expressed predominantly by enterocytes in experimental colitis

1991 • 96 citations

Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: mode of action and augmenting effect of inflammatory cytokines

1993 • 94 citations

Cytokine mRNA Expression in Intestine from Normal and Inflammatory Bowel Disease Patients

1993 • 80 citations

Characterization of the inhibitory effects of transforming growth factor-beta on a human colon carcinoma cell line.

1987 • 77 citations

Transforming growth factor-beta enhances interleukin-6 secretion by intestinal epithelial cells.

1992 • 70 citations

Expression of interleukin-6 by intestinal enterocytes.

1993 • 56 citations

Production of inflammatory cytokines in the intestinal lamina propria

1991 • 31 citations