Characteristics of fetal thymus‐derived T cell receptor γδ intestinal intraepithelial lymphocytes

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Gamma/Delta Cells

1993 • 819 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice

1980 • 551 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

CD8 is needed for development of cytotoxic T but not helper T cells

1991 • 528 citations

Intestinal intraepithelial lymphocytes are a distinct set of γδ T cells

1988 • 394 citations

Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells.

1984 • 272 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Phenotypic complexity of intraepithelial lymphocytes of the small intestine.

1991 • 252 citations

Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules.

1989 • 231 citations

Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes

1989 • 217 citations

Immunoregulatory functions for murine intraepithelial lymphocytes: gamma/delta T cell receptor-positive (TCR+) T cells abrogate oral tolerance, while alpha/beta TCR+ T cells provide B cell help.

1992 • 186 citations

The extrathymic T-cell development pathway

1992 • 169 citations

Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.

1992 • 163 citations

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes.

1986 • 154 citations

Estrogen administration activates extrathymic T cell differentiation in the liver.

1992 • 153 citations

Most gamma delta T cells develop normally in beta 2-microglobulin-deficient mice.

1992 • 147 citations

Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules

1990 • 145 citations

Intraepithelial Lymphocyte Count and Crypt Hyperplasia Measure the Mucosal Component of the Graft-versus-Host Reaction in Mouse Small Intestine

1982 • 142 citations

Athymic mice express a high level of functional γ-chain but greatly reduced levels of α- and β-chain T-cell receptor messages

1986 • 133 citations

Cytotoxic and interferon gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are strain dependent.

1993 • 98 citations

Peripheral engraftment of fetal intestine into athymic mice sponsors T cell development: direct evidence for thymopoietic function of murine small intestine.

1992 • 97 citations

Thymus influences the development of extrathymically derived intestinal intraepithelial lymphocytes

1993 • 86 citations

Diversity in T-cell receptor gamma gene usage in intestinal epithelium.

1989 • 83 citations

Expression of the CD28 costimulatory molecule on subsets of murine intestinal intraepithelial lymphocytes correlates with lineage and responsiveness

1993 • 80 citations

Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.

1993 • 80 citations

CD3⁻CD8⁺ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL

1994 • 78 citations

Thymus-grafted SCID mice show transient thymopoiesis and limited depletion of V beta 11+ T cells.

1992 • 69 citations

Repertoire Development and Ligand Specificity of Murine TCRγδ Cells

1991 • 64 citations

γδ T-cell development

1993 • 61 citations

Proliferative properties of murine intestinal intraepithelial lymphocytes (IEL): IEL expressing TCRαβ or TCRτδ are largely unresponsive to proliferative signals mediated via conventional stimulation of the CD3-TCR complex

1991 • 61 citations

A TCR Cell Recognizing a Novel TL-encoded Gene Product

1989 • 50 citations

Selective expression of CD8α (Ly‐2) subunit on activated thymic γ/δ cells

1990 • 47 citations

Selective death of T cell receptor γ/δ⁺ intraepithelial lymphocytes by apoptosis

1990 • 47 citations

Dominantly inherited expression of BID, an invariant undiversified T cell receptor δ chain

1990 • 43 citations

Age‐related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice

1993 • 39 citations

Presence of intestinal intraepithelial lymphocytes in mice with severe combined immunodeficiency disease

1990 • 37 citations

Tolerance of T cell receptor gamma/delta cells in the intestine.

1993 • 36 citations

Rearrangement and junctional-site sequence analyses of T-cell receptor gamma genes in intestinal intraepithelial lymphocytes from murine athymic chimeras.

1991 • 34 citations

Self-reactive, T cell receptor-gamma delta+, lymphocytes from the intestinal epithelium of weanling mice.

1992 • 31 citations

Extrathymic origin of V_γ1/V_δ6 T cells in the skin

1992 • 31 citations

Emigration of selected subsets of γδ⁺ T cells from the adult murine thymus

1993 • 29 citations

CD8 inhibits signal transduction through the T cell receptor in CD4-CD8- thymocytes from T cell receptor transgenic mice reconstituted with a transgenic CD8 alpha molecule.

1993 • 24 citations

Lymphokine secretion and proliferation of intraepithelial lymphocytes from murine small intestine.

1992 • 24 citations

EXAMINATION OF LYMPHOCYTE MEMBRANES OF ATHYMIC “NUDE” MICE BY SCANNING ELECTRON MICROSCOPY*

1975 • 5 citations

Ontogeny of the response of mouse thymocytes to interleukin 1 and interleukin 2

1991 • 3 citations