Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Oral Tolerance: Immunologic Mechanisms and Treatment of Animal and Human Organ-Specific Autoimmune Diseases by Oral Administration of Autoantigens

1994 • 895 citations

Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.

1991 • 562 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

1993 • 491 citations

Oral tolerance.

1994 • 456 citations

Recombinant Human IL-10 Prevents the Onset of Diabetes in the Nonobese Diabetic Mouse

1994 • 429 citations

Immunoregulatory and Cytokine Imbalances in the Pathogenesis of IDDM: Therapeutic Intervention by Immunostimulation?

1994 • 363 citations

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

1990 • 349 citations

Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process.

1994 • 300 citations

Increased expression of IL-4 and IL-10 and decreased expression of IL-2 and interferon-gamma in long-surviving mouse heart allografts after brief CD4-monoclonal antibody therapy.

1995 • 175 citations

Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression.

1993 • 158 citations

Altered Cytokine Activity in Adjuvant Inhibition of Autoimmune Diabetes

1993 • 151 citations

Oral Administration of Human Insulin to NOD Mice Generates CD4+ T Cells that Suppress Adoptive Transfer of Diabetes

1994 • 137 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

CD8 T Cells Are Not Required for Islet Destruction Induced by a CD4+ Islet-Specific T-Cell Clone

1992 • 69 citations

Evidence of CD4 + regulatory T cells in the non-obese diabetic male mouse

1994 • 55 citations