The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

A Short-Term Study of Chimeric Monoclonal Antibody cA2 to Tumor Necrosis Factor α for Crohn's Disease

1997 • 3,152 citations

Leukocyte-endothelial adhesion molecules

1994 • 2,567 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Leukocyte-endothelial adhesion molecules

1994 • 1,884 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

1999 • 1,325 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Inflammatory Bowel Disease

1991 • 1,264 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

TRAF2-Mediated Activation of NF-κB by TNF Receptor 2 and CD40

1995 • 1,046 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Two tumour necrosis factor receptors: structure and function

1995 • 800 citations

Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis

1991 • 794 citations

Tumor necrosis factor identified in multiple sclerosis brain.

1989 • 793 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2

1996 • 715 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

1996 • 602 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

Immunoregulatory role of interleukin 10 in rheumatoid arthritis.

1994 • 531 citations

Tumour necrosis factor and Crohn's disease.

1997 • 504 citations

Tumor necrosis factors: developments during the last decade.

1996 • 473 citations

The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor

1998 • 463 citations

Production of cytotoxic factor for oligodendrocytes by stimulated astrocytes.

1987 • 426 citations

Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice

1997 • 422 citations

Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4

1998 • 411 citations

Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor alpha.

1995 • 407 citations

Reciprocal IFN-γ and TGF-β responses regulate the occurrence of mucosal inflammation

1997 • 399 citations

A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease.

1997 • 391 citations

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

1995 • 383 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

Oligodendrocyte Apoptosis and Primary Demyelination Induced by Local TNF/p55TNF Receptor Signaling in the Central Nervous System of Transgenic Mice

1998 • 317 citations

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor.

1993 • 297 citations

Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis

1995 • 296 citations

Chronic Tumor Necrosis Factor Alters T Cell Responses by Attenuating T Cell Receptor Signaling

1997 • 287 citations

The potential biological and clinical significance of the soluble tumor necrosis factor receptors

1996 • 284 citations

TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation.

1996 • 283 citations

Transducing signals of life and death

1997 • 275 citations

Serum concentrations of inflammatory mediators related to organ failure in patients with acute pancreatitis

1996 • 265 citations

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1997 • 255 citations

T Lymphocytes in Collagen II‐Induced Arthritis in Mice

1985 • 253 citations

Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting

1997 • 239 citations

Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor‐immunoglobulin fusion proteins

1994 • 232 citations

Circulating levels of tumor necrosis factor soluble receptors in systemic lupus erythematosus are significantly higher than in other rheumatic diseases and correlate with disease activity.

1997 • 230 citations

Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling.

1996 • 217 citations

The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease

1999 • 210 citations

Mononuclear cells from infants allergic to cow's milk secrete tumor necrosis factor α, altering intestinal function

1994 • 205 citations

Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice.

1996 • 203 citations

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

1999 • 201 citations

Local Expression of TNFα in Neonatal NOD Mice Promotes Diabetes by Enhancing Presentation of Islet Antigens

1998 • 195 citations

Endogenous Myelin Basic Protein Inactivates the High Avidity T Cell Repertoire

1998 • 188 citations

Differential Tolerance Is Induced in T Cells Recognizing Distinct Epitopes of Myelin Basic Protein

1998 • 182 citations

Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane‐bound TNF in experimental cerebral malaria

1997 • 182 citations

Low levels of interleukin‐4 and high levels of transforming growth factor β in rheumatoid synovitis

1990 • 181 citations

In vivo evidence for a functional role of both tumor necrosis factor (TNF) receptors and transmembrane TNF in experimental hepatitis

1997 • 176 citations

Challenging Cytokine Redundancy: Inflammatory Cell Movement and Clinical Course of Experimental Autoimmune Encephalomyelitis Are Normal in Lymphotoxin-deficient, but Not Tumor Necrosis Factor–deficient, Mice

1998 • 170 citations

The type I interleukin‐1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF‐transgenic mice

1995 • 159 citations

IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice.

1998 • 153 citations

The Pathophysiology Of Tumor Necrosis Factors

1992 • 153 citations

A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into scid mice

1994 • 152 citations

Depressed Langerhans cell migration and reduced contact hypersensitivity response in mice lacking TNF receptor p75.

1997 • 152 citations

Human Tumor Necrosis Factor Receptor p75/80 (CD120b) Gene Structure and Promoter Characterization

1996 • 144 citations

DIFFERENT ROLES OF TUMOUR NECROSIS FACTOR α AND INTERLEUKIN 1 IN MURINE STREPTOCOCCAL CELL WALL ARTHRITIS

1998 • 143 citations

Early mucosal changes in Crohn's disease.

1993 • 136 citations

Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line

1997 • 132 citations

A Critical Role of the p75 Tumor Necrosis Factor Receptor (p75TNF-R) in Organ Inflammation Independent of TNF, Lymphotoxin α, or the p55TNF-R

1998 • 129 citations

A p55 TNF Receptor Immunoadhesin Prevents T Cell-Mediated Intestinal Injury by Inhibiting Matrix Metalloproteinase Production

1998 • 128 citations

Tumor necrosis factor receptors in patients with chronic hepatitis B virus infection

1995 • 127 citations

Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo

1996 • 124 citations

Collagen-induced arthritis in CD4- or CD8-deficient mice: CD8+ T cells play a role in initiation and regulate recovery phase of collagen-induced arthritis.

1996 • 124 citations

Antiviral Activity of Tumor Necrosis Factor (TNF) Is Mediated via p55 and p75 TNF Receptors

1997 • 119 citations

Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration.

1993 • 115 citations

Shedding kinetics of soluble tumor necrosis factor (TNF) receptors after systemic TNF leaking during isolated limb perfusion. Relevance to the pathophysiology of septic shock.

1998 • 114 citations

Control of IL-12 and IFN-gamma production in response to live or dead bacteria by TNF and other factors.

1998 • 112 citations

Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis.

1995 • 108 citations

Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

1995 • 107 citations

TNF-induced enterocyte apoptosis in mice is mediated by the TNF receptor 1 and does not require p53

1998 • 106 citations

Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response.

1997 • 104 citations

Therapy against murine collagen‐induced arthritis with T cell receptor V_β‐specific antibodies

1991 • 102 citations

Treatment of ulcerative colitis in the cottontop tamarin using antibody to tumour necrosis factor alpha.

1997 • 97 citations

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

1999 • 93 citations

Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes.

1993 • 90 citations

Control ofLeishmania majorInfection in Mice Lacking TNF Receptors

1998 • 88 citations

Anti‐T cell receptor antibody treatment of rats with established autologous collagen‐induced arthritis: suppression of arthritis without reduction of anti‐type II collagen autoantibody levels

1991 • 81 citations

Pattern of soluble TNF receptors I and II in sepsis

1995 • 79 citations

TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria

1997 • 78 citations

Defective co-stimulation and impaired Th1 development in tumor necrosis factor/lymphotoxin-alpha double-deficient mice infected with Candida albicans

1998 • 72 citations

The role of TNFα and related cytokines in the development and function of the autoreactive T-cell repertoire

1997 • 70 citations

TNF inhibition and sepsis — sounding a cautionary note

1997 • 70 citations

Modulation of proinflammatory cytokine production in tumour necrosis factor-alpha (TNF-α)-transgenic mice by treatment with cells engineered to secrete IL-4, IL-10 or IL-13

1998 • 70 citations

Mice Lacking Mature T and B Lymphocytes Develop Arthritic Lesions after Immunization with Type II Collagen

1999 • 66 citations

Stimulation of human synovial fibroblast DNA synthesis by recombinant human cytokines.

1988 • 64 citations

Regulatory roles of tumor necrosis factor-alpha and interleukin-1 beta in monocyte chemoattractant protein-1-mediated pulmonary granuloma formation in the rat.

1995 • 58 citations

Inhibition of Th1 Polarization by Soluble TNF Receptor Is Dependent on Antigen-Presenting Cell-Derived IL-12

1999 • 58 citations

Mucosal Immunoregulation and Inflammatory Bowel Disease: New Insights from Murine Models of Inflammation

1998 • 57 citations

Synergistic effect of interleukin‐1β and tumor necrosis factor α on interleukin‐8 gene expression in synovial fibroblasts. evidence that interleukin‐8 is the major neutrophil‐activating chemokine released in response to monokine activation

1993 • 55 citations

A double‐blind, placebo‐controlled study of anti‐CD5 immunoconjugate in patients with rheumatoid arthritis

1996 • 53 citations

HLA-D and IA antigens in rheumatoid arthritis and systemic lupus erythematosus

1978 • 52 citations

Inflammatory bowel disease

1992 • 50 citations

Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse

1995 • 48 citations

Upregulation of NF-κB-Dependent Gene Expression Mediated by the p75 Tumor Necrosis Factor Receptor

1995 • 39 citations

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

1999 • 36 citations

Effects of anti‐CD4 antibody treatment on lymphocyte subsets and stimulated tumor necrosis factor alpha production

1997 • 34 citations

Induction of myelin basic protein-specific experimental autoimmune encephalomyelitis in C57BL/6 mice: Mapping of T cell epitopes and T cell receptor V? gene segment usage

1996 • 33 citations

High plasma level of soluble tumor necrosis factor receptor type II (sTNFRII) in asymptomatic HIV-1-infected patients

1996 • 19 citations

Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1

1999 • 17 citations

A tumor necrosis factor-induced model of human primary demyelinating diseases develops in immunodeficient mice

1999 • 15 citations

Modulation of the transcripts for tumor necrosis factor‐α and its receptors in vivo

1994 • 14 citations

TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis

1999 • 5 citations