The potential biological and clinical significance of the soluble tumor necrosis factor receptors

Elevated Circulating Levels of Tumor Necrosis Factor in Severe Chronic Heart Failure

1990 • 2,566 citations

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor α (cA2) versus placebo in rheumatoid arthritis

1994 • 1,695 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Macrophage-induced angiogenesis is mediated by tumour necrosis factor-α

1987 • 1,210 citations

Septic Shock in Humans

1990 • 1,170 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

Two TNF receptors

1992 • 1,048 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists.

1993 • 837 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

Interleukin-6 (IL-6) as an anti-inflammatory cytokine: induction of circulating IL-1 receptor antagonist and soluble tumor necrosis factor receptor p55

1994 • 799 citations

Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo.

1985 • 788 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Tumour necrosis factor alpha in stool as a marker of intestinal inflammation

1992 • 700 citations

Fibroblast growth enhancing activity of tumor necrosis factor and its relationship to other polypeptide growth factors.

1986 • 674 citations

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

1994 • 578 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

Two tumor necrosis factor-binding proteins purified from human urine. Evidence for immunological cross-reactivity with cell surface tumor necrosis factor receptors.

1990 • 557 citations

Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart Failure

1995 • 534 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Elevated tumour necrosis factor-alpha (TNF-α) biological activity in psoriatic skin lesions

1994 • 481 citations

Tumor necrosis factors: developments during the last decade.

1996 • 473 citations

Requirement of endogenous tumor necrosis factor/cachectin for recovery from experimental peritonitis.

1990 • 447 citations

A tumor necrosis factor-binding protein purified to homogeneity from human urine protects cells from tumor necrosis factor toxicity

1989 • 442 citations

Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases

1992 • 341 citations

A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.

1991 • 326 citations

Soluble receptors for tumour necrosis factor in clinical laboratory diagnosis

1995 • 296 citations

Purification and biologic characterization of a specific tumor necrosis factor α inhibitor

1989 • 294 citations

Tumor necrosis factor, interleukin-1, and interleukin-6 in normal human pregnancy

1993 • 283 citations

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.

1991 • 279 citations

Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis

1991 • 275 citations

A metalloprotease inhibitor blocks shedding of the IL-6 receptor and the p60 TNF receptor.

1995 • 254 citations

Isolation and characterization of a tumor necrosis factor binding protein from urine

1989 • 249 citations

Recombinant soluble tumor necrosis factor receptor proteins protect mice from lipopolysaccharide‐induced lethality

1991 • 239 citations

Increased serum levels of soluble receptors for tumor necrosis factor in cancer patients.

1991 • 234 citations

A metalloprotease inhibitor blocks shedding of the 80-kD TNF receptor and TNF processing in T lymphocytes.

1995 • 234 citations

Shedding from the Cell Surface of Normal and Cancer Cells

1980 • 215 citations

T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptor

1991 • 215 citations

Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils.

1991 • 193 citations

Cowpox Virus Contains Two Copies of an Early Gene Encoding a Soluble Secreted Form of the Type II TNF Receptor

1994 • 177 citations

Correlation between serum levels of soluble tumor necrosis factor receptor and disease activity in systemic lupus erythematosus

1993 • 177 citations

Infusion of tumor necrosis factor (TNF) causes an increase in circulating TNF-binding protein in humans

1990 • 176 citations

Protective effect of 55- but not 75-kD soluble tumor necrosis factor receptor-immunoglobulin G fusion proteins in an animal model of gram-negative sepsis.

1994 • 174 citations

Isolation and characterization of eight tumor necrosis factor-induced gene sequences from human fibroblasts.

1990 • 158 citations

Cells secreting tumour necrosis factor show enhanced metastasis in nude mice

1990 • 154 citations

Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group

1995 • 153 citations

Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging

1995 • 150 citations

Cytokines in Acute Myocardial Infarction

1994 • 149 citations

Variation in serum levels of the soluble TNF receptors among healthy individuals.

1992 • 145 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

Soluble tumor necrosis factor receptors in human inflammatory synovial fluids

1993 • 129 citations

Soluble Receptors for Tumor Necrosis Factor as Predictors of Progression to AIDS in Asymptomatic Human Immunodeficiency Virus Type 1 Infection

1994 • 113 citations

Soluble Tumor Necrosis Factor Receptors Correlate with Parasitemia and Disease Severity in Human Malaria

1992 • 106 citations

Tumor necrosis factor bifunctionally regulates matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP) production by human fibroblasts

1990 • 103 citations

Tumor necrosis factor expression in human epithelial tumor cell lines.

1988 • 102 citations

Patterns of Proinflammatory Cytokines and Inhibitors during Typhoid Fever

1994 • 101 citations

Paradoxical effects of tumour necrosis factor in experimental ovarian cancer

1989 • 94 citations

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

1989 • 90 citations

Tumor necrosis factor: receptors and inhibitors.

1991 • 90 citations

Serum levels of p60 soluble tumor necrosis factor receptor during acute Kawasaki disease

1994 • 83 citations

Circulating interleukin-1 and tumor necrosis factor antagonists in liver disease

1993 • 74 citations

In situ detection of tumour necrosis factor in human ovarian cancer specimens

1990 • 70 citations

Adherence of neutrophils induces release of soluble tumor necrosis factor receptor forms.

1994 • 64 citations

TRAUMA CAUSES EARLY RELEASE OF SOLUBLE RECEPTORS FOR TUMOR NECROSIS FACTOR

1993 • 62 citations

Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis.

1990 • 61 citations

Tumor necrosis factor: molecular and cellular biology and clinical relevance

1994 • 59 citations

Evaluation of soluble tumor necrosis factor (TNF) receptors and TNF receptor antibodies in patients with systemic lupus erythematodes, progressive systemic sclerosis, and mixed connective tissue disease

1993 • 55 citations

Interleukin-1 beta induces interleukin-1 receptor antagonist and tumor necrosis factor binding protein in humans.

1993 • 54 citations

Tumor necrosis factor alpha and soluble tumor necrosis factor receptors in individuals with human immunodeficiency virus infection

1994 • 53 citations

Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.

1995 • 52 citations

Serum cytokine levels in patients undergoing bone marrow transplantation.

1993 • 49 citations

Tumor necrosis factor: Molecular and cellular biology and clinical relevance

1995 • 45 citations

Tumor Necrosis Factor and Cardiac Function

1992 • 44 citations

Bioactive human recombinant tumor necrosis factor‐α: an unstable dimer?

1989 • 40 citations

Therapeutic efficacy of recombinant tumor necrosis factor alpha in an experimental model of human prostatic carcinoma.

1990 • 38 citations

Distinct tumor cell membrane constituents activate human monocytes for tumor necrosis factor synthesis.

1990 • 38 citations

Stabilisation of functional tumor necrosis factor-alpha by its soluble TNF receptors.

1993 • 37 citations

Circulating tumor necrosis factor alpha (TNF), soluble TNF receptors, and interleukin-6 in human subacute bacterial endocarditis

1993 • 37 citations

Soluble tumor necrosis factor receptors and soluble interleukin-6 receptor in fetal and maternal sera, coelomic and amniotic fluids in normal and pre-eclamptic pregnancies

1995 • 35 citations

Serum-Soluble Receptors for Tumor Necrosis Factor-α and Interleukin-2, and Neopterin in Acute Rheumatic Fever

1995 • 32 citations

Increased levels of soluble interleukin-2 receptors and tumor necrosis factor in serum of patients with myelodysplastic syndromes [letter] [see comments]

1991 • 28 citations

Complement activation and release of tumour necrosis factor alpha, interleukin-2, interleukin-6 and soluble tumour necrosis factor and interleukin-2 receptors during and after cardiopulmonary bypass in children

1995 • 28 citations

Soluble tumour necrosis factor receptors, tumour necrosis factor and interleukin‐6 in serum in granulocytopenic patients with fever

1995 • 24 citations

Increased Concentrations of Soluble Tumor Necrosis Factor Receptor 75 but Not of Soluble Intercellular Adhesion Molecule-1 Are Associated with the Decline of CD4+ Lymphocytes in HIV Infection

1994 • 23 citations

Assessment of a Possible Imbalance between Tumor Necrosis Factor (TNF) and Soluble TNF Receptor Forms in Tuberculous Infection of the Central Nervous System

1995 • 22 citations

Induction of soluble tumour necrosis factor receptors during treatment with interleukin-2

1992 • 20 citations

Soluble Receptors for Tumor Necrosis Factor as Markers of Disease Activity in Visceral Leishmaniasis

1995 • 17 citations

IS 24 h AMBULATORY OESOPHAGEAL pH MONITORING USEFUL IN A DISTRICT GENERAL HOSPITAL?

1987 • 17 citations

Elevated Levels of Soluble Interleukin 2 Receptor and Tumor Necrosis Factor in Nasopharyngeal Carcinoma

1991 • 16 citations

Leukemic cells in hairy cell leukemia and B cell chronic lymphocytic leukemia release soluble TNF receptors.

1995 • 14 citations

Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells

1995 • 13 citations

Pharmacokinetics and tissue distribution of human urinary tumor necrosis factor binding protein in mice.

1992 • 11 citations

Soluble Tumor Necrosis Factor Receptors in Health and Disease

2015 • 9 citations

High Levels of Soluble p55-TNF Receptors in Seminal and Prostatic Fluids of Normal and Infertile Men

1996 • 3 citations