Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice.

VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/Fibronectin binding site

1990 • 1,836 citations

Apoptosis in rheumatoid arthritis synovium.

1995 • 378 citations

Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues.

1991 • 295 citations

Molecular and cellular mechanisms of joint destruction in rheumatoid arthritis: two cellular mechanisms explain joint destruction?

1993 • 272 citations

Pannus and pannocytes

1994 • 224 citations

Collagenase at Sites of Cartilage Erosion in the Rheumatoid Joint

1977 • 218 citations

Histomorphological Basis of Articular Cartilage Destruction in Rheumatoid Arthritis

1983 • 195 citations

A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into scid mice

1994 • 152 citations

Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis

1991 • 152 citations

The VLA-4/VCAM-1 pathway is involved in lymphocyte adhesion to endothelium in rheumatoid synovium.

1991 • 147 citations

Susceptibility of the cartilage collagens types II, IX and XI to degradation by the cysteine proteinases, cathepsins B and L

1990 • 147 citations

Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature.

1994 • 138 citations

Expression of the Collagenolytic and Ras-Induced Cysteine Proteinase Cathepsin L and Proliferation-Associated Oncogenes in Synovial Cells of MRL/I Mice and Patients with Rheumatoid Arthritis

1990 • 134 citations

Mechanisms of Matrix Degradation in Rheumatoid Arthritis^a

1990 • 132 citations

ONCOGENES IN RHEUMATOID ARTHRITIS

1995 • 104 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 97 citations

Cartilage proteoglycan aggregate is degraded more extensively by cathepsin L than by cathepsin B.

1990 • 94 citations

Overexpression of zinc-finger transcription factor Z-225/Egr-1 in synoviocytes from rheumatoid arthritis patients.

1994 • 86 citations

Expression of vascular cell adhesion molecule-1 mRNA and protein in rheumatoid synovium demonstrated by in situ hybridization and immunohistochemistry.

1995 • 85 citations

Comparative analysis of cathepsin l, cathepsin d, and collagenase messenger rna expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization

1995 • 81 citations

Monoclonal antibodies to human prolyl 4-hydroxylase

1984 • 78 citations

Localization of collagenase mRNA in rheumatoid arthritis synovium byin situ hybridization histochemistry

1990 • 73 citations

Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes.

1993 • 53 citations

Demonstration of granzyme A and perforin messenger RNA in the synovium of patients with rheumatoid arthritis

1995 • 53 citations

Survival of rheumatoid synovium implanted into nude mice.

1981 • 49 citations

Characterization and isolation of poly- and monoclonal antibodies against collagen for use in immunohistochemistry

1987 • 41 citations

Stromelysin and tissue inhibitor of metalloproteinases gene expression in rheumatoid arthritis synovium.

1992 • 23 citations

Augmented excretion of procathepsin L of a fos-transferred highly metastatic rat cell line

1990 • 22 citations

Synovial fibroblast-like cell transfection with the SV40 large T antigen induces a transformed phenotype and permits transient tumor formation in immunodeficient mice.

1994 • 14 citations

T cell-independent cellular pathways of rheumatoid joint destruction

1995 • 10 citations