Double‐blind, placebo‐controlled multicenter trial using chimeric monoclonal anti‐cd4 antibody, cm‐t412, in rheumatoid arthritis patients receiving concomitant methotrexate

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis

1988 • 19,632 citations

THERAPEUTIC CRITERIA IN RHEUMATOID ARTHRITIS

1949 • 2,904 citations

The shared epitope hypothesis. an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis

1987 • 2,539 citations

Association of the B-Cell Alloantigen DRw4 with Rheumatoid Arthritis

1978 • 1,170 citations

Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy

1995 • 1,066 citations

Mouse/human chimeric monoclonal antibody in man: kinetics and immune response.

1989 • 526 citations

AGEING, IMMUNE RESPONSE, AND MORTALITY

1974 • 480 citations

Predominantly T-Cell Infiltrate in Rheumatoid Synovial Membranes

1975 • 387 citations

Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4.

1985 • 372 citations

HLA Genes associated with rheumatoid Arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

1989 • 345 citations

Reversal of Experimental Allergic Encephalomyelitis with Monoclonal Antibody to a T-Cell Subset Marker

1985 • 328 citations

Humanised monoclonal antibody therapy for rheumatoid arthritis

1992 • 316 citations

Ia+ T Cells in Synovial Fluid And Tissues of Patients with Rheumatoid Arthritis

1981 • 296 citations

Treatment of rheumatoid arthritis with an anti‐CD4 monoclonal antibody

1991 • 279 citations

Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis

1990 • 236 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4.

1987 • 211 citations

Lymphocyte Involvement in Rheumatoid Arthritis

1977 • 198 citations

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1995 • 194 citations

Association of HLA-Aw31 and HLA-DR1 with adult rheumatoid arthritis.

1982 • 168 citations

Anti-CD4 antibody treatment of patients with rheumatoid arthritis: I. Effect on clinical course and circulating T cells

1989 • 143 citations

Treatment of rheumatoid arthritis with monoclonal CD4 antibody M‐T151. Clinical results and immunopharmacologic effects in an open study, including repeated administration

1991 • 136 citations

Immunotherapy for myasthenia gravis: a murine model.

1986 • 125 citations

Use of a chimeric monoclonal anti‐CD4 antibody in patients with refractory rheumatoid arthritis

1993 • 120 citations

Treatment of refractory rheumatoid arthritis with a chimeric ANTI‐CD4 monoclonal antibody

1994 • 118 citations

Preventive effect of monoclonal anti-L3T4 antibody on development of diabetes in NOD mice

1987 • 96 citations

Treatment of murine lupus with F(ab')2 fragments of monoclonal antibody to L3T4. Suppression of autoimmunity does not depend on T helper cell depletion.

1989 • 88 citations

Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells.

1988 • 84 citations

Efficacy of Total Lymphoid Irradiation in Intractable Rheumatoid Arthritis

1985 • 78 citations

Chimeric cd4 monoclonal antibody cm‐t412 as a therapeutic approach to rheumatoid arthritis

1993 • 76 citations

Therapeutic use of monoclonal anti-CD4 antibody in rheumatoid arthritis.

1991 • 71 citations

Immunological effects of high dose administration of anti-CD4 antibody in rheumatoid arthritis patients

1991 • 70 citations

Administration of F(ab')2 fragments of monoclonal antibody to L3T4 inhibits humoral immunity in mice without depleting L3T4+ cells.

1986 • 67 citations

Inhibition of autoimmune uveitis by anti-CD4 antibody.

1990 • 58 citations

Development of murine lupus in CD4-depleted NZB/NZW mice. Sustained inhibition of residual CD4+ T cells is required to suppress autoimmunity.

1992 • 56 citations

Phase 1 clinical trial of chimeric monoclonal anti‐CD4 antibody in multiple sclerosis

1994 • 52 citations

Rheumatoid arthritis complicated by infection with the human immunodeficiency virus and the development of Sjögren's syndrome

1989 • 48 citations

Treatment of rats with monoclonal anti‐CD4 induces long‐term resistance to streptococcal cell wall‐induced arthritis

1992 • 44 citations

Human anti-mouse antibody response induced by anti-CD4 monoclonal antibody therapy in patients with rheumatoid arthritis

1991 • 41 citations

Do nonimmunologically mediated pathways play a role in the pathogenesis of rheumatoid arthritis?

1993 • 29 citations

Pristane induced arthritis in mice. IV. Immunotherapy with monoclonal antibodies directed against lymphocyte subsets.

1992 • 29 citations

Effects of Early and Late Treatment with Anti-CD4 Monoclonal Antibody on Autoimmune Disease in MRL/MP-Ipr/Ipr Mice

1994 • 27 citations

Effect of anti-CD4 antibody treatment on inflammatory arthritis in mice

1992 • 26 citations

Suppression in murine experimental autoimmune thyroiditis: In vivo inhibition of CD4+ T cell-mediated resistance by a nondepleting rat CD4 monoclonal antibody

1991 • 26 citations

Response of immunoregulatory lymphocyte subsets to methotrexate in rheumatoid arthritis

1990 • 20 citations

DO NONIMMUNOLOGICALLY MEDIATED PATHWAYS PLAY A ROLE IN THE PATHOGENESIS OF RHEUMATOID ARTHRITIS?

1993 • 20 citations

Comparative effects on the immune system of methotrexate and trimetrexate

1987 • 19 citations

Age Influences Recovery of Systemic and Mucosal Immune Responses Following Acute Depletion of CD4 T Cells

1993 • 15 citations

Treatment with anti‐cd4 monoclonal antibody and acute interstitial nephritis

1993 • 13 citations