Different activation forms of MMP-2 oppositely affect the fate of endothelial cells

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 4,109 citations

Structure and function of matrix metalloproteinases and TIMPs

2006 • 3,132 citations

Specificity and mechanism of action of some commonly used protein kinase inhibitors

2000 • 3,002 citations

Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts

1990 • 428 citations

Metalloproteinases and their inhibitors in tumor angiogenesis

2005 • 300 citations

Human endothelial gelatinases and angiogenesis

2001 • 294 citations

Mechanisms of Endothelial Dysfunction, Injury, and Death

2008 • 252 citations

Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)

2002 • 238 citations

Purification and catalytic properties of human caspase family members

1999 • 231 citations

Processing, shedding, and endocytosis of membrane type 1‐matrix metalloproteinase (MT1‐MMP)

2004 • 189 citations

Phosphorylation of p38 Mitogen-Activated Protein Kinase Downstream of Bax-Caspase-3 Pathway Leads to Cell Death Induced by High <scp>d</scp>-Glucose in Human Endothelial Cells

2001 • 160 citations

Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells

2005 • 141 citations

Differential Regulation of Membrane Type 1-Matrix Metalloproteinase Activity by ERK 1/2- and p38 MAPK-modulated Tissue Inhibitor of Metalloproteinases 2 Expression Controls Transforming Growth Factor-β1-induced Pericellular Collagenolysis

2004 • 133 citations

p38 MAPK mediates TNF-induced apoptosis in endothelial cells via phosphorylation and downregulation of Bcl-xL

2004 • 130 citations

Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM

2008 • 110 citations

Inhibition of programmed cell death impairs in vitro vascular‐like structure formation and reduces in vivo angiogenesis

2002 • 105 citations

Hypoxia of endothelial cells leads to MMP-2-dependent survival and death

2005 • 88 citations

Apoptosis of human hepatic myofibroblasts promotes activation of matrix metalloproteinase-2

2002 • 80 citations

p38 MAPK inhibition is critically involved in VEGFR-2-mediated endothelial cell survival

2003 • 77 citations

Activation of metalloproteinases and their association with integrins: an auxiliary apoptotic pathway in human endothelial cells

2002 • 71 citations

TIMP Independence of Matrix Metalloproteinase (MMP)-2 Activation by Membrane Type 2 (MT2)-MMP Is Determined by Contributions of Both the MT2-MMP Catalytic and Hemopexin C Domains

2006 • 69 citations

MAPK signaling regulates endothelial cell assembly into networks and expression of MT1-MMP and MMP-2

2004 • 59 citations

Active matrix metalloproteinase‐2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N‐cadherin

2009 • 55 citations

New Insights into the Function and Regulation of Endothelial Cell Apoptosis

2003 • 49 citations

Nitric oxide and p38 MAP kinase mediate shear stress‐dependent inhibition of MMP‐2 production in microvascular endothelial cells

2006 • 49 citations

Matrix Metalloproteinase‐2 Expression and Apoptogenic Activity in Retinal Pericytes

2007 • 43 citations

Modulation of phorbol ester—induced regulation of matrix metalloproteinases and tissue inhibitors of metalloproteinases by SB203580, a specific inhibitor of p38 mitogen-activated protein kinase

2002 • 41 citations

Apoptosis Causes Lumen Formation during Angiogenesis in Vitro

2002 • 37 citations

Hypoxia induces apoptosis of HUVECs in an in vitro capillary model by activating proapoptotic signal p38 through suppression of ERK1/2

2007 • 34 citations

Hypoxia‐induced apoptosis and tube breakdown are regulated by p38 MAPK but not by caspase cascade in an in vitro capillary model composed of human endothelial cells

2007 • 32 citations

MT1-MMP-Dependent and -Independent Regulation of Gelatinase A Activation in Long-Term, Ascorbate-Treated Fibroblast Cultures: Regulation by Fibrillar Collagen

2002 • 27 citations

Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathway

2007 • 7 citations