Astrocyte–endothelial interactions at the blood–brain barrier

The Blood-Brain Barrier/Neurovascular Unit in Health and Disease

2005 • 2,454 citations

Neurovascular regulation in the normal brain and in Alzheimer's disease

2004 • 2,069 citations

Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling

1990 • 1,820 citations

Mechanisms, challenges and opportunities in stroke

2003 • 1,688 citations

Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation

2002 • 1,399 citations

New roles for astrocytes: Redefining the functional architecture of the brain

2003 • 1,283 citations

Tight junctions of the blood–brain barrier

2002 • 1,108 citations

Astrocyte–endothelial interactions and blood–brain barrier permeability*

2002 • 1,098 citations

CXCR4-activated astrocyte glutamate release via TNFα: amplification by microglia triggers neurotoxicity

2001 • 1,024 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

Neurovascular mechanisms of Alzheimer's neurodegeneration

2005 • 903 citations

Blood-Brain Barrier in Physiology and Medicine

1976 • 888 citations

Potassium buffering in the central nervous system

2004 • 787 citations

Inflammatory mediators and modulation of blood-brain barrier permeability.

2000 • 769 citations

Connexins regulate calcium signaling by controlling ATP release

1998 • 767 citations

A cell culture model of the blood-brain barrier.

1991 • 753 citations

Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

2004 • 748 citations

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

2001 • 742 citations

Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction

2005 • 738 citations

Electrical resistance across the blood‐brain barrier in anaesthetized rats: a developmental study.

1990 • 736 citations

Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction

2005 • 712 citations

Intracellular calcium oscillations in astrocytes: a highly plastic, bidirectional form of communication between neurons and astrocytes in situ.

1997 • 711 citations

The molecular basis of water transport in the brain

2003 • 709 citations

BLOOD-BRAIN BARRIER DRUG TARGETING: THE FUTURE OF BRAIN DRUG DEVELOPMENT

2003 • 683 citations

Blood–brain barrier dysfunction in parkinsonian midbrain in vivo

2005 • 681 citations

GLIA: A novel drug discovery target for clinical pain

2003 • 661 citations

Intracellular Calcium Oscillations in Astrocytes: A Highly Plastic, Bidirectional Form of Communication between Neurons and AstrocytesIn Situ

1997 • 626 citations

Blood-brain barrier disruption in multiple sclerosis

2003 • 617 citations

The neurobiology of glia in the context of water and ion homeostasis

2004 • 587 citations

Physiology of the CSF and Blood-Brain Barriers

1996 • 569 citations

Vascular protection by dietary polyphenols

2004 • 565 citations

Signaling at the Gliovascular Interface

2003 • 562 citations

An Easier, Reproducible, and Mass‐Production Method to Study the Blood–Brain Barrier In Vitro

1990 • 534 citations

Development of the blood-brain barrier

1990 • 533 citations

Blood-Brain Barrier Transport of Cytokines: A Mechanism for Neuropathology

2005 • 476 citations

A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology

2002 • 466 citations

SSeCKS regulates angiogenesis and tight junction formation in blood-brain barrier

2003 • 458 citations

Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme

2000 • 456 citations

Dynamics of CNS Barriers: Evolution, Differentiation, and Modulation

2005 • 433 citations

Localization of claudin-3 in tight junctions of the blood-brain barrier is selectively lost during experimental autoimmune encephalomyelitis and human glioblastoma multiforme

2003 • 431 citations

Transporting therapeutics across the blood-brain barrier

1996 • 429 citations

The impact of systemic infection on the progression of neurodegenerative disease

2003 • 424 citations

Structural and functional aspects of the blood-brain barrier

2003 • 423 citations

Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells

2003 • 419 citations

Molecular mechanisms of cerebrospinal fluid production

2004 • 416 citations

Blood–Brain Barrier in Physiology and Medicine

1977 • 395 citations

Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis

1999 • 367 citations

Dietary proanthocyanidins: Occurrence, dietary intake, bioavailability, and protection against cardiovascular disease

2005 • 356 citations

Brain pericytes contribute to the induction and up-regulation of blood–brain barrier functions through transforming growth factor-β production

2005 • 324 citations

A pericyte‐derived angiopoietin‐1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie‐2 activation in vitro

2004 • 316 citations

Glial neuronal signaling in the central nervous system

2003 • 306 citations

Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells

2005 • 303 citations

Blood–brain barrier breakdown in septic encephalopathy and brain tumours*

2002 • 299 citations

In Search of the Astrocytic Factor(s) Modulating Blood–Brain Barrier Functions in Brain Capillary Endothelial Cells In Vitro

2005 • 292 citations

Long-Term Vitamin C Treatment Increases Vascular Tetrahydrobiopterin Levels and Nitric Oxide Synthase Activity

2003 • 289 citations

Pregnane X Receptor Up-Regulation of P-Glycoprotein Expression and Transport Function at the Blood-Brain Barrier

2004 • 287 citations

Microvessel Organization and Structure in Experimental Brain Tumors: Microvessel Populations with Distinctive Structural and Functional Properties

1999 • 278 citations

Neurovascular Protection Reduces Early Brain Injury After Subarachnoid Hemorrhage

2004 • 275 citations

The management of brain edema in brain tumors

2004 • 271 citations

A Comparative Approach

1987 • 270 citations

Na+-dependent Glutamate Transporters (EAAT1, EAAT2, and EAAT3) of the Blood-Brain Barrier

1999 • 269 citations

Induction of various blood-brain barrier properties in non-neural endothelial cells by close apposition to co-cultured astrocytes

1997 • 266 citations

Inflammatory pain alters blood-brain barrier permeability and tight junctional protein expression

2001 • 259 citations

Induction of Astrocyte Differentiation by Endothelial Cells

2001 • 259 citations

Erythropoietin Receptor-mediated Inhibition of Exocytotic Glutamate Release Confers Neuroprotection during Chemical Ischemia

2001 • 253 citations

Aquaporin water channels and endothelial cell function*

2002 • 246 citations

Glial Cell Line-Derived Neurotrophic Factor Induces Barrier Function of Endothelial Cells Forming the Blood–Brain Barrier

1999 • 242 citations

Endothelial Protection by High-Density Lipoproteins

2003 • 235 citations

Induction of blood–brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors

1999 • 223 citations

Choroid plexus: Target for polypeptides and site of their synthesis

2000 • 222 citations

Longchain n−3 polyunsaturated fatty acids and blood vessel function

2001 • 214 citations

Secretion of interleukin‐1β by astrocytes mediates endothelin‐1 and tumour necrosis factor‐α effects on human brain microvascular endothelial cell permeability

2003 • 214 citations

Dietary Flavonoids as Potential Neuroprotectants

2002 • 206 citations

The Blood‐Brain Barrier and Cerebrovascular Pathology in Alzheimer's Disease

1999 • 200 citations

Redistribution of aquaporin-4 in human glioblastoma correlates with loss of agrin immunoreactivity from brain capillary basal laminae

2004 • 193 citations

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

2003 • 190 citations

Astrocyte-mediated control of cerebral microcirculation

2003 • 181 citations

Introduction to the Blood-Brain Barrier

1998 • 180 citations

Angiogenesis of the blood‐brain barrier in vitro and the function of cerebral pericytes

2002 • 177 citations

Agrin and microvascular damage in Alzheimer’s disease

2000 • 169 citations

Prediction of blood–brain barrier permeation in drug discovery from in vivo, in vitro and in silico models

2004 • 169 citations

Blood-brain interfaces in vertebrates: a comparative approach

1984 • 167 citations

Erythropoietin protects the in vitro blood–brain barrier against VEGF‐induced permeability

2003 • 165 citations

Rapid Regulation of P-Glycoprotein at the Blood-Brain Barrier by Endothelin-1

2004 • 162 citations

Mechanisms of glucose transport at the blood–brain barrier: an in vitro study

2001 • 159 citations

VEGF Protects Brain against Focal Ischemia without Increasing Blood–Brain Permeability When Administered Intracerebroventricularly

2005 • 156 citations

Neurobarrier Coupling in the Brain: A Partner of Neurovascular and Neurometabolic Coupling?

2005 • 154 citations

Exposure of tumor necrosis factor‐α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

1995 • 153 citations

A model for the propagation of intercellular calcium waves

1994 • 151 citations

Minireview: Role of Glia in Neuroendocrine Function

2003 • 150 citations

Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood–brain barrier

2004 • 146 citations

Role of Arginine Vasopressin V₁ and V₂ Receptors for Brain Damage After Transient Focal Cerebral Ischemia

2005 • 141 citations

Emerging molecular mechanisms of brain tumour oedema

2001 • 140 citations

Modulation of p-Glycoprotein Transport Function at the Blood-Brain Barrier

2005 • 138 citations

Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy

2001 • 134 citations

Mechanics of resting isolated single vascular smooth muscle cells from bovine coronary artery

1984 • 129 citations

Introduction to the blood-brain barrier : methodology, biology, and pathology

2006 • 128 citations

Where is the blood–brain barrier … really?

2005 • 126 citations

Interferon-Beta Prevents Cytokine-Induced Neutrophil Infiltration and Attenuates Blood–Brain Barrier Disruption

2003 • 122 citations

Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein

1999 • 122 citations

Astrocytes in glutamate neurotransmission

1995 • 121 citations

Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain.

1999 • 115 citations

Bradykinin Induces Interleukin‐6 Expression in Astrocytes Through Activation of Nuclear Factor‐κB

1999 • 114 citations

Functional Expression and Localization of P-glycoprotein in the Central Nervous System: Relevance to the Pathogenesis and Treatment of Neurological Disorders

2004 • 114 citations

Induction of aquaporin 1 but not aquaporin 4 messenger RNA in rat primary brain microvessel endothelial cells in culture

2005 • 111 citations

Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeet

2002 • 110 citations

Blood-brain barrier disruption highly induces aquaporin-4 mRNA and protein in perivascular and parenchymal astrocytes: Protective effect by estradiol treatment in ovariectomized animals

2005 • 109 citations

Drug Resistance in Epilepsy: The Role of the Blood–Brain Barrier

2002 • 105 citations

Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism

2004 • 102 citations

Na⁺-dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier

2003 • 102 citations

Antiatherosclerotic effects of dietary supplementations of garlic and turmeric: Restoration of endothelial function in rats

2005 • 99 citations

Glucose Transporter Asymmetries in the Bovine Blood-Brain Barrier

2001 • 96 citations

Astrocytes enhance radical defence in capillary endothelial cells constituting the blood‐brain barrier

1999 • 94 citations

Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFκB

2003 • 92 citations

Lactate induces tumour necrosis factor‐α, interleukin‐6 and interleukin‐1β release in microglial‐ and astroglial‐enriched primary cultures

2005 • 91 citations

Adrenomedullin regulates blood–brain barrier functions in vitro

2001 • 91 citations

Synergistic effects of neurons and astrocytes on the differentiation of brain capillary endothelial cells in culture

2003 • 88 citations

Transforming Growth Factor-β Mediates Astrocyte-Specific Regulation of Brain Endothelial Anticoagulant Factors

1999 • 87 citations

Soy and Alfalfa Phytoestrogen Extracts Become Potent Low-Density Lipoprotein Antioxidants in the Presence of Acerola Cherry Extract

2000 • 87 citations

The cerebral vasculature as a therapeutic target for neurological disorders and the role of shear stress in vascular homeostatis and pathophysiology

2004 • 85 citations

Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood–brain barrier in vitro

2003 • 82 citations

Vascular and Parenchymal Mechanisms in Multiple Drug Resistance: a Lesson from Human Epilepsy

2003 • 81 citations

The Blood‐Brain Barrier and Its Role in Inflammation

2000 • 81 citations

Astrocyte Growth Stimulation by a Soluble Factor Produced by Cerebral Endothelial Cellsin vitro

1990 • 79 citations

Antioxidants and endothelium protection

2005 • 79 citations

Human blood-derived macrophages enhance barrier function of cultured primary bovine and human brain capillary endothelial cells

2003 • 76 citations

Astrocytes and Ependymal Glia

2004 • 73 citations

Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis‐acting regulatory element

2002 • 72 citations

Gene and protein expression profiling of human cerebral endothelial cells activated with tumor necrosis factor-$alpha;

2003 • 68 citations

5-hydroxytryptamine and glutamate modulate velocity and extent of intercellular calcium signalling in hippocampal astroglial cells in primary cultures

1999 • 65 citations

Calcium signal communication in the central nervous system

2004 • 63 citations

Signalling pathways influencing basal and H₂O₂‐induced P‐glycoprotein expression in endothelial cells derived from the blood–brain barrier

2003 • 62 citations

Anin vitroblood–brain barrier model: Cocultures between endothelial cells and organotypic brain slice cultures

1998 • 61 citations

Endothelial activation, endothelial dysfunction and premature atherosclerosis in systemic autoimmune diseases.

2003 • 60 citations

Metabotropic glutamate receptor activation induces astroglial swelling.

1994 • 59 citations

Transport in the Central Nervous System

1971 • 59 citations

The Complementary Membranes Forming the Blood‐Brain Barrier

2002 • 59 citations

Effects of omega-3 fatty acids on cytokines and adhesion molecules

2004 • 57 citations

The blood brain barrier in HIV infection

2004 • 57 citations

A two-hour window for hypothermic modulation of early events that impact delayed opening of the rat blood-brain barrier after ischemia

2004 • 55 citations

Protection against hypoxia-induced blood-brain barrier disruption: changes in intracellular calcium

2004 • 55 citations

Aging and the endothelium

2003 • 51 citations

Factor(s) released by glucose-deprived astrocytes enhance glucose transporter expression and activity in rat brain endothelial cells

2001 • 50 citations

ATP-Dependent Astrocyte-Endothelial Calcium Signaling Following Mechanical Damage to a Single Astrocyte in Astrocyte-Endothelial Co-Cultures

2000 • 49 citations

Local brain hypothermia for neuroprotection in stroke treatment and aneurysm repair

2005 • 48 citations

The Blood-Brain Barrier, Amino Acids and Peptides

1989 • 47 citations

Glycerophosphoinositol and dexamethasone improve transendothelial electrical resistance in an in vitro study of the blood–brain barrier

2003 • 46 citations

Glutamate-induced swelling of single astroglial cells in primary culture

1994 • 46 citations

Soy Isoflavones Improve Endothelial Function in Spontaneously Hypertensive Rats in an Estrogen-Independent Manner: Role of Nitric-Oxide Synthase, Superoxide, and Cyclooxygenase Metabolites

2005 • 46 citations

Hyperosmotic mannitol induces Src kinase-dependent phosphorylation of β-catenin in cerebral endothelial cells

2005 • 44 citations

α1-Adrenergic Modulation of Metabotropic Glutamate Receptor-induced Calcium Oscillations and Glutamate Release in Astrocytes

2001 • 44 citations

Bcl-2 in endothelial cells is increased by vitamin E and α-lipoic acid supplementation but not exercise training

2005 • 44 citations

Chemotherapeutic dose intensification for treatment of malignant brain tumors: Recent developments and future directions

2002 • 42 citations

Endothelial cells of the blood-brain barrier: a target for glucocorticoids and estrogens?

2004 • 42 citations

Blood–brain barrier methodology and biology

1998 • 39 citations

Modulation of feeding‐related peptide/protein signals by the blood–brain barrier

2004 • 38 citations

Cerebellar susceptibility to experimental autoimmune encephalomyelitis in SJL/J mice: Potential interaction of immunology with vascular anatomy

2002 • 32 citations

Brain Endothelial Cells as Pharmacological Targets in Brain Tumors

2004 • 27 citations

Astrocytic receptors and second messenger systems

2003 • 27 citations

Vascular aspects of neuroprotection

2004 • 27 citations

Role of intracellular calcium in regulation of brain endothelial permeability

1998 • 26 citations

Effects of Chronic Administration of Fruit Extract (Citrus unshiu MARC) on Endothelial Dysfunction in Streptozotocin-Induced Diabetic Rats

2005 • 24 citations

Preparation of glial extracellular matrix: a novel method to analyze glial–endothelial cell interaction

1997 • 23 citations

Mechanisms of Drug Resistance in Epilepsy: Lessons from Oncology

2002 • 22 citations

Biology of the blood–brain glucose transporter

1998 • 21 citations

Does aerobic fitness influence microvascular function in healthy adults at risk of developing Type 2 diabetes?

2005 • 20 citations

Increased ability of peripheral blood lymphocytes to degrade laminin in multiple sclerosis

2004 • 19 citations

Calcium signal communication between glial and vascular brain cells.

2004 • 18 citations

Diet-Induced Protection against Lipopolysaccharide Includes Increased Hepatic NO Production

1999 • 14 citations

PROTECTION OF BLOOD-BRAIN BARRIER BREAKDOWN BY NIFEDIPINE IN ADRENALINE-INDUCED ACUTE HYPERTENSION

2004 • 7 citations