Differential expression of inflammation‐ and apoptosis‐related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis

Motor Neuron Degeneration in Mice that Express a Human Cu,Zn Superoxide Dismutase Mutation

1994 • 3,959 citations

X-linked IAP is a direct inhibitor of cell-death proteases

1997 • 1,961 citations

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

1995 • 1,424 citations

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1996 • 1,261 citations

Evidence of Increased Oxidative Damage in Both Sporadic and Familial Amyotrophic Lateral Sclerosis

1997 • 792 citations

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

2000 • 700 citations

Natural history of amyotrophic lateral sclerosis in a database population Validation of a scoring system and a model for survival prediction

1995 • 683 citations

Increased 3‐nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1997 • 593 citations

Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide

1998 • 568 citations

Epidemiology of mutations in superoxide dismutase in amyotrophic lateal sclerosis

1997 • 517 citations

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide.

1996 • 464 citations

Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS

1998 • 456 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1995 • 450 citations

Activation of Caspase-3 in Single Neurons and Autophagic Granules of Granulovacuolar Degeneration in Alzheimer's Disease

1999 • 420 citations

Reduction of Background Problems in Nonradioactive Northern and Southern Blot Analyses Enables Higher Sensitivity Than 32P-Based Hybridizations

1993 • 407 citations

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions.

1996 • 397 citations

Motor Neuron–Derived Retinoid Signaling Specifies the Subtype Identity of Spinal Motor Neurons

1998 • 383 citations

Protein modification by the lipid peroxidation product 4‐hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

1998 • 382 citations

Amyotrophic lateral sclerosis: Recent insights from genetics and transgenic mice

1995 • 353 citations

Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

2000 • 346 citations

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

2001 • 204 citations

Circulating levels of tumour necrosis factor-α and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis

2000 • 192 citations

Neuronal Apoptosis in Creutzfeldt-Jakob Disease

1999 • 161 citations

Tumor Necrosis Factor α Induces a Metalloprotease-Disintegrin, ADAM8 (CD 156): Implications for Neuron–Glia Interactions during Neurodegeneration

2000 • 132 citations

Regional Heterogeneity in the Response of Astrocytes following Traumatic Brain Injury in the Adult Rat

1996 • 116 citations

XIAP Regulates DNA Damage-induced Apoptosis Downstream of Caspase-9 Cleavage

2000 • 96 citations

Cystatin C, a protease inhibitor, in degenerating rat hippocampal neurons following transient forebrain ischemia

1995 • 93 citations

Changes in apoptosis-related protein (p53, Bax, Bcl-2 and Fos) expression with DNA fragmentation in the central nervous system in rats after closed head injury

2000 • 80 citations

Oxidative Damage to the c‐fos Gene and Reduction of Its Transcription After Focal Cerebral Ischemia

1999 • 63 citations

Neuronal apoptosis in human immunodeficiency virus infection.

2000 • 61 citations

Induction of Thymosin β4 mRNA Following Focal Brain Ischemia

1996 • 56 citations

Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays

2001 • 51 citations

Diagnosis and progression of ALS

1997 • 51 citations

Serial analysis of gene expression in a microglial cell line

1999 • 50 citations

Soluble TNF receptors partially protect injured motoneurons in the postnatal CNS

2000 • 44 citations

Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ

1994 • 34 citations

Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis

1999 • 33 citations

Identification of macrophage populations expressing tumor necrosis factor-α mRNA in acute multiple sclerosis

1998 • 25 citations

Distribution of glutamate and preproenkephalin messenger RNAs following transient focal cerebral ischemia

1999 • 22 citations

Induction of junD mRNA after transient forebrain ischemia in the rat. Effect of hypothermia

1996 • 22 citations

Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062

2001 • 20 citations

Increased expression of the pro‐inflammatory enzyme cyclooxygenase‐2 in amyotrophic lateral sclerosis

2001 • 20 citations

Two Novel Genes, Human neugrin and Mouse m-neugrin, Are Upregulated with Neuronal Differentiation in Neuroblastoma Cells

2000 • 13 citations