The blood-brain barrier in neuroinflammatory diseases.

Adhesion receptors of the immune system

1990 • 6,585 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE

1967 • 2,534 citations

JUNCTIONS BETWEEN INTIMATELY APPOSED CELL MEMBRANES IN THE VERTEBRATE BRAIN

1969 • 2,408 citations

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

1994 • 2,255 citations

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

1989 • 1,744 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Homozygous disruption of the murine MDR2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease

1993 • 1,437 citations

The AIDS Dementia Complex

1988 • 1,387 citations

The AIDS dementia complex: II. Neuropathology

1986 • 1,280 citations

Presidential Address^*

1967 • 1,183 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Electrical resistance across the blood‐brain barrier in anaesthetized rats: a developmental study.

1990 • 736 citations

The influence of cytokines on the integrity of the blood-brain barrier in vitro

1996 • 641 citations

Arachidonic Acid Cascade and Signal Transduction

1990 • 597 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

How Cells Respond to Stress

1993 • 481 citations

Type 1 interleukin‐1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL‐1–induced cellular activation

1995 • 470 citations

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

1991 • 449 citations

Brain injury, edema, and vascular permeability changes induced by oxygen‐derived free radicals

1984 • 387 citations

Immunoregulators in the nervous system

1991 • 380 citations

Recombinant human interleukin-1 induces meningitis and blood-brain barrier injury in the rat. Characterization and comparison with tumor necrosis factor.

1991 • 375 citations

The Induction of Meningeal Inflammation by Components of the Pneumococcal Cell Wall

1985 • 358 citations

How cancer cells evade chemotherapy: sixteenth Richard and Hinda Rosenthal Foundation Award Lecture.

1993 • 357 citations

Oxygen radicals in cerebral ischemia

1992 • 332 citations

The acute inflammatory response to lipopolysaccharide in cns parenchyma differs from that in other body tissues

1992 • 322 citations

Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain.

1996 • 321 citations

Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal membranes: an electron microscopic immunogold study.

1991 • 312 citations

Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema

1988 • 294 citations

AN ELECTRON MICROSCOPIC STUDY OF THE BLOOD-BRAIN BARRIER IN THE RAT, EMPLOYING SILVER NITRATE AS A VITAL STAIN

1955 • 282 citations

Identity of ED2‐positive perivascular cells in rat brain

1989 • 281 citations

Substantial excretion of digoxin via the intestinal mucosa and prevention of long‐term digoxin accumulation in the brain by the mdrla P‐glycoprotein

1996 • 278 citations

Pathogenesis and pathophysiology of bacterial meningitis

1993 • 265 citations

Drug entry into the brain

1979 • 235 citations

BLOOD-BRAIN BARRIER DAMAGE IN ACUTE MULTIPLE SCLEROSIS PLAQUES

1991 • 235 citations

Elevated central nervous system prostaglandins in human immunodeficiency virus—associated dementia

1994 • 226 citations

Cold‐induced brain edema and infarction are reduced in transgenic mice overexpressing CuZn‐Superoxide dismutase

1991 • 207 citations

Prostaglandins, Prostacyclin, and Thromboxanes

1981 • 206 citations

Haemophilus influenzae lipopolysaccharide-induced blood brain barrier permeability during experimental meningitis in the rat.

1988 • 197 citations

Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients

1995 • 196 citations

Recombinant human tumor necrosis factor α constricts pial arterioles and increases blood-brain barrier permeability in newborn piglets

1992 • 192 citations

Transcytotic pathway for blood-borne protein through the blood-brain barrier.

1988 • 188 citations

Senile plaques in cortex of aged normal monkeys

1985 • 186 citations

The blood-brain barrier. Transport across the cerebral endothelium.

1985 • 184 citations

Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage

1993 • 180 citations

Neuronal and microglial involvement in beta-amyloid protein deposition in Alzheimer's disease.

1990 • 175 citations

Upregulation and coexpression of adhesion molecules correlate with relapsing autoimmune demyelination in the central nervous system.

1990 • 173 citations

Die äussere und innere Sekretion des gesunden Organismus im Lichte der "vitalen Färbung"

1909 • 173 citations

Cytokines and neuropathology

1992 • 172 citations

Expression of immunologically relevant endothelial cell activation antigens on isolated central neurvous system microvessels from patients with multiple sclerosis

1994 • 170 citations

Evidence of persistent blood-brain barrier abnormalities in chronic-progressive multiple sclerosis

1995 • 167 citations

Induction of γ-glutamyl transpeptidase in cultured cerebral endothelial cells by a product released by astrocytes

1987 • 164 citations

Blood-Brain Barrier Abnormalities in Longstanding Multiple Sclerosis Lesions. An Immunohistochemical Study

1994 • 162 citations

Induction of Nitric Oxide Synthase in Rat C6 Glioma Cells

1994 • 157 citations

Adhesion molecules on murine brain microvascular endothelial cells: expression and regulation of ICAM-1 and Lgp 55

1992 • 156 citations

Exposure of tumor necrosis factor‐α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

1995 • 153 citations

Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia

1993 • 152 citations

Modulation of blood-brain barrier permeability by tumor necrosis factor and antibody to tumor necrosis factor in the rat.

1992 • 151 citations

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1990 • 149 citations

A morphometric study of the blood-brain barrier in Alzheimer's disease.

1992 • 148 citations

Increased collagen content of cerebral microvessels in Alzheimer's disease

1995 • 146 citations

Blockade of nitric oxide formation by mitigates ischemic brain edema and subsequent cerebral infarction in rats

1992 • 142 citations

Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs.

1988 • 139 citations

Expanding the definition of the blood-brain barrier to protein.

1981 • 135 citations

The blood-brain barrier and cerebral microcirculation in Alzheimer disease.

1992 • 131 citations

Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest

1994 • 130 citations

Interleukin‐1 receptors on rat brain endothelial cells: a role in neuroimmune interaction?

1996 • 129 citations

Elevated vascular cell adhesion molecule-1 in AIDS encephalitis induced by simian immunodeficiency virus.

1992 • 126 citations

Microvasculature in Brain Biopsy Specimens from Patients with Alzheimer's Disease: An Immunohistochemical and Ultrastructural Study

1994 • 125 citations

Prostaglandin Profiles in Tissue and Blood Vessels from Human Brain

1980 • 115 citations

Blood‐Brain Barrier Monoamine Oxidase: Enzyme Characterization in Cerebral Microvessels and Other Tissues from Six Mammalian Species, Including Human

1987 • 115 citations

Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis

1990 • 110 citations

Immunoreactive A4 and gamma-trace peptide colocalization in amyloidotic arteriolar lesions in brains of patients with Alzheimer's disease.

1990 • 109 citations

Accumulation of intercellular adhesion molecule-1 in senile plaques in brain tissue of patients with Alzheimer's disease.

1994 • 104 citations

Selective Degeneration of Oligodendrocytes Mediated by Reactive Oxygen Species

1990 • 104 citations

Oligodendroglial cell death induced by oxygen radicals and its protection by catalase

1991 • 101 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

PATTERNS OF BLOOD-BRAIN BARRIER BREAKDOWN IN INFLAMMATORY DEMYELINATION

1991 • 100 citations

Expression and functional activity of P-glycoprotein in cultured cerebral capillary endothelial cells.

1992 • 99 citations

T Cells in Multiple Sclerosis and Inflammatory Central Nervous System Diseases

1987 • 99 citations

Breakdown of the Blood–Brain Barrier After Fluid Percussion Brain Injury in the Rat: Part 2: Effect of Hypoxia on Permeability to Plasma Proteins

1992 • 95 citations

Eicosanoid metabolism in cerebromicrovascular endothelium

1988 • 94 citations

Effects of interferon-gamma on primary cultures of human brain microvessel endothelial cells.

1993 • 94 citations

Three openings of the blood-brain barrier produced by forebrain ischemia in the rat

1993 • 92 citations

P-glycoprotein and pharmacokinetics.

1995 • 92 citations

Ultrastructural permeability properties of cerebral microvasculature under normal and experimental conditions after application of tracers.

1980 • 90 citations

Action site of circulating interleukin-1 on the rabbit brain

1991 • 89 citations

Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and γ-IFN levels in serum and cerebrospinal fluid

1989 • 88 citations

HIV infection of human brain capillary endothelial cell — Implications for AIDS dementia

1994 • 86 citations

Increased vesicular transport and decreased mitochondrial content in blood-brain barrier endothelial cells during experimental autoimmune encephalomyelitis.

1989 • 85 citations

Evidence of Serum-Protein Leakage Across the Blood-Brain Barrier in the Acquired Immunodeficiency Syndrome

1991 • 82 citations

STUDY ON THE POSSIBLE ENTRY OF BACTERIAL ENDOTOXIN AND PROSTAGLANDIN E₂ INTO THE CENTRAL NERVOUS SYSTEM FROM THE BLOOD

1979 • 81 citations

Comparisons of P‐glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta

1995 • 80 citations

The role of the blood-brain barrier in HIV infection of the central nervous system

1994 • 79 citations

Catecholamine‐Metabolizing Enzymes of Bovine Brain Microvessel Endothelial Cell Monolayers

1986 • 74 citations

Adhesion molecules on endothelial cells in the central nervous system: An emerging area in the neuroimmunology of multiple sclerosis

1990 • 73 citations

Blood-brain-barrier in a geriatric population: barrier function in degenerative and vascular dementias

1991 • 72 citations

The pathogenesis of multiple sclerosis

1993 • 71 citations

Soluble ICAM‐1 serum levels in multiple sclerosis and viral encephalitis

1993 • 70 citations

Eicosanoid production by rat cerebral endothelial cells: Stimulation by lipopolysaccharide, interleukin-1 and interleukin-6

1995 • 70 citations

BLOOD-BRAIN BARRIER TRANSPORT OF NUTRIENTS

2009 • 68 citations

Altered blood-brain-barrier function in Alzheimer's disease?

2009 • 66 citations

Oxygen Free Radicals in the Genesis of Traumatic and Peritumoral Brain Edema

1989 • 66 citations

Breaching the Blood-Brain Barrier

1993 • 55 citations

Lymphocyte adhesion to brain capillary endothelial cells in vitro

1994 • 53 citations

Role of cerebral endothelium in brain oedema

1989 • 53 citations

Enhancement of ATPase Activity by a Lipid Peroxide of Arachidonic Acid in Rat Brain Microvessels

1986 • 47 citations

The blood-brain barrier and multiple sclerosis

1994 • 46 citations

A Spatial Analysis of the Blood—Brain Barrier Damage in Experimental Allergic Encephalomyelitis

1985 • 46 citations

Changes in the glucose transporter of brain capillaries

1992 • 43 citations

Nitric oxide modulates blood-brain barrier permeability during infections with an inactivated bacterium

1995 • 40 citations

The immunology of sepsis and meningitis--cytokine biology.

1990 • 40 citations

Metabolic basis of brain edema.

1980 • 38 citations

Molecular and cellular biology of Alzheimer amyloid

1992 • 36 citations

Lymphocyte migration into the CNS modelled in vitro

1992 • 35 citations

Drug Transport in the Central Nervous System: Role of Carriers

1990 • 33 citations

Blood-brain barrier (BBB). Review from morphological aspect.

1988 • 33 citations

Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex

1992 • 29 citations

The effect of 5-lipoxygenase inhibition on blood-brain barrier permeability in experimental brain tumors

1992 • 29 citations

Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission

1995 • 27 citations

Pathophysiological aspects of acute experimental allergic encephalomyelitis

1988 • 26 citations

In vivo relationship of interleukin-2 and soluble IL-2 receptor to blood-brain barrier impairment in patients with active multiple sclerosis

1993 • 26 citations

Cerebral microvessels in Alzheimer's have reduced protein kinase C activity

1995 • 26 citations

Relation between the increase in the diffusional permeability of the blood-central nervous system barrier and other changes during the development of experimental allergic encephalomyelitis in the lewis rat

1983 • 24 citations

Absence of Immorally mediated damage within the central nervous system of AIDS patients

1989 • 22 citations

Concordance and localization of maximal vascular permeability change and fibrin deposition in the central neuraxis of Lewis rats with cell-transferred experimental allergic encephalomyelitis

1992 • 20 citations

Blood-brain transport of nutrients. Introduction.

1986 • 20 citations

Correlations between morphological changes in platelet aggregates and underlying endothelial damage in cerebral microcirculation of mice.

1993 • 20 citations

Localisation of the multidrug resistance-associated protein, MRP, in resistant large-cell lung tumour cells

1995 • 18 citations

Superoxide Dismutase Inhibits Brain Oedema Formation in Experimental Pneumococcal Meningitis

1990 • 14 citations

Nitric Oxide Synthase Localization in Cultured Cerebrovascular Endothelium during Mitosis

1994 • 13 citations

Amyloid β-protein precursor and apolipoprotein E production in cultured cerebral endothelial cells isolated from brains of patients with neurodegenerative disorders at autopsy

1995 • 11 citations

Chapter 57: Aspects of normal cerebrospinal fluid circulation and circumventricular organs

1992 • 6 citations

HIV infection and the brain

1991 • 4 citations

The Role of Endothelial Second Messenger’s-Generating System in the Pathogenesis of Brain Oedema

1990 • 1 citations