Junctional complexes of the blood–brain barrier: permeability changes in neuroinflammation

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Angiogenesis.

1992 • 2,581 citations

In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse

1999 • 2,410 citations

Multifunctional strands in tight junctions

2001 • 2,392 citations

Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia.

1986 • 1,588 citations

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

1998 • 1,356 citations

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

1998 • 1,331 citations

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

1999 • 1,100 citations

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

1999 • 1,094 citations

Metalloproteinases in biology and pathology of the nervous system

2001 • 1,032 citations

THE CELL BIOLOGY OF THE BLOOD-BRAIN BARRIER

1999 • 988 citations

Effects of Matrix Metalloproteinase-9 Gene Knock-Out on the Proteolysis of Blood–Brain Barrier and White Matter Components after Cerebral Ischemia

2001 • 982 citations

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

1994 • 949 citations

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 • 847 citations

TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors

2001 • 773 citations

Inflammatory mediators and modulation of blood-brain barrier permeability.

2000 • 769 citations

Molecular physiology and pathophysiology of tight junctions in the blood–brain barrier

2001 • 742 citations

MOLECULAR ARCHITECTURE OF TIGHT JUNCTIONS

1998 • 718 citations

ZO-3, a Novel Member of the MAGUK Protein Family Found at the Tight Junction, Interacts with ZO-1 and Occludin

1998 • 592 citations

New concepts in the immunopathogenesis of multiple sclerosis

2002 • 582 citations

Possible Involvement of Phosphorylation of Occludin in Tight Junction Formation

1997 • 576 citations

Outwitting the Blood-Brain Barrier for Therapeutic Purposes: Osmotic Opening and Other Means

1998 • 574 citations

The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha-catenin with vascular endothelial cadherin (VE-cadherin).

1995 • 573 citations

Stimulation of endothelial cell migration by vascular permeability factor/vascular endothelial growth factor through cooperative mechanisms involving the alphavbeta3 integrin, osteopontin, and thrombin.

1996 • 555 citations

The role of magnetic resonance techniques in understanding and managing multiple sclerosis

1998 • 553 citations

Structure, biochemistry, and assembly of epithelial tight junctions

1987 • 532 citations

An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3

1998 • 508 citations

The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions.

1993 • 467 citations

The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

1986 • 446 citations

Transmembrane control of cadherin-mediated cell adhesion: a 94 kDa protein functionally associated with a specific region of the cytoplasmic domain of E-cadherin.

1989 • 436 citations

Drug and gene targeting to the brain with molecular trojan horses

2002 • 430 citations

Transporting therapeutics across the blood-brain barrier

1996 • 429 citations

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.

1994 • 428 citations

In VivoDelivery of a Bcl-xL Fusion Protein Containing the TAT Protein Transduction Domain Protects against Ischemic Brain Injury and Neuronal Apoptosis

2002 • 418 citations

Neutrophils Emigrate from Venules by a Transendothelial Cell Pathway in Response to FMLP

1998 • 415 citations

Matrix Metalloproteinase Inhibition Prevents Oxidative Stress-Associated Blood–Brain Barrier Disruption after Transient Focal Cerebral Ischemia

2001 • 382 citations

Cerebral microvascular changes in permeability and tight junctions induced by hypoxia-reoxygenation

2002 • 375 citations

Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis.

1996 • 372 citations

Selective expression of adhesion molecules on human brain microvascular endothelial cells

1997 • 368 citations

Loss of the tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood–brain barrier breakdown in vivo

1998 • 354 citations

Reduction of inflammation, tissue damage, and mortality in bacterial meningitis in rabbits treated with monoclonal antibodies against adhesion-promoting receptors of leukocytes.

1989 • 339 citations

Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions.

1996 • 334 citations

Fighting Cancer by Attacking its Blood Supply

1996 • 331 citations

Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues.

1996 • 329 citations

Drug Delivery to the Brain

1997 • 313 citations

Extracellular proteolysis in brain injury and inflammation: Role for plasminogen activators and matrix metalloproteinases

2002 • 313 citations

Lymphocyte Migration Through Brain Endothelial Cell Monolayers Involves Signaling Through Endothelial ICAM-1 Via a Rho-Dependent Pathway

1999 • 299 citations

ICAM-1-Coupled Cytoskeletal Rearrangements and Transendothelial Lymphocyte Migration Involve Intracellular Calcium Signaling in Brain Endothelial Cell Lines

2000 • 296 citations

Mediators of Blood-Brain Barrier Dysfunction and Formation of Vasogenic Brain Edema

1988 • 294 citations

Cingulin Contains Globular and Coiled-Coil Domains and Interacts with Zo-1, Zo-2, Zo-3, and Myosin

1999 • 294 citations

Rho: theme and variations

1996 • 290 citations

Leukocyte Recruitment in the Cerebrospinal Fluid of Mice with Experimental Meningitis Is Inhibited by an Antibody to Junctional Adhesion Molecule (Jam)

1999 • 288 citations

Cadherins and their connections: adhesion junctions have broader functions

1999 • 288 citations

Assembly and sealing of tight junctions: Possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin

1991 • 280 citations

Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners.

1997 • 280 citations

Effect of steroids on CSF matrix metalloproteinases in multiple sclerosis

1996 • 278 citations

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

2001 • 274 citations

Regulated assembly of tight junctions by protein kinase C.

1995 • 262 citations

Matrix Metalloproteinases Contribute to Brain Damage in Experimental Pneumococcal Meningitis

2000 • 259 citations

Resistance of young gelatinase B–deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions

1999 • 259 citations

THE TIGHT JUNCTION: Morphology to Molecules

1998 • 255 citations

Matrix Metalloproteinase (MMP)-8 and MMP-9 in Cerebrospinal Fluid during Bacterial Meningitis: Association with Blood-Brain Barrier Damage and Neurological Sequelae

2000 • 252 citations

ICAM-1 Signaling Pathways Associated with Rho Activation in Microvascular Brain Endothelial Cells

1998 • 252 citations

Abnormal Endothelial Tight Junctions in Active Lesions and Normal‐appearing White Matter in Multiple Sclerosis

2002 • 251 citations

Cell signalling: MAGUK magic

1996 • 248 citations

Glial Cell Line-Derived Neurotrophic Factor Induces Barrier Function of Endothelial Cells Forming the Blood–Brain Barrier

1999 • 242 citations

Intercellular adhesion molecule 1 activation induces tyrosine phosphorylation of the cytoskeleton-associated protein cortactin in brain microvessel endothelial cells.

1994 • 241 citations

Vascular Endothelial Junction-associated Molecule, a Novel Member of the Immunoglobulin Superfamily, Is Localized to Intercellular Boundaries of Endothelial Cells

2000 • 239 citations

Histamine Induces Tyrosine Phosphorylation of Endothelial Cell-to-Cell Adherens Junctions

1999 • 229 citations

p120ctn Acts as an Inhibitory Regulator of Cadherin Function in Colon Carcinoma Cells

1999 • 229 citations

Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis

2001 • 225 citations

Endothelial cell tube formation depends on cadherin 5 and CD31 interactions with filamentous actin.

1997 • 209 citations

Purification of a 92-kDa cytoplasmic protein tightly associated with the cell-cell adhesion molecule E-cadherin (uvomorulin)

1991 • 208 citations

Multiple domains of occludin are involved in the regulation of paracellular permeability

2000 • 201 citations

Physiology and Pharmacology of the Blood-Brain Barrier

1992 • 199 citations

Serum gelatinase B, TIMP-1 and TIMP-2 levels in multiple sclerosis

1999 • 199 citations

Protein trafficking and polarity in kidney epithelium: from cell biology to physiology

1996 • 196 citations

Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins

1999 • 196 citations

PATHOGENESIS OF BACTERIAL MENINGITIS

1999 • 192 citations

Analysis of tight junctions during neutrophil transendothelial migration

2000 • 191 citations

Dexamethasone regulation of matrix metalloproteinase expression in CNS vascular endothelium

2000 • 190 citations

Endothelial-dependent Mechanisms Regulate Leukocyte Transmigration: A Process Involving the Proteasome and Disruption of the Vascular Endothelial–Cadherin Complex at Endothelial Cell-to-Cell Junctions

1997 • 182 citations

Increased levels of circulating ICAM-1 in serum and cerebrospinal fluid of patients with active multiple sclerosis. Correlation with TNF-α and blood-brain barrier damage

1993 • 180 citations

Lysophosphatidic Acid Increases Tight Junction Permeability in Cultured Brain Endothelial Cells

1997 • 172 citations

Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Barrier Drug Targeting System

2001 • 172 citations

Occludin proteolysis and increased permeability in endothelial cells through tyrosine phosphatase inhibition

1999 • 171 citations

Matrix metalloproteinase-9 and -7 are regulated in experimental autoimmune encephalomyelitis

1998 • 166 citations

Rapid Disruption of an Astrocyte Interaction With the Extracellular Matrix Mediated by Integrin α₆β₄During Focal Cerebral Ischemia/Reperfusion

1997 • 165 citations

The blood-brain barrier and the inflammatory response

1997 • 157 citations

Controversies at the cytoplasmic face of the cadherin-based adhesion complex

1999 • 156 citations

Effects of Bradykinin on Permeability and Diameter of Pial Vessels In vivo

1984 • 152 citations

Circulating adhesion molecules and tumor necrosis factor receptor in multiple sclerosis: Correlation with magnetic resonance imaging

1995 • 150 citations

Immunohistochemical localization of adherens junction components in blood-brain barrier microvessels of the rat

1993 • 149 citations

Interleukin 6 production in the central nervous system during experimental autoimmune encephalomyelitis

1990 • 149 citations

Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins.

1996 • 143 citations

E-Selectin Appears in Nonischemic Tissue During Experimental Focal Cerebral Ischemia

1996 • 139 citations

Combination of hypoxia/aglycemia compromises in vitro blood-brain barrier integrity.

1999 • 138 citations

Involvement of a Heterotrimeric G Protein α Subunit in Tight Junction Biogenesis

1996 • 136 citations

Changes of serum sICAM-1 and MMP-9 induced by rIFNβ-1b treatment in relapsing-remitting MS

1999 • 127 citations

Identification of Isoforms of G Proteins and PKC that Colocalize with Tight Junctions

1996 • 127 citations

Role of cadherins in the transendothelial migration of melanoma cells in culture

1997 • 122 citations

Protein kinase C-ζ mediates TNF-α-induced ICAM-1 gene transcription in endothelial cells

2000 • 118 citations

Vascular endothelial growth factor affects permeability of brain microvessel endothelial cells in vitro

1996 • 117 citations

Circulating adhesion molecules and inflammatory mediators in demyelination

1995 • 113 citations

Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis

1990 • 110 citations

Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid

1998 • 109 citations

Localization of 7H6 Tight Junction-Associated Antigen along the Cell Border of Vascular Endothelial Cells Correlates with Paracellular Barrier Function against Ions, Large Molecules, and Cancer Cells

1996 • 104 citations

Identification, Characterization, and Precise Mapping of a Human Gene Encoding a Novel Membrane-Spanning Protein from the 22q11 Region Deleted in Velo–Cardio–Facial Syndrome

1997 • 103 citations

In Vitro Degradation of Endothelial Catenins by a Neutrophil Protease

1998 • 102 citations

The SH3 domain of the tight junction protein ZO‐1 binds to a serine protein kinase that phosphorylates a region C‐terminal to this domain

1996 • 102 citations

The Development of the Bradykinin Agonist Labradimil as a Means to Increase the Permeability of the Blood-Brain Barrier

2001 • 101 citations

Tight junctions and their role in cancer metastasis.

2001 • 99 citations

Enhanced attenuation of meningeal inflammation and brain edema by concomitant administration of anti-CD18 monoclonal antibodies and dexamethasone in experimental Haemophilus meningitis.

1991 • 99 citations

Histamine stimulates phosphorylation of adherens junction proteins and alters their link to vimentin

2002 • 98 citations

Mechanisms of α-thrombin, histamine, and bradykinin induced endothelial permeability

1996 • 88 citations

Cloning of JAM-2 and JAM-3: an Emerging Junctional Adhesion Molecular Family

2000 • 80 citations

Cross-regulation of the Wnt signalling pathway: a role of MAP kinases

2000 • 78 citations

Effect of inflammatory agents on electrical resistance across the blood-brain barrier in pial microvessels of anaesthetized rats

1995 • 77 citations

Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells

2000 • 74 citations

Astroglial cells inhibit the increasing permeability of brain endothelial cell monolayer following hypoxia/reoxygenation

1996 • 70 citations

Receptor-mediated changes in intracellular [Ca2+] in cultured rat brain capillary endothelial cells

1991 • 67 citations

Lymphocyte migration into the CNS modelled in vitro: roles of LFA-1, ICAM-1 and VLA-4.

1994 • 65 citations

Vascular Endothelial Growth Factor in Bacterial Meningitis: Detection in Cerebrospinal Fluid and Localization in Postmortem Brain

2001 • 57 citations

Expression of vascular endothelial growth factor in tuberculous meningitis

2001 • 47 citations

Regulation of cerebral microvascular permeability by histamine in the anaesthetized rat

1998 • 47 citations

Endothelial Adherens Junctions

2000 • 46 citations

Ultrastructure of Brain Endothelium

1992 • 46 citations

Drug delivery to the nervous system

1997 • 45 citations

Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells

2000 • 44 citations

Regulation of the MDCK Cell Tight Junction

1998 • 41 citations

Vascular cell adhesion molecule-1 mRNA is expressed in immune-mediated and ischemic injury of the rat nervous system

1996 • 40 citations

Infiltration of inflammatory cells through brain endothelium.

1998 • 40 citations

The non-receptor tyrosine kinase Lyn is localised in the developing murine blood-brain barrier

1995 • 35 citations

Neurovascular permeability and fibrin deposition in the central neuraxis of Lewis rats with cell-transferred experimental allergic encephalomyelitis in relationship to clinical and histopathological features of the disease

1993 • 32 citations

Measurement of immune markers in the serum and cerebrospinal fluid of multiple sclerosis patients during clinical remission

1995 • 27 citations

Phosphorylation and disorganization of vascular-endothelial cadherin in interaction between breast cancer and vascular endothelial cells.

1999 • 20 citations

Concordance and localization of maximal vascular permeability change and fibrin deposition in the central neuraxis of Lewis rats with cell-transferred experimental allergic encephalomyelitis

1992 • 20 citations

Kinetics and Polarization of the Membrane Expression of Cytokine-induced ICAM-1 on Rat Brain Endothelial Cells

2000 • 19 citations

Vascular endothelial growth factor stimulates dephosphorylation of the catenins p120 and p100 in endothelial cells

2000 • 17 citations

Transmigration of Leukocytes

2001 • 14 citations