Biochemistry and Molecular Biology of Fibroblast Growth Factors

Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells

1989 • 2,267 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Growth factors in bone matrix. Isolation of multiple types by affinity chromatography on heparin-Sepharose.

1986 • 870 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture.

1986 • 696 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors.

1990 • 635 citations

Isolation of brain fibroblast growth factor by heparin-Sepharose affinity chromatography: identity with pituitary fibroblast growth factor.

1984 • 624 citations

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

1986 • 604 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Regulation of skeletal muscle satellite cell proliferation and differentiation by transforming growth factor‐beta, insulin‐like growth factor I, and fibroblast growth factor

1989 • 541 citations

Distribution of basic fibroblast growth factor in the 18-day rat fetus: localization in the basement membranes of diverse tissues.

1990 • 533 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity.

1988 • 458 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

1987 • 422 citations

Growth factors are released by mechanically wounded endothelial cells.

1989 • 420 citations

Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells invitro: Implications for a role of heparinase-like enzymes in the neovascular response

1987 • 416 citations

Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors

1991 • 386 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Increased basic fibroblast growth factor (bFGF) immunoreactivity at the site of focal brain wounds

1988 • 382 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

Purification of a factor from human placenta that stimulates capillary endothelial cell protease production, DNA synthesis, and migration.

1986 • 354 citations

Diverse forms of a receptor for acidic and basic fibroblast growth factors.

1990 • 352 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Brain basic fibroblast growth factor stimulates the proliferation of rat neuronal precursor cells in vitro

1987 • 336 citations

Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies

1985 • 335 citations

Nuclear and cytoplasmic localization of different basic fibroblast growth factor species

1990 • 332 citations

Translocation of bFGF to the nucleus is G1 phase cell cycle specific in bovine aortic endothelial cells.

1990 • 324 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan

1989 • 304 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.

1985 • 294 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

Subcellular fate of the lnt-2 oncoprotein is determined by choice of initiation codon

1990 • 293 citations

Human endothelial cells are chemotactic to endothelial cell growth factor and heparin.

1985 • 282 citations

Basic fibroblast growth factor stimulates endothelial regrowth and proliferation in denuded arteries.

1990 • 282 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor.

1990 • 274 citations

Fibroblast growth factors

1987 • 273 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos

1989 • 264 citations

Growth factors rapidly induce expression of the glucose transporter gene.

1988 • 263 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

K-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genes.

1990 • 260 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus.

1986 • 234 citations

Isolation and partial molecular characterization of pituitary fibroblast growth factor.

1984 • 225 citations

Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor.

1985 • 221 citations

The biological effects of XTC-MIF: quantitative comparison with Xenopus bFGF

1990 • 220 citations

Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

1989 • 210 citations

Pituitary follicular cells produce basic fibroblast growth factor.

1987 • 200 citations

Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture.

1988 • 197 citations

A murine fibroblast growth factor (FGF) receptor expressed in CHO cells is activated by basic FGF and Kaposi FGF.

1990 • 196 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries.

1988 • 193 citations

Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors.

1990 • 187 citations

Acidic fibroblast growth factor enhances regeneration of processes by postnatal mammalian retinal ganglion cells in culture.

1988 • 181 citations

Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

1985 • 180 citations

Sulfated proteoglycan synthesis by confluent cultures of rabbit costal chondrocytes grown in the presence of fibroblast growth factor.

1985 • 179 citations

Characterization and Chromosome Assignment of the Human Homolog of int-2, a Potential Proto-Oncogene

1986 • 178 citations

Growth of normal human keratinocytes and fibroblasts in serum‐free medium is stimulated by acidic and basic fibroblast growth factor

1989 • 174 citations

Identification of a developmentally regulated protein-tyrosine kinase by using anti-phosphotyrosine antibodies to screen a cDNA expression library.

1989 • 165 citations

Complete primary structure of prostatropin, a prostate epithelial cell growth factor

1986 • 163 citations

Mitogenic Growth Factors and Nerve Dependence of Limb Regeneration

1984 • 154 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

α2-macroglobulin is a binding protein for basic fibroblast growth factor

1989 • 152 citations

Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

1986 • 151 citations

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

1988 • 150 citations

Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene.

1986 • 149 citations

Heparin protects heparin-binding growth factor-I from proteolytic inactivation in vitro

1988 • 149 citations

Isolation of Fibroblast Growth Factor from Bovine Adrenal Gland: Physicochemical and Biological Characterization*

1986 • 145 citations

RETRACTED: Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo.

1989 • 142 citations

Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix.

1989 • 141 citations

Regulation of the fibroblast growth factor receptor in early Xenopus embryos.

1990 • 135 citations

The mitogenic signaling pathway but not the plasminogen activator-inducing pathway of basic fibroblast growth factor is mediated through protein kinase C in fetal bovine aortic endothelial cells.

1989 • 133 citations

Fibroblast Growth Factor Receptor Is a Portal of Cellular Entry for Herpes Simplex Virus Type 1

1990 • 133 citations

Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes

1989 • 133 citations

A distinctive family of embryonic protein-tyrosine kinase receptors.

1990 • 132 citations

Related fibroblast growth factor receptor genes exist in the human genome.

1990 • 131 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Purification of cartilage-derived growth factor by heparin affinity chromatography.

1985 • 129 citations

Isolation of pituitary fibroblast growth factor by fast protein liquid chromatography (FPLC): Partial chemical and biological characterization

1985 • 128 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Human brain-derived acidic and basic fibroblast growth factors: Amino terminal sequences and specific mitogenic activities

1986 • 112 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

Growth of human corneal endothelial cells in culture.

1989 • 111 citations

Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.

1988 • 107 citations

Fibroblast growth factor in the human placenta

1985 • 107 citations

The murine flg gene encodes a receptor for fibroblast growth factor.

1990 • 106 citations

Growth Stimulation of Rat Calvaria Osteoblastic Cells by Acidic Fibroblast Growth Factor

1987 • 106 citations

Conversion of cysteine to serine residues alters the activity, stability, and heparin dependence of acidic fibroblast growth factor.

1991 • 105 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

Effects of acidic and basic fibroblast growth factors (aFGF and bFGF) on the proliferation and the glutamine synthetase expression of rat astroblasts in culture

1988 • 104 citations

Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.

1988 • 98 citations

Analysis of competence: receptors for fibroblast growth factor in early Xenopus embryos

1989 • 97 citations

Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate.

1986 • 96 citations

Early release of glia maturation factor and acidic fibroblast growth factor after rat brain injury

1988 • 94 citations

Expression of the K-fgf proto-oncogene is controlled by 3' regulatory elements which are specific for embryonal carcinoma cells.

1990 • 93 citations

Isolation and partial characterization of basic fibroblast growth factor from bovine testis

1987 • 93 citations

Differential phenotypic expression induced in cultured rat astroblasts by acidic fibroblast growth factor, epidermal growth factor, and thrombin

1989 • 87 citations

Effect of heparin on the stimulation of non-vascular cells by human acidic and basic FGF

1986 • 83 citations

Stabilization by heparin of acidic fibroblast growth factor mitogenicity for human endothelial cells in vitro

1989 • 79 citations

An antisense transcript from the Xenopus laevis bFGF gene coding for an evolutionarily conserved 24 kd protein.

1989 • 79 citations

The genes for basic and acidic fibroblast growth factors are on different human chromosomes

1986 • 78 citations

Enhancement of angiogenesis by bFGF in mandibular bone graft healing in the rabbit

1988 • 78 citations

Fibroblast growth factor phosphorylation and receptors in rod outer segments.

1989 • 76 citations

Isolation of heparin‐binding growth factors from bovine, porcine and canine hearts

1989 • 72 citations

Heparin-binding Growth Factors Stimulate DNA Synthesis in Rat Alveolar Type II Cells

1990 • 70 citations

Acidic fibroblast growth factor is present in nonneural tissue: isolation and chemical characterization from bovine kidney

1987 • 69 citations

Structure, chromosome mapping and expression of the murine Fgf-6 gene.

1990 • 67 citations

Disulfide Bonds are Neither Required, Present, Nor Compatible with Full Activity of Human Recombinant Acidic Fibroblast Growth Factor

1990 • 66 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture.

1989 • 65 citations

Regulation of eye derived growth factor binding to membranes by light, ATP or GTP in photoreceptor outer segments.

1988 • 63 citations

Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells.

1989 • 59 citations

Fibroblast growth factors are present in adult cardiac myocytes, Invivo

1988 • 56 citations

Expression of the HST1 oncogene in human germ cell tumors

1988 • 55 citations

Differential effects of heparin, fibronectin, and laminin on the phosphorylation of basic fibroblast growth factor by protein kinase C and the catalytic subunit of protein kinase A.

1989 • 55 citations

Stimulation in cell culture of mesenchymal cells of newt limb blastemas by EDGF I or II (basic or acidic FGF)

1987 • 53 citations

Purification of Acidic Fibroblast Growth Factor from Bovine Heart and Its Localization in the Cardiac Myocytes

1989 • 51 citations

Purification of 18- and 22-kDa Forms of Basic Fibroblast Growth Factor from Rat Cells Transformed by the ras Oncogene

1989 • 51 citations

Alternative splicing generates two forms of mRNA coding for human heparin-binding growth factor 1.

1990 • 50 citations

Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin

1989 • 48 citations

Mediation of virion penetration into vascular cells by association of basic fibroblast growth factor with herpes simplex virus type 1

1990 • 48 citations

Fibroblast growth factor stimulates protein kinase C in quiescent 3T3 cells without Ca²⁺ mobilization or inositol phosphate accumulation

1990 • 48 citations

Purification and partial characterization of bovine pituitary fibroblast growth factor

1983 • 45 citations

Elevation of acidic fibroblast growth factor mRNA in lesioned rat brain

1988 • 43 citations

Localization of acidic fibroblast growth factor (aFGF) mRNA in mouse and bovine retina by in situ hybridization

1990 • 43 citations

Brain-derived growth factor is a chemoattractant for fibroblasts and astroglial cells

1986 • 41 citations

Internalization and degradation of heparin binding growth factor-I by endothelial cells

1988 • 38 citations

An amino-terminally extended and post-translationally modified form of a 25kD basic fibroblast growth factor

1989 • 38 citations

Characterization of a cysteine-free analog of recombinant human basic fibroblast growth factor

1989 • 38 citations

Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors

1989 • 35 citations

Molecular biology of cancer genes

1991 • 34 citations

The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA

1990 • 33 citations

Purification and characterization of heparin-binding growth factors from porcine uterus

1990 • 33 citations

Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

1989 • 33 citations

Two homologous oncogenes, HST1 and INT2, are closely located in human genome

1988 • 32 citations

Regulation of neuroblast proliferation by hormones and growth factors in chemically defined medium

1988 • 32 citations

Purification of acidic fibroblast growth factor from bovine omentum

1989 • 25 citations

Fibroblast growth factor‐dependent mitogenic signal transduction pathway in chemically transformed mouse fibroblasts is similar to but distinct from that initiated by phorbol esters

1990 • 25 citations

Chromosome assignment by polymerase chain reaction techniques: assignment of the oncogene FGF-5 to human chromosome 4.

1990 • 24 citations

Effects of acidic and basic fibroblast growth factors on the proliferation of rabbit corneal cells

1990 • 23 citations

Structural analysis of the gene for human acidic fibroblast growth factor

1989 • 21 citations

Detection of acidic fibroblast growth factor mRNA in the rat ovary using reverse transcription-polymerase chain reaction amplification

1989 • 21 citations

Activation of S6 kinase in astroglial cells by FGFa and FGFb

1989 • 20 citations

The gene for human acidic fibroblast growth factor encodes two upstream exons alternatively spliced to the first coding exon

1990 • 20 citations

Purification and partial characterization of a mitogenic factor from bovine liver: structural homology with basic fibroblast growth factor

1986 • 19 citations

Effect of heparin on the angiogenic potency of basic and acidic fibroblast growth factors in the rabbit cornea assay.

1988 • 18 citations

Multiple polyadenylation sites downstream from the human aFGF gene encoding acidic fibroblast growth factor

1989 • 15 citations

Rapid appearance of novel phosphoproteins in the nuclei of mitogen-stimulated fibroblasts.

1988 • 12 citations

Isolation of heparin‐binding growth factors from dogfish (Mustela canis) brain and retina

1986 • 12 citations

Effect of heparin-binding growth factors on monovalent cation transport in Balb/C 3T3 cells

1987 • 9 citations

Enhancement of wound closure and breaking strength in rodents with acidic fibroblast growth factor

1988 • 1 citations